TY  - JOUR
TI  - Dopamine ameliorates bronchoconstriction induced by histaminergic and cholinergic pathways in rabbits
SP  - 156
JF  - RESPIRATORY PHYSIOLOGY AND NEUROBIOLOGY
Y1  - 2019///
N1  - FELTÖLT?: Fodor Gergely fodi666@gmail.com
SN  - 1569-9048
A1  -  Fodor Gergely
A1  -  Balogh Ádám László
A1  -  Südy Roberta
A1  -  Ivánkovitsné Kiss Orsolya
A1  -  Babik Barna
A1  -  Peták Ferenc
N2  - To clarify the potential of dopamine to alter airway tone in the presence of different bronchoconstrictor stimuli, changes in airway function following dopamine administrations were characterized when the bronchial tone was elevated by stimulating the histaminic or cholinergic pathway. Airway resistance, tissue damping and tissue elastance were measured in anesthetized mechanically ventilated rabbits under baseline conditions, during steady-state bronchoconstriction induced by methacholine or histamine, and following intravenous dopamine (5 and 15 ?g/kg/min). Bronchoconstriction induced by methacholine and histamine was significantly ameliorated by dopamine (14.8 ą 2.9% and 14.9 ą 2.9%; p < 0.05 for both), with no difference between the mode of stimuli. Dopamine had no effect on the tissue mechanics. These findings indicate that dopamine relaxes the elevated airway smooth muscle tone without affecting the lung periphery, and this effect is independent of the mode of constrictor stimuli. This profile of dopamine suggests its ability to treat effectively cholinergic and histaminergic bronchoconstriction, besides its positive inotropic effects on the myocardial contractility.
EP  - 161
UR  - http://publicatio.bibl.u-szeged.hu/14114/
AV  - restricted
VL  - 259
ID  - publicatio14114
ER  -