relation: http://publicatio.bibl.u-szeged.hu/14063/
title: Biological activities of four adaptogenic plant extracts and their active substances on a rotifer model
creator:  Mácsai Lilla
creator:  Datki Zsolt László
creator:  Csupor Dezső
creator:  Horváth Attila
creator:  Zomborszki Zoltán Péter
description: Rotifers have been widely used as well-characterized models of aging, since their multiorgan character makes them suitable as in vivo toxicological and lifespan models. Here we report the assessment of four adaptogenic plants and their extracts for the first time in this model. The effects on rotifer viability of extracts and characteristic active markers of Panax ginseng, Withania somnifera, Leuzea carthamoides, and Rhodiola rosea were tested in vivo. The crude extracts were nontoxic to Philodina acuticornis bdelloid rotifers; however, the pure substances of the plants influenced negatively the viability. Ginsenoside Rb1 and secondary metabolites of Withania somnifera exerted deleterious effect on the animals. The aglycone tyrosol and cinnamyl alcohol (from Rhodiola rosea) were more toxic than their glycosides salidroside and rosavin. Although the 20-OH-ecdysone and ajugasterone C (from Leuzea carthamoides) are chemically very similar, the latter was less toxic.
date: 2018
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/14063/1/3690683.pdf
identifier:     Mácsai Lilla;  Datki Zsolt László;  Csupor Dezső;  Horváth Attila;  Zomborszki Zoltán Péter: Biological activities of four adaptogenic plant extracts and their active substances on a rotifer model.   EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2018.  Terjedelem: 4 p.-Azonosító: 3690683.  ISSN 1741-427X (2018)     
identifier: doi:10.1155/2018/3690683
relation: 30323215
language: eng
relation: info:eu-repo/semantics/altIdentifier/doi/10.1155/2018/3690683
rights: info:eu-repo/semantics/openAccess