relation: http://publicatio.bibl.u-szeged.hu/12325/
title: Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve
creator:  Radák Zsolt
creator:  Ishihara Kazunari
creator:  Tékus Éva
creator:  Varga Csaba
creator:  Pósa Anikó
creator:  Balogh László
creator:  Boldogh István
creator:  Koltai Erika
description: It is debated whether exercise-induced ROS production is obligatory to cause adaptive response. It is also claimed that antioxidant treatment could eliminate  the adaptive response, which appears to be systemic and reportedly reduces the incidence of a wide range of diseases. Here we suggest that if the antioxidant treatment occurs before the physiological function-ROS dose-response curve reaches peak level, the antioxidants can attenuate function. On the other hand, if the antioxidant treatment takes place after the summit of the bell-shaped dose response curve, antioxidant treatment would have beneficial effects on function.  We suggest that the effects of antioxidant treatment are dependent on the intensity of exercise, since the adaptive response, which is multi pathway dependent, is strongly influenced by exercise intensity. It is further suggested  that levels of ROS concentration are associated with peak physiological function  and can be extended by physical fitness level and this could be the basis for exercise pre-conditioning. Physical inactivity, aging or pathological disorders increase the sensitivity to oxidative stress by altering the bell-shaped dose response curve.
publisher: Elsevier
date: 2017
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/12325/1/Radak_Z_Exercise_oxidants_and_antioxidants_change_the_shape_of_the_bell_shaped_hormesis_curve_u.pdf
identifier:     Radák Zsolt;  Ishihara Kazunari;  Tékus Éva;  Varga Csaba;  Pósa Anikó;  Balogh László;  Boldogh István;  Koltai Erika: Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve.   REDOX BIOLOGY, 12.  pp. 285-290.  (2017)     
identifier: doi:10.1016/j.redox.2017.02.015
relation: 3202562
language: eng
relation: info:eu-repo/semantics/altIdentifier/doi/10.1016/j.redox.2017.02.015
rights: info:eu-repo/semantics/openAccess