%I szte
%D 2016
%O FELTÖLTŐ: Csont Tamás Bálint - csont.tamas@med.u-szeged.hu
%V 30
%T High-dose radiation induced heart damage in a rat model
%P 623-631
%N 5
%R 3105323
%L publicatio11798
%A  KiscsatĂĄri Laura
%A  SĂĄrkĂśzy MĂĄrta
%A  Kővári Bence
%A  Varga ZoltĂĄn
%A  GĂśmĂśri Kamilla
%A  Morvay Nikolett
%A  LeprĂĄn IstvĂĄn
%A  Hegyesi Hargita
%A  FĂĄbiĂĄn Gabriella
%A  Cserni BĂĄlint
%A  Cserni GĂĄbor
%A  Csont TamĂĄs BĂĄlint
%A  KahĂĄn Zsuzsanna
%J IN VIVO
%X BACKGROUND/AIM: Radiation-induced heart disease (RIHD) is a concern during radiotherapy. For its comprehensive study, an in vivo selective heart irradiation model was developed. MATERIALS AND METHODS: Sprague-Dawley rats were irradiated with 50 Gy and functional imaging, biochemical (circulating growth differentiation factor-15 (GDF-15), transforming growth factor-beta (TGF-beta) and morphological (picrosirius red staining of the heart) objectives were tested. RESULTS: Signs and symptoms of RIHD occurred >12 weeks after irradiation with tachypnea, systolic and diastolic dysfunction, cardiac hypertrophy and body development retardation. Plasma GDF-15 was increased 3, 12 and 26, while plasma TGF-beta was increased 12 weeks after irradiation. At autopsy, extensive pleural  fluid was found in the irradiated animals. Interstitial fibrosis could be reliably detected and quantified in irradiated hearts after a follow-up time of 19 weeks. CONCLUSION: The studied parameters could be used in future experiments  for testing protective agents for prevention of radiation heart injury.