%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Kata Szántó, Tibor Nyári, Anita Bálint, Renáta Bor, Ágnes Milassin, Mariann Rutka, Anna Fábián, Zoltán Szepes, Ferenc Nagy, Tamás Molnár, Klaudia Farkas
Biological therapy and surgery rates in inflammatory bowel diseases – Data analysis of almost 1000 patients from a Hungarian tertiary IBD center
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 13 0 R/Contents 14 0 R/TrimBox[0 0 612 792]>>
endobj
13 0 obj
[15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R]
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref002)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref003)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref004)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref005)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref006)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref007)>>
endobj
21 0 obj
<>/Border[0 0 0]/A 23 0 R>>
endobj
23 0 obj
<>
endobj
22 0 obj
<>/Border[0 0 0]/A 24 0 R>>
endobj
24 0 obj
<>
endobj
14 0 obj
[25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R]
endobj
25 0 obj
<>stream
q
0.83 0.64 0.02 0 k
437.4992 693.2976 m
442.2047 693.2976 l
h
f*
299.452 667.3323 m
304.2142 667.3323 l
h
f*
490.337 309.6 m
495.0992 309.6 l
h
f*
374.4567 296.6173 m
379.2189 296.6173 l
h
f*
474.8031 283.6346 m
479.5087 283.6346 l
h
f*
483.9874 283.6346 m
488.7496 283.6346 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(these)Tj
2.2506 0 Td
(new)Tj
1.8766 0 Td
(therapeutic)Tj
4.7338 0 Td
(approaches)Tj
4.7395 0 Td
(is)Tj
0.8447 0 Td
(to)Tj
1.0261 0 Td
(favorably)Tj
3.9175 0 Td
(modify)Tj
3.0841 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(natural)Tj
3.0784 0 Td
(history)Tj
3.0047 0 Td
(of)Tj
1.0148 0 Td
(IBD,)Tj
2.1033 0 Td
(hope-)Tj
-34.1799 -1.3039 Td
(fully)Tj
1.9842 0 Td
(resulting)Tj
3.7247 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.6519 0 Td
(decrease)Tj
3.6113 0 Td
(in)Tj
1.0318 0 Td
(complications)Tj
5.8451 0 Td
(and)Tj
1.7291 0 Td
(surgeries)Tj
3.7927 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
1.5987 0 Td
(However,)Tj
4.0762 0 Td
(since)Tj
2.2451 0 Td
(the)Tj
1.4683 0 Td
(prevalence)Tj
-32.7966 -1.2982 Td
(of)Tj
1.0147 0 Td
(IBD)Tj
1.8766 0 Td
(is)Tj
0.8447 0 Td
(expected)Tj
3.7247 0 Td
(to)Tj
1.0261 0 Td
(increase,)Tj
3.6964 0 Td
(direct)Tj
2.5341 0 Td
(and)Tj
1.7292 0 Td
(indirect)Tj
3.3448 0 Td
(costs)Tj
2.1713 0 Td
(to)Tj
1.0262 0 Td
(both)Tj
2.0579 0 Td
(health)Tj
2.6816 0 Td
(care)Tj
1.8708 0 Td
(system)Tj
2.9367 0 Td
(and)Tj
1.7291 0 Td
(society)Tj
-34.2649 -1.2983 Td
(will)Tj
1.661 0 Td
(also)Tj
1.7688 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(increased)Tj
3.9969 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(].)Tj
-8.4075 -1.2983 Td
(Descriptive)Tj
4.7678 0 Td
(epidemiologic)Tj
5.879 0 Td
(studies)Tj
2.9877 0 Td
(and)Tj
1.7291 0 Td
(population-based)Tj
7.1943 0 Td
(cohort)Tj
2.8573 0 Td
(studies)Tj
2.9821 0 Td
(can)Tj
1.627 0 Td
(provide)Tj
3.2882 0 Td
(valu-)Tj
-34.5087 -1.3039 Td
(able)Tj
1.8311 0 Td
(information)Tj
5.074 0 Td
(about)Tj
2.4945 0 Td
(the)Tj
1.4683 0 Td
(burden)Tj
3.1294 0 Td
(of)Tj
1.0148 0 Td
(illness)Tj
2.6703 0 Td
(since)Tj
2.245 0 Td
(identification)Tj
5.5842 0 Td
(of)Tj
1.0148 0 Td
(simple)Tj
2.8573 0 Td
(demographic)Tj
5.5048 0 Td
(and)Tj
-34.8885 -1.2982 Td
(clinical)Tj
3.0727 0 Td
(factors)Tj
2.9026 0 Td
(associated)Tj
4.2577 0 Td
(with)Tj
2.0012 0 Td
(disabling)Tj
3.8438 0 Td
(disease)Tj
3.016 0 Td
(has)Tj
1.542 0 Td
(high)Tj
2.007 0 Td
(importance)Tj
4.8302 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(management)Tj
5.4368 0 Td
(of)Tj
-35.4158 -1.2983 Td
(IBD.)Tj
2.0976 0 Td
(However,)Tj
4.0818 0 Td
(only)Tj
1.9729 0 Td
(limited)Tj
3.0728 0 Td
(data)Tj
1.9105 0 Td
(are)Tj
1.4513 0 Td
(available)Tj
3.6681 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4683 0 Td
(Eastern)Tj
3.2258 0 Td
(Europe)Tj
3.1351 0 Td
(regarding)Tj
4.0932 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(rate)Tj
