relation: http://publicatio.bibl.u-szeged.hu/11594/
title: Short-term beat-to-beat variability of the QT interval is increased and correlates with parameters of left ventricular hypertrophy in patients with hypertrophic cardiomyopathy
creator:  Orosz Andrea
creator:  Baczkó István
creator:  Nagy Viktória
creator:  Gavallér Edit Henriette
creator:  Csanády Miklós
creator:  Forster Tamás
creator:  Papp Gyula
creator:  Varró András
creator:  Lengyel Csaba Attila
creator:  Sepp Róbert
description: Stratification models for the prediction of sudden cardiac death (SCD) are inappropriate in patients with hypertrophic cardiomyopathy (HCM). We investigated conventional electrocardiogram (ECG) repolarization parameters and the beat-to-beat short-term QT interval variability (QT-STV), a new parameter of proarrhythmic risk, in 37 patients with HCM (21 males, average age 48 +/- 15 years). Resting ECGs were recorded for 5 min and the frequency corrected QT interval (QTc), QT dispersion (QTd), beat-to-beat short-term variability of QT interval (QT-STV), and the duration of terminal part of T waves (Tpeak-Tend) were calculated. While all repolarization parameters were significantly increased in patients with HCM compared with the controls (QTc, 488 +/- 61 vs. 434 +/- 23 ms,  p < 0.0001; QT-STV, 4.5 +/- 2 vs. 3.2 +/- 1 ms, p = 0.0002; Tpeak-Tend duration,  107 +/- 27 vs. 91 +/- 10 ms, p = 0.0015; QTd, 47 +/- 17 vs. 34 +/- 9 ms, p = 0.0002), QT-STV had the highest relative increase (+41%). QT-STV also showed the  best correlation with indices of left ventricular (LV) hypertrophy, i.e., maximal LV wall thickness normalized for body surface area (BSA; r = 0.461, p = 0.004) or LV mass (determined by cardiac magnetic resonance imaging) normalized for BSA (r  = 0.455, p = 0.015). In summary, beat-to-beat QT-STV showed the most marked increase in patients with HCM and may represent a novel marker that merits further testing for increased SCD risk in HCM.
date: 2015
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/11594/1/QT_STV_in_HCM_Orosz_et_al_CJPP_2015_u.pdf
identifier:     Orosz Andrea;  Baczkó István;  Nagy Viktória;  Gavallér Edit Henriette;  Csanády Miklós;  Forster Tamás;  Papp Gyula;  Varró András;  Lengyel Csaba Attila;  Sepp Róbert: Short-term beat-to-beat variability of the QT interval is increased and correlates with parameters of left ventricular hypertrophy in patients with hypertrophic cardiomyopathy.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 93 (9).  pp. 765-772.  ISSN 0008-4212 (2015)     
identifier: doi:10.1139/cjpp-2014-0526
relation: 2937124
language: eng
relation: info:eu-repo/semantics/altIdentifier/doi/10.1139/cjpp-2014-0526
rights: info:eu-repo/semantics/restrictedAccess