relation: http://publicatio.bibl.u-szeged.hu/10115/
title: Kynurenine aminotransferase in the supratentorial dura mater of the rat: effect of stimulation of the trigeminal ganglion
creator:  Knyihár-Csillik Erzsébet
creator:  Chadaide Zoltán
creator:  Okuno Etsuo
creator:  Krisztinné Péva Beáta
creator:  Toldi József
creator:  Varga Csaba
creator:  Molnár Andor
creator:  Csillik Bertalan
creator:  Vécsei László
description: Electrical stimulation of the trigeminal ganglion has been widely used as a model of nociception, characterizing migraine. This treatment is known to evoke release of neuropeptides and neurotransmitters from nerve fibers of the dura mater. On the basis of immunocytochemical investigations, we found that under normal conditions, surface membranes of Schwann cells surrounding nerve fibers in the supratentorial dura mater display kynurenine aminotransferase-immunoreaction (KAT-IR); also KAT-IR are the granules of mast cells and the cytoplasms of macrophages (histiocytes). In consequence of stimulation of the trigeminal ganglion, Schwann cells in the dura mater became conspicuously swollen while their KAT-IR decreased considerably; also KAT-IR of mast cells and macrophages decreased significantly. At the same time, nitric oxide synthase (NOS)-IR of nerve fibers in the dura mater increased, suggesting release of nitric oxide (NO), this is-known to be involved in NMDA receptor activation leading to vasodilation followed by neurogenic inflammation. Because kynurenic acid (KYNA) is an antagonist of NMDA receptors, we hypothesize that KYNA and its synthesizing enzyme, KAT, may play a role in the prevention of migraine attacks. (C) 2004 Elsevier Inc. All rights reserved.
date: 2004
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/10115/1/Knyihar_E._Kyn._aminotransferase_u.pdf
identifier:     Knyihár-Csillik Erzsébet;  Chadaide Zoltán;  Okuno Etsuo;  Krisztinné Péva Beáta;  Toldi József;  Varga Csaba;  Molnár Andor;  Csillik Bertalan;  Vécsei László: Kynurenine aminotransferase in the supratentorial dura mater of the rat: effect of stimulation of the trigeminal ganglion.   EXPERIMENTAL NEUROLOGY, 186 (2).  pp. 242-247.  ISSN 0014-4886 (2004)     
identifier: doi:10.1016/j.expneurol.2003.12.001
relation: 1029488
language: eng