%0 Journal Article
%@ 1567-2018
%A  Léber Attila
%A  Budai-Szűcs Mária
%A  Zsoldiné Urbán Edit
%A  Vályi Péter
%A  Kovács Anita
%A  Berkó Szilvia
%A  Csányi Erzsébet
%A Klinikai Mikrobiológiai Diagnosztikai Intézet SZTE / ÁOK KMDI [2001-],
%A Gyógyszertechnológiai és Gyógyszerfelügyeleti Intézet SZTE / GYTK GYTGYFI [2016-],
%A Gyógyszertechnológiai Intézet [2000-2016],
%A Gyógyszerfelügyeleti Intézet [2000-2016],
%A Klinikai Orvostudományok Doktori Iskola SZTE / DI KODI [2014-],
%A Gyógyszertudományok Doktori Iskola SZTE / DI GYDI [2014-],
%A Konzerváló és Esztétikai Fogászati Tanszék SZTE / FOK KEFT [2012-],
%A Parodontológiai Tanszék SZTE / FOK PT [2008-],
%D 2018
%F publicatio:14428
%J CURRENT DRUG DELIVERY
%N 6
%P 887-897
%T Formulation and Investigation of a Lipid Based Delivery System Containing Antimicrobials for the Treatment of Periodontal Disease
%U http://publicatio.bibl.u-szeged.hu/14428/
%V 15
%X BACKGROUND: Periodontitis is a chronic inflammatory disease, which affects the supporting tissues of the teeth, and without proper treatment it may lead to tooth loss. Antibiotics - dministered orally - have been widely used in the treatment of periodontitis. With the conventional administration routes, adequate drug levels cannot be reached in the periodontal pockets and oral application of antimicrobials could lead to side effects. Drug delivery systems containing antibiotics, administered at the site of infection, could possibly help eliminate pathogen bacteria and treat periodontitis. OBJECTIVE: The aim of the recent study was to create a locally swellable, biodegradable, biocompatible, mucoadhesive, lipophilic drug delivery system (SDLDDS) containing antimicrobial drugs which softens at body temperature, accommodates to the shape of the periodontal pocket and can provide extended drug release for at least one week. METHODS: During the formulation, thermoanalytical, consistency, wettability, swelling, degradation and drug release studies were applied to determine the ideal ratios of lipid bases, structure-building components and surface active agent concentrations. RESULTS AND DISCUSSION: The structure-building component cetostearyl alcohol appeared to be the most convenient thanks to its wettability and mechanical properties, which led to controlled drug release. With the use of ideal concentrations of components (10% surfactant, 40% structure-building component, 32 % lipid base, 15% antimicrobial agent and 3% polymer), sustained drug release can be provided up to nearly 3 weeks.
%Z FELTÖLTŐ: Léber Attila leber.attila@gmail.com Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Szeged, Hungary                         Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Szeged, Hungary                         Department of Periodontology, Faculty of Dentistry, University of Szeged, Szeged, Hungary                         Export Date: 9 January 2019                         Correspondence Address: Csányi, E.; Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös st. 6., Hungary; email: csanyi@pharm.u-szeged.hu                         Chemicals/CAS: amoxicillin, 26787-78-0, 34642-77-8, 61336-70-7; metronidazole, 39322-38-8, 443-48-1; suppocire, 8043-15-0; lipid, 66455-18-3; Anti-Bacterial Agents; Lipids                         Manufacturers: Antibioticos, Spain; Hungaropharma, Hungary