TY  - JOUR
ID  - publicatio10552
N2  - Kynurenine is a direct precursor of kynurenic acid, the only known endogenous antagonist of excitatory amino acid receptors in the brain. Kynurenine administered intraperitoneally (150, 450, 900 mg/kg) 2 h before pentylenetetrazol injection dose-dependently increased the time to seizures, the time to death and the survivorship of mice. Kynurenine dose-dependently increased the time to seizures and the time to death in mice with NMDLA-induced seizures. Kynurenine, 900 mg/kg, was equally efficacious to diazepam, 2 mg/kg. Probenecid dose-dependently increased the time to seizures, the time to death and the survivorship of mice with pentylenetetrazol-induced seizures. Probenecid had no significant effects on NMDLA-induced seizures, although the time to death was prolonged in the NMDLA 500 mg/kg group. Probenecid potentiated the effects of kynurenine in these tests. Both probenecid and kynurenine significantly increased kynurenine and kynurenic acid concentrations in mouse cerebral cortex and striatum. These findings suggest that kynurenine (metabolized to kynurenic acid) has anticonvulsant effects, and probenecid potentiates these effects in mice.
AV  - restricted
TI  - Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain
Y1  - 1992///
JF  - BRAIN RESEARCH BULLETIN
A1  -  Vécsei László
A1  -  Miller Joanne
A1  -  Macgarvey Usha M.
A1  -  Beal Flint M.
UR  - http://publicatio.bibl.u-szeged.hu/10552/
SN  - 0361-9230
SP  - 233
EP  - 238
VL  - 28
N1  - FELTÖLT?: Gyengéné Ruszka Marian - gyengeneruszka@freemail.hu
ER  -