1.7518 0 Td
(of)Tj
-36.629 -1.3039 Td
(more)Tj
2.3414 0 Td
(complicated)Tj
5.108 0 Td
(disease)Tj
3.016 0 Td
(course,)Tj
3.0614 0 Td
(use)Tj
1.5307 0 Td
(of)Tj
1.0148 0 Td
(biological)Tj
4.0875 0 Td
(therapy)Tj
3.2485 0 Td
(and)Tj
1.7291 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(surgeries.)Tj
-28.3746 -1.2983 Td
(The)Tj
/F10 1 Tf
1.7858 0 Td
(aim)Tj
/F5 1 Tf
1.8141 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6725 0 Td
(study)Tj
2.3924 0 Td
(was)Tj
1.6951 0 Td
(to)Tj
1.0261 0 Td
(determine)Tj
4.3257 0 Td
(demographic)Tj
5.5048 0 Td
(features,)Tj
3.5717 0 Td
(disease)Tj
3.016 0 Td
(phenotypes,)Tj
5.023 0 Td
(medical)Tj
-34.0382 -1.2983 Td
(and)Tj
1.7291 0 Td
(surgical)Tj
3.3165 0 Td
(therapies)Tj
3.8437 0 Td
(in)Tj
1.0375 0 Td
(our)Tj
1.6214 0 Td
(large)Tj
2.16 0 Td
(IBD)Tj
1.8765 0 Td
(patients')Tj
3.583 0 Td
(registry)Tj
3.2371 0 Td
(and)Tj
1.7292 0 Td
(to)Tj
1.0261 0 Td
(identify)Tj
3.2938 0 Td
(which)Tj
2.6476 0 Td
(parameters)Tj
4.6771 0 Td
(are)Tj
-35.7786 -1.3039 Td
(in)Tj
1.0318 0 Td
(association)Tj
4.6317 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.4684 0 Td
(need)Tj
2.1429 0 Td
(of)Tj
1.0148 0 Td
(surgery)Tj
3.1975 0 Td
(and/or)Tj
2.9367 0 Td
(biologic)Tj
3.4129 0 Td
(therapy)Tj
3.2428 0 Td
(as)Tj
1.0148 0 Td
(surrogate)Tj
3.9798 0 Td
(markers)Tj
3.4979 0 Td
(of)Tj
1.0148 0 Td
(worse)Tj
-34.5824 -1.2982 Td
(disease)Tj
3.016 0 Td
(course)Tj
2.8346 0 Td
(in)Tj
1.0375 0 Td
(CD)Tj
1.6157 0 Td
(and)Tj
1.7292 0 Td
(UC.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 522.7086 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Patients)Tj
4.0724 0 Td
(and)Tj
1.9937 0 Td
(methods)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 505.7007 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Patients)Tj
3.4072 0 Td
(diagnosed)Tj
4.2803 0 Td
(with)Tj
2.0012 0 Td
(IBD)Tj
1.8765 0 Td
(have)Tj
2.058 0 Td
(been)Tj
2.1203 0 Td
(prospectively)Tj
5.4878 0 Td
(participated)Tj
5.0003 0 Td
(in)Tj
1.0375 0 Td
(an)Tj
1.2019 0 Td
(IBD)Tj
1.8765 0 Td
(registry)Tj
3.2315 0 Td
(launched)Tj
-33.579 -1.2982 Td
(at)Tj
0.9524 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 214.2992 497.1401 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(st)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 221.3858 492.7181 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Department)Tj
5.0909 0 Td
(of)Tj
1.0148 0 Td
(Medicine,)Tj
4.2236 0 Td
(University)Tj
4.3994 0 Td
(of)Tj
1.0148 0 Td
(Szeged)Tj
2.948 0 Td
(in)Tj
1.0375 0 Td
(2007.)Tj
2.347 0 Td
(This)Tj
1.9899 0 Td
(is)Tj
0.8448 0 Td
(large,)Tj
2.3867 0 Td
(prospectively)Tj
5.4822 0 Td
(main-)Tj
-34.9169 -1.3039 Td
(tained)Tj
2.7155 0 Td
(database)Tj
3.6397 0 Td
(that)Tj
1.7801 0 Td
(captures)Tj
3.5773 0 Td
(demographic)Tj
5.5049 0 Td
(and)Tj
1.7291 0 Td
(clinical)Tj
3.0784 0 Td
(data)Tj
1.9105 0 Td
(including)Tj
4.0422 0 Td
(intestinal)Tj
3.9118 0 Td
(and)Tj
1.7291 0 Td
(extrain-)Tj
-33.6186 -1.2982 Td
(testinal)Tj
3.0954 0 Td
(symptoms,)Tj
4.5864 0 Td
(disease)Tj
3.016 0 Td
(activity)Tj
3.1181 0 Td
(assessed)Tj
3.4696 0 Td
(by)Tj
1.1849 0 Td
(validated)Tj
3.8324 0 Td
(activity)Tj
3.1181 0 Td
(scores,)Tj
2.8913 0 Td
(previous)Tj
3.651 0 Td
(and)Tj
1.7291 0 Td
(current)Tj
-33.6923 -1.2983 Td
(therapies,)Tj
4.0705 0 Td
(laboratory)Tj
4.3483 0 Td
(results)Tj
2.8063 0 Td
(and)Tj
1.7348 0 Td
(physiological)Tj
5.4424 0 Td
(parameters)Tj
4.6715 0 Td
(like)Tj
1.6554 0 Td
(blood)Tj
2.5115 0 Td
(pressure,)Tj
3.8041 0 Td
(heart)Tj
2.2734 0 Td
(rate,)Tj
1.9729 0 Td
(body)Tj
-35.2911 -1.3039 Td
(weight)Tj
2.8856 0 Td
(and)Tj
1.7291 0 Td
(height,)Tj
2.9537 0 Td
(results)Tj
2.8119 0 Td
(of)Tj
1.0148 0 Td
(physical)Tj
3.4526 0 Td
(investigations,)Tj
5.9471 0 Td
(findings)Tj
3.4922 0 Td
(of)Tj
1.0148 0 Td
(endoscopies)Tj
5.0854 0 Td
(and)Tj
1.7291 0 Td
(imaging)Tj
-32.1163 -1.2983 Td
(methods)Tj
3.685 0 Td
(at)Tj
0.9524 0 Td
(every)Tj
2.3471 0 Td
(appointment)Tj
