TY  - JOUR
N2  - Starting from racemic naringenin ((ą)-1), a mixture of dracocephin A stereoisomers 6-(2?-pyrrolidinone-5?-yl)naringenin (ą)-2a?d and its regioisomer, dracocephin B 8-(2?-pyrrolidinone-5?-yl)naringenin (ą)-3a?d originally isolated from Dracocephalum rupestre, have been synthesized in a one-pot reaction. The separation of 2a?d and 3a?d was achieved by preparative HPLC. The four stereoisomers of each natural product were separated by analytical chiral HPLC and their absolute configuration was studied by the combination of HPLC?ECD measurements and TDDFT?ECD calculations. The synthesized flavonoid alkaloids were further characterized by physicochemical and in vitro pharmacological studies.
ID  - publicatio10062
A1  -  Ilkei Viktor
A1  -  Spaits András
A1  -  Prechl Anita
A1  -  Szigetvári Áron
A1  -  Béni Zoltán
A1  -  Dékány Miklós
A1  -  Szántay Csaba, ifj.
A1  -  Müller Judit
A1  -  Könczöl Árpád
A1  -  Szappanos Ádám
A1  -  Mándi Attila
A1  -  Antus Sándor
A1  -  Martins Ana
A1  -  Hunyadi Attila
A1  -  Balogh György Tibor
A1  -  Kalaus György
A1  -  Bölcskei Hedvig
A1  -  Hazai László
A1  -  Kurtán Tibor
AV  - public
EP  - 2534
SP  - 2523
UR  - http://publicatio.bibl.u-szeged.hu/10062/
JF  - BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
VL  - 12
Y1  - 2016///
N1  - FELTÖLT?: Kiss Tivadar - kiss.tivadar@pharmacognosy.hu
TI  - Biomimetic synthesis and HPLC?ECD analysis of the isomers of dracocephins A and B
SN  - 1860-5397
ER  -