relation: http://publicatio.bibl.u-szeged.hu/10062/
title: Biomimetic synthesis and HPLC–ECD analysis of the isomers of dracocephins A and B
creator:  Ilkei Viktor
creator:  Spaits András
creator:  Prechl Anita
creator:  Szigetvári Áron
creator:  Béni Zoltán
creator:  Dékány Miklós
creator:  Szántay Csaba, ifj.
creator:  Müller Judit
creator:  Könczöl Árpád
creator:  Szappanos Ádám
creator:  Mándi Attila
creator:  Antus Sándor
creator:  Martins Ana
creator:  Hunyadi Attila
creator:  Balogh György Tibor
creator:  Kalaus György
creator:  Bölcskei Hedvig
creator:  Hazai László
creator:  Kurtán Tibor
description: Starting from racemic naringenin ((±)-1), a mixture of dracocephin A stereoisomers 6-(2”-pyrrolidinone-5”-yl)naringenin (±)-2a–d and its regioisomer, dracocephin B 8-(2”-pyrrolidinone-5”-yl)naringenin (±)-3a–d originally isolated from Dracocephalum rupestre, have been synthesized in a one-pot reaction. The separation of 2a–d and 3a–d was achieved by preparative HPLC. The four stereoisomers of each natural product were separated by analytical chiral HPLC and their absolute configuration was studied by the combination of HPLC–ECD measurements and TDDFT–ECD calculations. The synthesized flavonoid alkaloids were further characterized by physicochemical and in vitro pharmacological studies.
date: 2016
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/10062/1/1860_5397_12_247_u.pdf
identifier:     Ilkei Viktor;  Spaits András;  Prechl Anita;  Szigetvári Áron;  Béni Zoltán;  Dékány Miklós;  Szántay Csaba, ifj.;  Müller Judit;  Könczöl Árpád;  Szappanos Ádám;  Mándi Attila;  Antus Sándor;  Martins Ana;  Hunyadi Attila;  Balogh György Tibor;  Kalaus György;  Bölcskei Hedvig;  Hazai László;  Kurtán Tibor: Biomimetic synthesis and HPLC–ECD analysis of the isomers of dracocephins A and B.   BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 12.  pp. 2523-2534.  ISSN 1860-5397 (2016)     
identifier: doi:10.3762/bjoc.12.247
relation: 3143287
language: eng