5.3971 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(patients.)Tj
3.5886 0 Td
(The)Tj
1.7859 0 Td
(registry)Tj
3.2314 0 Td
(includes)Tj
3.5433 0 Td
(both)Tj
2.0636 0 Td
(incident)Tj
3.5206 0 Td
(and)Tj
1.7348 0 Td
(preva-)Tj
-34.3386 -1.2982 Td
(lent)Tj
1.7348 0 Td
(cases.)Tj
2.4491 0 Td
(This)Tj
1.9842 0 Td
(database)Tj
3.6397 0 Td
(is)Tj
0.8503 0 Td
(suitable)Tj
3.2825 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(follow-up)Tj
4.0932 0 Td
(of)Tj
1.0148 0 Td
(patients)Tj
3.3676 0 Td
(since)Tj
2.245 0 Td
(it)Tj
0.788 0 Td
(records)Tj
3.2032 0 Td
(every)Tj
2.347 0 Td
(visit)Tj
1.8709 0 Td
(of)Tj
-35.7276 -1.2983 Td
(the)Tj
1.4684 0 Td
(patient)Tj
3.0046 0 Td
(with)Tj
2.0012 0 Td
(all)Tj
1.1452 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(important)Tj
4.2802 0 Td
(and)Tj
1.7348 0 Td
(necessary)Tj
4.0195 0 Td
(information)Tj
5.074 0 Td
(detailed)Tj
3.3676 0 Td
(above.)Tj
-27.3824 -1.3039 Td
(In)Tj
1.111 0 Td
(this)Tj
1.6725 0 Td
(study)Tj
2.3924 0 Td
(clinical)Tj
3.0727 0 Td
(data)Tj
1.9162 0 Td
(and)Tj
1.7292 0 Td
(descriptive)Tj
4.558 0 Td
(statistics)Tj
3.5887 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(IBD)Tj
1.8765 0 Td
(outpatients)Tj
4.6998 0 Td
(were)Tj
2.126 0 Td
(extracted)Tj
-32.4224 -1.2983 Td
(and)Tj
1.7292 0 Td
(analyzed)Tj
3.7019 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4684 0 Td
(IBD)Tj
1.8765 0 Td
(registry)Tj
3.2315 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 371.7921 380.1259 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(st)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 378.8787 375.7039 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Department)Tj
5.0909 0 Td
(of)Tj
1.0148 0 Td
(Medicine,)Tj
4.218 0 Td
(University)Tj
4.405 0 Td
(of)Tj
1.0148 0 Td
(Szeged)Tj
-33.63 -1.2982 Td
(between)Tj
3.5263 0 Td
(January)Tj
3.3222 0 Td
(2007)Tj
2.1203 0 Td
(and)Tj
1.7291 0 Td
(March)Tj
2.8687 0 Td
(2015.)Tj
2.3527 0 Td
(Present)Tj
3.203 0 Td
(age,)Tj
1.7689 0 Td
(age)Tj
1.542 0 Td
(at)Tj
0.9524 0 Td
(diagnosis)Tj
3.9572 0 Td
(and)Tj
1.7291 0 Td
(at)Tj
0.9524 0 Td
(onset,)Tj
2.5852 0 Td
(smoking)Tj
-32.6095 -1.3039 Td
(habits,)Tj
2.8403 0 Td
(history)Tj
3.0048 0 Td
(of)Tj
1.0147 0 Td
(appendectomy,)Tj
6.3439 0 Td
(the)Tj
1.4684 0 Td
(presence)Tj
3.7132 0 Td
(of)Tj
1.0148 0 Td
(familial)Tj
3.2202 0 Td
(IBD,)Tj
2.1033 0 Td
(the)Tj
1.4683 0 Td
(presence)Tj
3.7134 0 Td
(of)Tj
1.0148 0 Td
(extraintestinal)Tj
-30.9201 -1.2983 Td
(manifestations,)Tj
6.2986 0 Td
(disease)Tj
3.0217 0 Td
(activities,)Tj
3.9345 0 Td
(number)Tj
3.4185 0 Td
(and)Tj
1.7347 0 Td
(type)Tj
1.9106 0 Td
(of)Tj
1.0148 0 Td
(surgeries,)Tj
4.0195 0 Td
(most)Tj
2.2053 0 Td
(important)Tj
4.2803 0 Td
(laboratory)Tj
-31.8385 -1.2983 Td
(parameters)Tj
4.6715 0 Td
(and)Tj
1.7291 0 Td
(therapies)Tj
3.8438 0 Td
(were)Tj
2.126 0 Td
(registered)Tj
4.1499 0 Td
(at)Tj
0.9524 0 Td
(every)Tj
2.347 0 Td
(appointment)Tj
5.4028 0 Td
(of)Tj
1.0148 0 Td
(each)Tj
2.0296 0 Td
(patient.)Tj
3.2314 0 Td
(The)Tj
1.7802 0 Td
(diagnosis)Tj
-33.2785 -1.3039 Td
(of)Tj
1.0148 0 Td
(CD)Tj
1.6158 0 Td
(and)Tj
1.7348 0 Td
(UC)Tj
1.6157 0 Td
(was)Tj
1.7008 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(Lennard-Jones)Tj
6.134 0 Td
(and)Tj
1.7292 0 Td
(later)Tj
1.9955 0 Td
(ECCO)Tj
2.863 0 Td
(criteria)Tj
3.0728 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(];)Tj
1.6044 0 Td
(disease)Tj
3.016 0 Td
(phenotype)Tj
-33.3125 -1.2982 Td
(was)Tj
1.6952 0 Td
(defined)Tj
3.2314 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4684 0 Td
(Montreal)Tj
3.9401 0 Td
(Classification)Tj
5.5899 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(].)Tj
1.5986 0 Td
(Disease)Tj
3.2258 0 Td
(activity)Tj
3.1181 0 Td
(was)Tj
1.7008 0 Td
(assessed)Tj
3.4696 0 Td
(by)Tj
1.1849 0 Td
(the)Tj
1.4683 0 Td
(Crohn's)Tj
-32.8703 -1.2983 Td
(Disease)Tj
3.2259 0 Td
(Activity)Tj
3.3675 0 Td
(Index)Tj
2.5228 0 Td
(\(CDAI\))Tj
3.3279 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(Mayo)Tj
2.5057 0 Td
(Scoring)Tj
