TY  - JOUR
VL  - 26
ID  - publicatio16336
TI  - Cardiac Amyloidosis Associated with Enlargement and Functional Impairment of the Mitral Annulus: Insights from the Three-Dimensional Speckle Tracking Echocardiographic MAGYAR-Path Study
IS  - 3
Y1  - 2017///
JF  - JOURNAL OF HEART VALVE DISEASE
A1  -  Nemes Attila
A1  -  Földeák Dóra Melinda
A1  -  Kormányos Árpád
A1  -  Domsik Péter
A1  -  Kalapos Anita
A1  -  Borbényi Zita
A1  -  Forster Tamás
N2  - BACKGROUND: Cardiac amyloidosis (CA) is a rare condition characterized by the extracellular deposition of amyloidogenic proteins in the heart. The aim of the present study was to compare the size and function of the mitral annulus (MA) between CA patients and age- and gender-matched controls, using three-dimensional speckle-tracking echocardiography (3-D STE). METHODS: The study included 17 patients (mean age 64.2 +/- 9.8 years) with CA, whose results were compared to 26 age- and gender-matched healthy controls (mean age 59.0 +/- 8.2 years). Complete two-dimensional (2-D) Doppler echocardiography and 3-D STE were performed in all cases. RESULTS: Significantly enlarged end-diastolic and end-systolic MA diameters (3.09 +/- 0.56 cm versus 2.70 +/- 0.37 cm, p = 0.01 and 2.71 +/- 0.68 cm versus 1.87 +/- 0.31 cm, p <0.001) and MA area (11.22 +/- 3.56 cm2 versus 8.60 +/- 1.92 cm2, p = 0.004 and 8.57 +/- 3.35 cm2 versus 4.55 +/- 1.05 cm2, p <0.001) were demonstrated in CA. MA fractional area change (24.10 +/- 13.97% versus 46.06 +/- 14.37%, p <0.001) and MA fractional shortening (12.92 +/- 9.55% versus 30.98 +/- 11.65%, p <0.001) were also impaired in CA patients as compared to matched controls. CONCLUSIONS: CA is associated with MA enlargement and functional impairment represented by MA fractional shortening and MA fractional area change, as assessed using 3-D STE.
SP  - 304
AV  - restricted
EP  - 308
SN  - 0966-8519
UR  - http://publicatio.bibl.u-szeged.hu/16336/
ER  -