TY  - JOUR
UR  - http://publicatio.bibl.u-szeged.hu/14063/
N1  - FELTÖLT?: Kiss Tivadar kiss.tivadar@pharmacognosy.hu
ID  - publicatio14063
EP  - Azonosító: 3690683
JF  - EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
SP  - Terjedelem: 4 p.
N2  - Rotifers have been widely used as well-characterized models of aging, since their multiorgan character makes them suitable as in vivo toxicological and lifespan models. Here we report the assessment of four adaptogenic plants and their extracts for the first time in this model. The effects on rotifer viability of extracts and characteristic active markers of Panax ginseng, Withania somnifera, Leuzea carthamoides, and Rhodiola rosea were tested in vivo. The crude extracts were nontoxic to Philodina acuticornis bdelloid rotifers; however, the pure substances of the plants influenced negatively the viability. Ginsenoside Rb1 and secondary metabolites of Withania somnifera exerted deleterious effect on the animals. The aglycone tyrosol and cinnamyl alcohol (from Rhodiola rosea) were more toxic than their glycosides salidroside and rosavin. Although the 20-OH-ecdysone and ajugasterone C (from Leuzea carthamoides) are chemically very similar, the latter was less toxic.
A1  -  Mácsai Lilla
A1  -  Datki Zsolt László
A1  -  Csupor Dezs?
A1  -  Horváth Attila
A1  -  Zomborszki Zoltán Péter
TI  - Biological activities of four adaptogenic plant extracts and their active substances on a rotifer model
Y1  - 2018///
VL  - 2018
AV  - public
SN  - 1741-427X
ER  -