relation: http://publicatio.bibl.u-szeged.hu/14629/
title: Sustainable synthesis of N-methylated peptides in a continuous-flow fixed bed reactor
creator:  Szloszár Aliz
creator:  Mándity István
creator:  Fülöp Ferenc
description: A rapid, simplified and highly efficient continuous-flow solid-phase peptide synthesis technology is reported for the direct synthesis of mono and multiple N-methylated cyclic alanine and valine peptides. Through an optimization study, we find that only 1.5 equivalents of the amino acids are sufficient for the couplings to maintain excellent conversions. Importantly, the technology is outstandingly sustainable, since three chemical steps are cancelled from the procedure and low amount of solvent is used, compared to traditional technologies. Furthermore, it is also applicable to the coupling of challenging amino acids, since pentavalines were constructed with high yield. The technology was successfully upscaled and peptide cyclization was carried out too.
date: 2018
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/14629/1/JFlowChem2018_MI.pdf
identifier:     Szloszár Aliz;  Mándity István;  Fülöp Ferenc: Sustainable synthesis of N-methylated peptides in a continuous-flow fixed bed reactor.   JOURNAL OF FLOW CHEMISTRY, 8 (1).  pp. 21-27.  ISSN 2062-249X (2018)     
identifier: doi:10.1007/s41981-018-0002-9
relation: 3374072
language: eng
relation: info:eu-repo/semantics/altIdentifier/doi/10.1007/s41981-018-0002-9
rights: info:eu-repo/semantics/restrictedAccess