TY  - JOUR
EP  - 15 p
VL  - 24
A1  -  Danciu Corina
A1  -  Muntean Delia
A1  -  Alexa Ersilia
A1  -  Farcas Claudia
A1  -  Oprean Camelia
A1  -  Zupkó István
A1  -  Bor Andrea
A1  -  Minda Daliana
A1  -  Proks Maria
A1  -  Buda Valentina
A1  -  Hancianu Monica
A1  -  Cioanca Oana
A1  -  Soica Codruta
A1  -  Popescu Sofia
A1  -  Dehelean Cristina Adriana
IS  - 1
SN  - 1420-3049
N2  - Ephedra alata Decne. belongs to the Ephedraceae family. It is a species of Ephedra that grows mostly in the desert. Today, the main importance of Ephedra species in the medical field is due to the presence of the alkaloids derived from phenyl-alanine, which act on the sympathetic nervous system as a sympathomimetic. The aim of this study was to conduct a phytochemical characterization of the hydroalcoholic extract of the aerial part of Ephedra alata Decne., which is indigenous to Tunis, that involves the total phenolic content, individual phenolic content, and antioxidant activity as well as a biological screening for the evaluation of the antimicrobial, antifungal, antiproliferative, pro-apoptotic, and cytotoxic potential against the MCF-7 breast cancer cell line. The results show that the hydroalcoholic extract contains polyphenolic phytocompounds (156.226 +/- 0.5 mgGAE/g extract) and elicits antioxidant activity (7453.18 +/- 2.5 mol Trolox/g extract). The extract acted as a bacteriostatic agent against all tested bacterial strains, but was bactericidal only against the Gram-positive cocci and Candida spp. In the set experimental parameters, the extract presents antiproliferative, pro-apoptotic, and cytotoxic potential against the MCF-7 human breast cancer cell line.
TI  - Phytochemical Characterization and Evaluation of the Antimicrobial, Antiproliferative and Pro-Apoptotic Potential of Ephedra alata Decne. Hydroalcoholic Extract against the MCF-7 Breast Cancer Cell Line
AV  - public
Y1  - 2019///
UR  - http://publicatio.bibl.u-szeged.hu/15870/
ID  - publicatio15870
SP  - Paper 13
JF  - MOLECULES
ER  -