TY  - JOUR
N2  - BACKGROUND/AIM: Radiation-induced heart disease (RIHD) is a concern during radiotherapy. For its comprehensive study, an in vivo selective heart irradiation model was developed. MATERIALS AND METHODS: Sprague-Dawley rats were irradiated with 50 Gy and functional imaging, biochemical (circulating growth differentiation factor-15 (GDF-15), transforming growth factor-beta (TGF-beta) and morphological (picrosirius red staining of the heart) objectives were tested. RESULTS: Signs and symptoms of RIHD occurred >12 weeks after irradiation with tachypnea, systolic and diastolic dysfunction, cardiac hypertrophy and body development retardation. Plasma GDF-15 was increased 3, 12 and 26, while plasma TGF-beta was increased 12 weeks after irradiation. At autopsy, extensive pleural  fluid was found in the irradiated animals. Interstitial fibrosis could be reliably detected and quantified in irradiated hearts after a follow-up time of 19 weeks. CONCLUSION: The studied parameters could be used in future experiments  for testing protective agents for prevention of radiation heart injury.
N1  - FELTÖLT?: Csont Tamás Bálint - csont.tamas@med.u-szeged.hu
IS  - 5
JF  - IN VIVO
AV  - restricted
Y1  - 2016///
UR  - http://publicatio.bibl.u-szeged.hu/11798/
VL  - 30
A1  -  Kiscsatári Laura
A1  -  Sárközy Márta
A1  -  K?vári Bence
A1  -  Varga Zoltán
A1  -  Gömöri Kamilla
A1  -  Morvay Nikolett
A1  -  Leprán István
A1  -  Hegyesi Hargita
A1  -  Fábián Gabriella
A1  -  Cserni Bálint
A1  -  Cserni Gábor
A1  -  Csont Tamás Bálint
A1  -  Kahán Zsuzsanna
SN  - 0258-851X
EP  - 631
SP  - 623
TI  - High-dose radiation induced heart damage in a rat model
ID  - publicatio11798
ER  -