3.2825 0 Td
(System)Tj
3.0501 0 Td
(in)Tj
1.0375 0 Td
(UC)Tj
1.6214 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2585 0 Td
(7)Tj
0 g
(].)Tj
1.2586 0 Td
(On)Tj
1.5194 0 Td
(the)Tj
1.4683 0 Td
(basis)Tj
2.1487 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-35.807 -1.3039 Td
(activity)Tj
3.1125 0 Td
(scores,)Tj
2.8856 0 Td
(patients)Tj
3.3676 0 Td
(were)Tj
2.1146 0 Td
(divided)Tj
3.2088 0 Td
(in)Tj
1.0318 0 Td
(inactive,)Tj
3.5602 0 Td
(mildly,)Tj
2.999 0 Td
(moderately)Tj
4.7225 0 Td
(and)Tj
1.7291 0 Td
(severely)Tj
3.3732 0 Td
(active)Tj
2.5172 0 Td
(groups.)Tj
-34.6221 -1.2983 Td
(CRP)Tj
2.0637 0 Td
(was)Tj
1.7007 0 Td
(considered)Tj
4.5978 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(abnormal)Tj
4.0875 0 Td
(referring)Tj
3.7473 0 Td
(to)Tj
1.0261 0 Td
(active)Tj
2.5229 0 Td
(disease)Tj
3.016 0 Td
(if)Tj
0.7767 0 Td
(being)Tj
2.4321 0 Td
(higher)Tj
2.8006 0 Td
(than)Tj
2.0296 0 Td
(5)Tj
0.6973 0 Td
(mg/l)Tj
2.0806 0 Td
(both)Tj
-35.7559 -1.2983 Td
(in)Tj
1.0319 0 Td
(UC)Tj
1.6214 0 Td
(and)Tj
1.7291 0 Td
(CD.)Tj
1.8482 0 Td
(In)Tj
1.1055 0 Td
(the)Tj
1.474 0 Td
(majority)Tj
3.6283 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(patients,)Tj
3.5942 0 Td
(first)Tj
1.8029 0 Td
(attendance)Tj
4.5807 0 Td
(at)Tj
0.9525 0 Td
(the)Tj
1.4683 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 477.9779 250.1291 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(st)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 485.1212 245.707 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Department)Tj
5.0909 0 Td
(of)Tj
1.0148 0 Td
(Medi-)Tj
-34.6163 -1.2982 Td
(cine,)Tj
2.1089 0 Td
(University)Tj
4.3994 0 Td
(of)Tj
1.0148 0 Td
(Szeged)Tj
2.948 0 Td
(was)Tj
1.7008 0 Td
(the)Tj
1.4683 0 Td
(same)Tj
2.262 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(time)Tj
2.0296 0 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(diagnosis.)Tj
4.1839 0 Td
(Worse)Tj
2.8459 0 Td
(disease)Tj
3.016 0 Td
(course)Tj
2.8346 0 Td
(was)Tj
-35.7785 -1.3039 Td
(characterized)Tj
5.5558 0 Td
(by)Tj
1.1849 0 Td
(active)Tj
2.5172 0 Td
(disease)Tj
3.0217 0 Td
(with)Tj
1.9955 0 Td
(or)Tj
1.0999 0 Td
(without)Tj
3.3278 0 Td
(extraintestinal)Tj
5.9074 0 Td
(complications)Tj
5.8392 0 Td
(or)Tj
1.0999 0 Td
(perianal)Tj
3.4582 0 Td
(mani-)Tj
-35.0075 -1.2983 Td
(festations)Tj
4.0025 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4683 0 Td
(need)Tj
2.143 0 Td
(of)Tj
1.0148 0 Td
(biological)Tj
4.0875 0 Td
(therapy)Tj
3.2485 0 Td
(and/or)Tj
2.9367 0 Td
(major)Tj
2.6135 0 Td
(surgery.)Tj
-22.0534 -1.2983 Td
(Differences)Tj
4.7792 0 Td
(in)Tj
1.0318 0 Td
(demographic)Tj
5.5048 0 Td
(and)Tj
1.7291 0 Td
(clinical)Tj
3.0784 0 Td
(characteristics,)Tj
6.1285 0 Td
(the)Tj
1.4683 0 Td
(presence)Tj
3.7133 0 Td
(of)Tj
1.0148 0 Td
(extraintestinal)Tj
-29.6444 -1.3039 Td
(manifestations,)Tj
6.2985 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(surgeries)Tj
3.7927 0 Td
(and)Tj
1.7291 0 Td
(different)Tj
3.6567 0 Td
(types)Tj
2.2734 0 Td
(of)Tj
1.0148 0 Td
(treatments)Tj
4.4957 0 Td
(between)Tj
3.5318 0 Td
(CD)Tj
1.6214 0 Td
(and)Tj
1.7292 0 Td
(UC)Tj
-34.5767 -1.2982 Td
(and)Tj
1.7291 0 Td
(predictors)Tj
4.2859 0 Td
(of)Tj
1.0148 0 Td
(outcomes)Tj
4.0876 0 Td
(in)Tj
1.0374 0 Td
(both)Tj
2.058 0 Td
(diseases)Tj
3.3789 0 Td
(were)Tj
2.1259 0 Td
(analyzed)Tj
3.7021 0 Td
(statistically.)Tj
4.8358 0 Td
(Of)Tj
1.2528 0 Td
(therapies,)Tj
4.0706 0 Td
(cortico-)Tj
-33.5789 -1.2983 Td
(steroid,)Tj
3.1974 0 Td
(immunosuppressive)Tj
8.2998 0 Td
(and)Tj
1.7291 0 Td
(biological)Tj
4.0876 0 Td
(therapies)Tj
3.8437 0 Td
(were)Tj
2.126 0 Td
(collected)Tj
3.736 0 Td
(for)Tj
1.389 0 Td
(statistical)Tj
3.906 0 Td
(analysis.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 125.9716 cm
BT
/F10 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Statistical)Tj
4.3228 0 Td
(analysis)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 109.0204 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Statistical)Tj
