%0 Journal Article
%@ 0258-851X
%A  Kiscsatári Laura
%A  Sárközy Márta
%A  Kővári Bence
%A  Varga Zoltán
%A  Gömöri Kamilla
%A  Morvay Nikolett
%A  Leprán István
%A  Hegyesi Hargita
%A  Fábián Gabriella
%A  Cserni Bálint
%A  Cserni Gábor
%A  Csont Tamás Bálint
%A  Kahán Zsuzsanna
%D 2016
%F publicatio:11798
%J IN VIVO
%N 5
%P 623-631
%T High-dose radiation induced heart damage in a rat model
%U http://publicatio.bibl.u-szeged.hu/11798/
%V 30
%X BACKGROUND/AIM: Radiation-induced heart disease (RIHD) is a concern during radiotherapy. For its comprehensive study, an in vivo selective heart irradiation model was developed. MATERIALS AND METHODS: Sprague-Dawley rats were irradiated with 50 Gy and functional imaging, biochemical (circulating growth differentiation factor-15 (GDF-15), transforming growth factor-beta (TGF-beta) and morphological (picrosirius red staining of the heart) objectives were tested. RESULTS: Signs and symptoms of RIHD occurred >12 weeks after irradiation with tachypnea, systolic and diastolic dysfunction, cardiac hypertrophy and body development retardation. Plasma GDF-15 was increased 3, 12 and 26, while plasma TGF-beta was increased 12 weeks after irradiation. At autopsy, extensive pleural  fluid was found in the irradiated animals. Interstitial fibrosis could be reliably detected and quantified in irradiated hearts after a follow-up time of 19 weeks. CONCLUSION: The studied parameters could be used in future experiments  for testing protective agents for prevention of radiation heart injury.
%Z FELTÖLTŐ: Csont Tamás Bálint - csont.tamas@med.u-szeged.hu