TY - JOUR EP - 15 p VL - 24 A1 - Danciu Corina A1 - Muntean Delia A1 - Alexa Ersilia A1 - Farcas Claudia A1 - Oprean Camelia A1 - Zupkó István A1 - Bor Andrea A1 - Minda Daliana A1 - Proks Maria A1 - Buda Valentina A1 - Hancianu Monica A1 - Cioanca Oana A1 - Soica Codruta A1 - Popescu Sofia A1 - Dehelean Cristina Adriana IS - 1 SN - 1420-3049 N2 - Ephedra alata Decne. belongs to the Ephedraceae family. It is a species of Ephedra that grows mostly in the desert. Today, the main importance of Ephedra species in the medical field is due to the presence of the alkaloids derived from phenyl-alanine, which act on the sympathetic nervous system as a sympathomimetic. The aim of this study was to conduct a phytochemical characterization of the hydroalcoholic extract of the aerial part of Ephedra alata Decne., which is indigenous to Tunis, that involves the total phenolic content, individual phenolic content, and antioxidant activity as well as a biological screening for the evaluation of the antimicrobial, antifungal, antiproliferative, pro-apoptotic, and cytotoxic potential against the MCF-7 breast cancer cell line. The results show that the hydroalcoholic extract contains polyphenolic phytocompounds (156.226 +/- 0.5 mgGAE/g extract) and elicits antioxidant activity (7453.18 +/- 2.5 mol Trolox/g extract). The extract acted as a bacteriostatic agent against all tested bacterial strains, but was bactericidal only against the Gram-positive cocci and Candida spp. In the set experimental parameters, the extract presents antiproliferative, pro-apoptotic, and cytotoxic potential against the MCF-7 human breast cancer cell line. TI - Phytochemical Characterization and Evaluation of the Antimicrobial, Antiproliferative and Pro-Apoptotic Potential of Ephedra alata Decne. Hydroalcoholic Extract against the MCF-7 Breast Cancer Cell Line AV - public Y1 - 2019/// UR - http://publicatio.bibl.u-szeged.hu/15870/ ID - publicatio15870 SP - Paper 13 JF - MOLECULES ER -