4.0195 0 Td
(analysis)Tj
3.3278 0 Td
(was)Tj
1.7008 0 Td
(carried)Tj
3.0387 0 Td
(out)Tj
1.5534 0 Td
(using)Tj
2.3867 0 Td
(STATA)Tj
3.2882 0 Td
(9.0)Tj
1.3946 0 Td
(software.)Tj
3.8154 0 Td
(The)Tj
1.7802 0 Td
(Pearson's)Tj
4.0025 0 Td
(chi-square)Tj
4.4107 0 Td
(test,)Tj
-34.7185 -1.3039 Td
(Wilcoxon)Tj
4.1498 0 Td
(ranksum)Tj
3.7758 0 Td
(test,)Tj
1.8311 0 Td
(Kruskal-Wallis)Tj
6.1965 0 Td
(test)Tj
1.6044 0 Td
(and)Tj
1.7292 0 Td
(logrank)Tj
3.2881 0 Td
(test)Tj
1.5988 0 Td
(were)Tj
2.1259 0 Td
(performed)Tj
4.4674 0 Td
(to)Tj
1.0261 0 Td
(analyze)Tj
3.1748 0 Td
(data.)Tj
-34.9679 -1.2982 Td
(Median)Tj
3.3108 0 Td
(follow-up)Tj
4.0932 0 Td
(time)Tj
2.0296 0 Td
(with)Tj
2.0012 0 Td
(middle)Tj
3.0274 0 Td
(50%)Tj
1.9276 0 Td
(interquartile)Tj
5.2043 0 Td
(range)Tj
2.4662 0 Td
(\(IQR50%\))Tj
4.3143 0 Td
(were)Tj
2.1259 0 Td
(calculated.)Tj
4.4277 0 Td
(The)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 417.3165 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Disease)Tj
3.7701 0 Td
(outcome)Tj
3.9968 0 Td
(in)Tj
0.978 0 Td
(IBD)Tj
1.8638 0 Td
(in)Tj
0.978 0 Td
(a)Tj
0.7653 0 Td
(Hungarian)Tj
4.7481 0 Td
(center)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.02008)Tj
4.089 0 Td
(24)Tj
0 g
2.0906 0 Td
(July)Tj
1.9701 0 Td
(30,)Tj
1.5874 0 Td
(2018)Tj
35.894 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(8)Tj
ET
Q
q
0.83 0.64 0.02 0 k
1 j
1 J
0 w
36 707.6409 m
165.3732 707.6409 l
h
f*
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F8 1 Tf
1 TL
-0.025 Tc
0 0 Td
(16-2017-0)Tj
3.926 0 Td
(0006/efop-3-)Tj
4.8614 0 Td
(6-2-16-2017-)Tj
5.0174 0 Td
(00006)Tj
0 g
(\).)Tj
3.1181 0 Td
(The)Tj
-16.9229 -1.3748 Td
(funders)Tj
3.0472 0 Td
(had)Tj
1.5874 0 Td
(no)Tj
1.1693 0 Td
(role)Tj
1.6087 0 Td
(in)Tj
0.8929 0 Td
(study)Tj
2.2607 0 Td
(design,)Tj
2.8984 0 Td
(data)Tj
1.793 0 Td
(collection)Tj
-15.2576 -1.3748 Td
(and)Tj
1.5874 0 Td
(analysis,)Tj
3.4087 0 Td
(decision)Tj
3.2953 0 Td
(to)Tj
0.9496 0 Td
(publish)Tj
2.9197 0 Td
(or)Tj
0.9992 0 Td
(preparation)Tj
4.4433 0 Td
(of)Tj
-17.6032 -1.3748 Td
(the)Tj
1.3677 0 Td
(manuscript.)Tj
/F7 1 Tf
-1.3677 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F8 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3748 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
26 0 obj
<>stream
endstream
endobj
27 0 obj
<>stream
endstream
endobj
28 0 obj
<>stream
endstream
endobj
29 0 obj
<>stream
endstream
endobj
30 0 obj
<>stream
endstream
endobj
31 0 obj
<>stream
endstream
endobj
32 0 obj
<>stream
endstream
endobj
33 0 obj
<>stream
BT
10.3394 -7.6252 Td
(exist.)Tj
ET
Q
endstream
endobj
34 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 38 0 R/Contents 39 0 R/TrimBox[0 0 612 792]>>
endobj
38 0 obj
[40 0 R]
endobj
40 0 obj
<>/Border[0 0 0]/A 41 0 R>>
endobj
41 0 obj
<>
endobj
39 0 obj
[42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R]
endobj
42 0 obj
<>stream
q
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(symptom)Tj
3.9968 0 Td
(free)Tj
1.7234 0 Td
(follow-up)Tj
4.0989 0 Td
(periods)Tj
3.1918 0 Td
(were)Tj
2.1203 0 Td
(compared)Tj
4.2463 0 Td
(using)Tj
2.3924 0 Td
(Kaplan-Meier)Tj
5.7996 0 Td
(product)Tj
3.3959 0 Td
(limit)Tj
2.1147 0 Td
(estimator.)Tj
-33.0801 -1.3039 Td
(A)Tj
0.9014 0 Td
(probability)Tj
4.5977 0 Td
(level)Tj
2.0126 0 Td
(of)Tj
1.0148 0 Td
(p)Tj
/F11 1 Tf
0 Tc
(<)Tj
/F5 1 Tf
-0.004 Tc
(0.05)Tj
3.1635 0 Td
(was)Tj
1.7007 0 Td
(considered)Tj
4.5978 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(significant.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 665.9149 cm
BT
/F10 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Ethical)Tj
3.1417 0 Td
(approval)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 648.907 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(This)Tj
1.9842 0 Td
(study)Tj
2.3924 0 Td
(was)Tj
1.6951 0 Td
(approved)Tj
3.9742 0 Td
(by)Tj
1.1848 0 Td
(the)Tj
1.4684 0 Td
(Clinical)Tj
3.3165 0 Td
(Research)Tj
3.8041 0 Td
(Coordination)Tj
