%0 Journal Article
%@ 1860-5397
%A  Ilkei Viktor
%A  Spaits András
%A  Prechl Anita
%A  Szigetvári Áron
%A  Béni Zoltán
%A  Dékány Miklós
%A  Szántay Csaba, ifj.
%A  Müller Judit
%A  Könczöl Árpád
%A  Szappanos Ádám
%A  Mándi Attila
%A  Antus Sándor
%A  Martins Ana
%A  Hunyadi Attila
%A  Balogh György Tibor
%A  Kalaus György
%A  Bölcskei Hedvig
%A  Hazai László
%A  Kurtán Tibor
%A DE/TTK/KemI/Szerves Kémiai Tanszék,
%A SZTE/GYTK/Farmakognóziai Intézet,
%D 2016
%F publicatio:10062
%J BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
%P 2523-2534
%T Biomimetic synthesis and HPLC–ECD analysis of the isomers of dracocephins A and B
%U http://publicatio.bibl.u-szeged.hu/10062/
%V 12
%X Starting from racemic naringenin ((±)-1), a mixture of dracocephin A stereoisomers 6-(2”-pyrrolidinone-5”-yl)naringenin (±)-2a–d and its regioisomer, dracocephin B 8-(2”-pyrrolidinone-5”-yl)naringenin (±)-3a–d originally isolated from Dracocephalum rupestre, have been synthesized in a one-pot reaction. The separation of 2a–d and 3a–d was achieved by preparative HPLC. The four stereoisomers of each natural product were separated by analytical chiral HPLC and their absolute configuration was studied by the combination of HPLC–ECD measurements and TDDFT–ECD calculations. The synthesized flavonoid alkaloids were further characterized by physicochemical and in vitro pharmacological studies.
%Z FELTÖLTŐ: Kiss Tivadar - kiss.tivadar@pharmacognosy.hu