5.6692 0 Td
(Center)Tj
2.948 0 Td
(University)Tj
4.3994 0 Td
(of)Tj
1.0148 0 Td
(Szeged)Tj
-33.8511 -1.2982 Td
(Faculty)Tj
3.1294 0 Td
(of)Tj
1.0148 0 Td
(Medicine)Tj
3.9968 0 Td
(Albert)Tj
2.7496 0 Td
(Szent-Gyo)Tj
0 Tc
3.7417 0 Td
()Tj
-0.004 Tc
0.4422 0 Td
(rgyi)Tj
1.7801 0 Td
(Health)Tj
2.9197 0 Td
(Center.)Tj
3.1748 0 Td
(Number)Tj
3.6056 0 Td
(of)Tj
1.0148 0 Td
(ethical)Tj
2.8403 0 Td
(licence:)Tj
3.1975 0 Td
(2640)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 607.4645 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Results)Tj
/F10 1 Tf
0 -1.5023 Td
(Demographic)Tj
5.9291 0 Td
(data)Tj
2.0363 0 Td
(and)Tj
1.7905 0 Td
(clinical)Tj
3.2221 0 Td
(characteristics)Tj
6.2268 0 Td
(of)Tj
1.0678 0 Td
(patient)Tj
3.1937 0 Td
(population)Tj
4.8284 0 Td
(with)Tj
-28.2947 -1.167 Td
(Crohn's)Tj
3.5386 0 Td
(disease)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 558.4251 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(428)Tj
1.644 0 Td
(CD)Tj
1.6214 0 Td
(patients)Tj
3.3676 0 Td
(diagnosed)Tj
4.2803 0 Td
(between)Tj
3.5319 0 Td
(January)Tj
3.3165 0 Td
(2007)Tj
2.126 0 Td
(and)Tj
1.7291 0 Td
(April)Tj
2.3074 0 Td
(2015)Tj
2.1203 0 Td
(were)Tj
2.1203 0 Td
(included)Tj
3.7134 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(study.)Tj
-34.384 -1.2982 Td
(Male/female)Tj
5.1816 0 Td
(proportion)Tj
4.6318 0 Td
(was)Tj
1.6951 0 Td
(194/234.)Tj
3.6284 0 Td
(Mean)Tj
2.5228 0 Td
(age)Tj
1.542 0 Td
(at)Tj
0.9525 0 Td
(onset)Tj
2.3584 0 Td
(of)Tj
1.0148 0 Td
(symptoms)Tj
4.3596 0 Td
(and)Tj
1.7291 0 Td
(at)Tj
0.9525 0 Td
(diagnosis)Tj
3.9571 0 Td
(was)Tj
-34.5257 -1.2983 Td
(26.6)Tj
/F12 1 Tf
[()]TJ
/F5 1 Tf
(11.3)Tj
4.0932 0 Td
(and)Tj
1.7291 0 Td
(27.9)Tj
/F12 1 Tf
[()]TJ
/F5 1 Tf
(11.4)Tj
4.0932 0 Td
(years.)Tj
2.4888 0 Td
(At)Tj
1.2075 0 Td
(diagnosis,)Tj
4.1839 0 Td
(ileocolonic)Tj
4.5865 0 Td
(and)Tj
1.7291 0 Td
(colonic)Tj
3.1408 0 Td
(locations)Tj
3.8154 0 Td
(and)Tj
1.7291 0 Td
(non-stric-)Tj
-32.7966 -1.3039 Td
(turing,)Tj
2.9196 0 Td
(non-penetrating)Tj
6.7748 0 Td
(behaviour)Tj
4.2406 0 Td
(were)Tj
2.1203 0 Td
(the)Tj
1.4683 0 Td
(most)Tj
2.2054 0 Td
(common)Tj
3.8494 0 Td
(\(35.3%,)Tj
3.1918 0 Td
(34.6%)Tj
2.6305 0 Td
(and)Tj
1.7291 0 Td
(44.4%\))Tj
2.9707 0 Td
(disease)Tj
-34.1005 -1.2983 Td
(phenotypes.)Tj
5.0229 0 Td
(Positive)Tj
3.3562 0 Td
(family)Tj
2.7326 0 Td
(history)Tj
3.0047 0 Td
(of)Tj
1.0148 0 Td
(IBD)Tj
1.8765 0 Td
(was)Tj
1.7008 0 Td
(reviewed)Tj
3.7927 0 Td
(in)Tj
1.0375 0 Td
(8.8%)Tj
2.1543 0 Td
(of)Tj
1.0148 0 Td
(CD)Tj
1.6214 0 Td
(patients.)Tj
3.5887 0 Td
(Considering)Tj
-31.9179 -1.2982 Td
(extraintestinal)Tj
5.9016 0 Td
(manifestations,)Tj
6.3043 0 Td
(arthralgia)Tj
4.0705 0 Td
(and)Tj
1.7291 0 Td
(arthritis)Tj
3.4129 0 Td
(occurred)Tj
3.7984 0 Td
(in)Tj
1.0375 0 Td
(54%)Tj
1.9275 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(patients.)Tj
3.5943 0 Td
(The)Tj
-34.2593 -1.3039 Td
(most)Tj
2.2053 0 Td
(common)Tj
3.8437 0 Td
(joints)Tj
2.4605 0 Td
(involved)Tj
3.651 0 Td
(were)Tj
2.1203 0 Td
(knee,)Tj
2.3357 0 Td
(shoulder,)Tj
3.9402 0 Td
(hand,)Tj
2.4831 0 Td
(spine)Tj
2.3357 0 Td
(and)Tj
1.7292 0 Td
(hip.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 451.9559 cm
BT
/F10 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Demographic)Tj
5.9291 0 Td
(data)Tj
2.0363 0 Td
(and)Tj
1.7905 0 Td
(clinical)Tj
3.2221 0 Td
(characteristics)Tj
6.2268 0 Td
(of)Tj
1.0678 0 Td
(ulcerative)Tj
4.2992 0 Td
(colitis)Tj
2.7355 0 Td
(patient)Tj
-27.3073 -1.1669 Td
(population)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 420.9448 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Data)Tj
2.1203 0 Td
(of)Tj
1.0147 0 Td
(483)Tj
1.6498 0 Td
(UC)Tj
1.6157 0 Td
(patients)Tj
3.3676 0 Td
(were)Tj
2.1259 0 Td
(analyzed)Tj
3.7021 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(study.)Tj
2.6135 0 Td
(Male/female)Tj
5.1817 0 Td
(proportion)Tj
4.6318 0 Td
(was)Tj
1.7008 0 Td
(228/255.)Tj
-32.2297 -1.2982 Td
(Mean)Tj
2.5171 0 Td
(age)Tj
1.542 0 Td
(at)Tj
0.9525 0 Td
(onset)Tj
2.3584 0 Td
(of)Tj
1.0148 0 Td
(symptoms)Tj
4.3596 0 Td
(and)Tj
1.7292 0 Td
(at)Tj
0.9524 0 Td
(diagnosis)Tj
3.9571 0 Td
(was)Tj
1.7008 0 Td
(30.3)Tj
/F12 1 Tf
[()]TJ
/F5 1 Tf
(12.4)Tj
4.0932 0 Td
(and)Tj
1.7291 0 Td
(30.9)Tj
/F12 1 Tf
[()]TJ
/F5 1 Tf
(12.5)Tj
4.0932 0 Td
(years.)Tj
2.4945 0 Td
(Proctitis)Tj
-33.4939 -1.2983 Td
(and)Tj
1.7291 0 Td
(left-sided)Tj
3.9344 0 Td
(colitis)Tj
2.5909 0 Td
(were)Tj
2.1203 0 Td
(the)Tj
1.4683 0 Td
(most)Tj
2.2054 0 Td
(frequent)Tj
3.6113 0 Td
(disease)Tj
3.016 0 Td
(extents)Tj
3.0387 0 Td
(\(34.2%)Tj
2.9707 0 Td
(and)Tj
1.7292 0 Td
(34.6%\).)Tj
3.1974 0 Td
(At)Tj
1.2019 0 Td
(the)Tj
1.4683 0 Td
(time)Tj
2.0296 0 Td
(of)Tj
-36.3115 -1.3039 Td
(the)Tj
1.4683 0 Td
(first)Tj
1.8085 0 Td
(appointment,)Tj
5.6239 0 Td
(registered)Tj
4.1499 0 Td
(disease)Tj
3.016 0 Td
(activity)Tj
3.1181 0 Td
(was)Tj
1.7008 0 Td
(mild)Tj
2.0806 0 Td
(in)Tj
1.0375 0 Td
(41.6%,)Tj
2.8516 0 Td
(moderate)Tj
4.0252 0 Td
(in)Tj
1.0375 0 Td
(41.6%,)Tj
2.8573 0 Td
(and)Tj
-34.7752 -1.2983 Td
(severe)Tj
2.6758 0 Td
(in)Tj
1.0375 0 Td
(12.2%)Tj
2.6305 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(UC)Tj
1.6157 0 Td
(patients.)Tj
3.5943 0 Td
(The)Tj
1.7858 0 Td
(remaining)Tj
4.3654 0 Td
(4.6%)Tj
2.1543 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(patients)Tj
3.3676 0 Td
(was)Tj
1.7007 0 Td
(documented)Tj
5.2441 0 Td
(to)Tj
-35.138 -1.2982 Td
(have)Tj
2.0579 0 Td
(inactive)Tj
3.3392 0 Td
(disease)Tj
3.016 0 Td
(at)Tj
0.9525 0 Td
(the)Tj
1.4683 0 Td
(time)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(first)Tj
1.8085 0 Td
(appointment.)Tj
5.6239 0 Td
(Positive)Tj
3.3562 0 Td
(family)Tj
2.7269 0 Td
(history)Tj
3.0104 0 Td
(of)Tj
1.0148 0 Td
(IBD)Tj
1.8765 0 Td
(was)Tj
1.7008 0 Td
(regis-)Tj
-34.9963 -1.3039 Td
(tered)Tj
2.262 0 Td
(in)Tj
1.0375 0 Td
(11.3%)Tj
2.6305 0 Td
(of)Tj
1.0148 0 Td
(UC)Tj
1.6157 0 Td
(patients.)Tj
3.5943 0 Td
(Arthralgia)Tj
4.32 0 Td
(and)Tj
1.7291 0 Td
(arthritis)Tj
3.4186 0 Td
(were)Tj
2.1203 0 Td
(present)Tj
3.1634 0 Td
(in)Tj
1.0375 0 Td
(57.8%)Tj
2.6305 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(patients.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 314.4755 cm
BT
/F10 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Proportions)Tj
5.2913 0 Td
(of)Tj
1.0678 0 Td
(biological)Tj
4.285 0 Td
(therapy)Tj
3.4253 0 Td
(and/or)Tj
3.033 0 Td
(surgery)Tj
3.3355 0 Td
(in)Tj
1.0677 0 Td
(CD)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 297.4677 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(60.5%)Tj
2.6305 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(CD)Tj
1.6158 0 Td
(patients)Tj
3.3732 0 Td
(received)Tj
3.5319 0 Td
(thiopurine,)Tj
4.6998 0 Td
(23.6%)Tj
2.6306 0 Td
(methylprednisolone,)Tj
8.4642 0 Td
(45.6%)Tj
2.6305 0 Td
(biological)Tj
-32.0596 -1.2982 Td
(therapy)Tj
3.2484 0 Td
(and)Tj
1.7292 0 Td
(28%)Tj
1.9275 0 Td
(combined)Tj
4.2406 0 Td
(thiopurine)Tj
4.4787 0 Td
(and)Tj
1.7291 0 Td
(biological)Tj
4.0932 0 Td
(therapy.)Tj
3.4696 0 Td
(In)Tj
1.1112 0 Td
(CD,)Tj
1.8425 0 Td
(use)Tj
1.5307 0 Td
(of)Tj
1.0148 0 Td
(thiopurine)Tj
4.4787 0 Td
(was)Tj
-34.8942 -1.2983 Td
(more)Tj
2.3414 0 Td
(common)Tj
3.8437 0 Td
(in)Tj
1.0375 0 Td
(patients)Tj
3.3675 0 Td
(with)Tj
1.9956 0 Td
(colonic)Tj
3.1408 0 Td
(and)Tj
1.7348 0 Td
(ileocolonic)Tj
4.5864 0 Td
(locations)Tj
3.8097 0 Td
(vs.)Tj
1.2643 0 Td
(ileal)Tj
1.8368 0 Td
(location)Tj
3.4469 0 Td
(\(34.3%)Tj
2.9707 0 Td
(and)Tj
-35.3761 -1.3039 Td
(37.7%)Tj
2.6305 0 Td
(vs.)Tj
1.2586 0 Td
(27.9%,)Tj
2.8573 0 Td
(p)Tj
0.737 0 Td
(=)Tj
0.7993 0 Td
(0.03\).)Tj
2.4378 0 Td
(Need)Tj
2.3301 0 Td
(of)Tj
1.0148 0 Td
(biological)Tj
4.0875 0 Td
(therapy)Tj
3.2485 0 Td
(was)Tj
1.7008 0 Td
(not)Tj
1.5704 0 Td
(in)Tj
1.0374 0 Td
(association)Tj
4.6261 0 Td
(with)Tj
2.0013 0 Td
(any)Tj
1.6554 0 Td
(location)Tj
-33.9928 -1.2983 Td
(or)Tj
1.0941 0 Td
(behaviour)Tj
4.2406 0 Td
(of)Tj
1.0148 0 Td
(CD)Tj
1.6214 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(presence)Tj
3.7133 0 Td
(of)Tj
1.0148 0 Td
(extraintestinal)Tj
5.9074 0 Td
(manifestations.)Tj
-20.6077 -1.2982 Td
(Surgery)Tj
3.3108 0 Td
(was)Tj
1.7008 0 Td
(needed)Tj
3.0954 0 Td
(in)Tj
1.0318 0 Td
(228)Tj
1.6498 0 Td
(patients)Tj
3.3675 0 Td
(\(number)Tj
3.7587 0 Td
(of)Tj
1.0148 0 Td
(surgical)Tj
3.3165 0 Td
(interventions)Tj
5.5389 0 Td
(\(both)Tj
2.3981 0 Td
(abdominal)Tj
4.5127 0 Td
(and)Tj
-35.892 -1.3039 Td
(perianal\):)Tj
4.0251 0 Td
(440\).)Tj
2.211 0 Td
(Bowel)Tj
2.6646 0 Td
(resection)Tj
3.8437 0 Td
(and)Tj
1.7292 0 Td
(perianal)Tj
3.4639 0 Td
(surgery)Tj
3.1918 0 Td
(was)Tj
1.7007 0 Td
(performed)Tj
4.4674 0 Td
(in)Tj
1.0375 0 Td
(66%)Tj
1.9275 0 Td
(and)Tj
1.7292 0 Td
(34%)Tj
1.9275 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-34.9339 -1.2983 Td
(cases.)Tj
2.4491 0 Td
(Surgery)Tj
3.3051 0 Td
(proved)Tj
3.0218 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(more)Tj
2.3414 0 Td
(common)Tj
3.8437 0 Td
(in)Tj
1.0375 0 Td
(patients)Tj
3.3675 0 Td
(with)Tj
1.9956 0 Td
(ileal)Tj
1.8425 0 Td
(location)Tj
3.4469 0 Td
(compared)Tj
4.2463 0 Td
(to)Tj
1.0261 0 Td
(colonic)Tj
-34.1005 -1.2983 Td
(and)Tj
1.7291 0 Td
(ileocolonic)Tj
4.5864 0 Td
(locations)Tj
3.8097 0 Td
(\(p)Tj
1.0772 0 Td
(=)Tj
0.805 0 Td
(0.06\))Tj
2.211 0 Td
(and)Tj
1.7292 0 Td
(with)Tj
1.9955 0 Td
(penetrating)Tj
4.8189 0 Td
(behaviour)Tj
4.2406 0 Td
(compared)Tj
4.2406 0 Td
(to)Tj
1.0262 0 Td
(non-strictur-)Tj
-32.2694 -1.3039 Td
(ing,)Tj
1.7234 0 Td
(non-penetrating)Tj
6.7748 0 Td
(and)Tj
1.7291 0 Td
(stricturing)Tj
4.4163 0 Td
(behaviour)Tj
4.2406 0 Td
(\(p)Tj
/F13 1 Tf
0 Tc
()Tj
/F5 1 Tf
-0.004 Tc
(0.001\).)Tj
4.5411 0 Td
(Higher)Tj
3.0444 0 Td
(proportion)Tj
4.6318 0 Td
(\(58.2%\))Tj
3.3108 0 Td
(of)Tj
1.0148 0 Td
(sur-)Tj
-35.4271 -1.2983 Td
(gery)Tj
1.9332 0 Td
(was)Tj
1.7007 0 Td
(shown)Tj
2.846 0 Td
(in)Tj
1.0375 0 Td
(patient)Tj
3.0047 0 Td
(aged)Tj
2.0693 0 Td
(above)Tj
2.5511 0 Td
(40)Tj
1.1679 0 Td
(years)Tj
2.2677 0 Td
(\(p)Tj
1.0772 0 Td
(=)Tj
0.7993 0 Td
(0.051\).)Tj
2.914 0 Td
(In)Tj
1.1055 0 Td
(CD,)Tj
1.8482 0 Td
(neither)Tj
3.0784 0 Td
(baseline)Tj
3.4299 0 Td
(CDAI)Tj
2.6419 0 Td
(or)Tj
-35.4725 -1.2982 Td
(CRP)Tj
2.0636 0 Td
(were)Tj
2.1203 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9955 0 Td
(the)Tj
1.4741 0 Td
(need)Tj
2.1429 0 Td
(of)Tj
1.0148 0 Td
(biological)Tj
4.0876 0 Td
(therapy)Tj
3.2484 0 Td
(and/or)Tj
2.9367 0 Td
(surgery.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 125.9716 cm
BT
/F10 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Proportions)Tj
5.2913 0 Td
(of)Tj
1.0678 0 Td
(biological)Tj
4.285 0 Td
(therapy)Tj
3.4253 0 Td
(and/or)Tj
3.033 0 Td
(surgery)Tj
3.3355 0 Td
(in)Tj
1.0677 0 Td
(UC)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 109.0204 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(43.5%)Tj
2.6305 0 Td
(of)Tj
1.0148 0 Td
(UC)Tj
1.6157 0 Td
(patients)Tj
3.3676 0 Td
(were)Tj
2.1259 0 Td
(on)Tj
1.2756 0 Td
(thiopurine,)Tj
4.6998 0 Td
(34.2%)Tj
2.6306 0 Td
(on)Tj
1.2755 0 Td
(methylprednisolone,)Tj
8.4642 0 Td
(26.3%)Tj
2.6306 0 Td
(on)Tj
1.2756 0 Td
(biological)Tj
-33.0064 -1.3039 Td
(therapy)Tj
3.2484 0 Td
(and)Tj
1.7292 0 Td
(14.8%)Tj
2.6305 0 Td
(on)Tj
1.2699 0 Td
(combined)Tj
4.2463 0 Td
(thiopurine)Tj
4.4787 0 Td
(and)Tj
1.7291 0 Td
(biological)Tj
4.0875 0 Td
(therapy)Tj
3.2485 0 Td
(during)Tj
2.9254 0 Td
(the)Tj
1.474 0 Td
(whole)Tj
2.6078 0 Td
(period.)Tj
-33.6753 -1.2982 Td
(Use)Tj
1.7404 0 Td
(of)Tj
1.0148 0 Td
(thiopurines)Tj
4.8359 0 Td
(and)Tj
1.7291 0 Td
(biologicals)Tj
4.4504 0 Td
(did)Tj
1.542 0 Td
(not)Tj
1.5761 0 Td
(show)Tj
2.3017 0 Td
(any)Tj
1.6554 0 Td
(association)Tj
4.6261 0 Td
(with)Tj
2.0013 0 Td
(disease)Tj
3.016 0 Td
(extent.)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 417.3165 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Disease)Tj
3.7701 0 Td
(outcome)Tj
3.9968 0 Td
(in)Tj
0.978 0 Td
(IBD)Tj
1.8638 0 Td
(in)Tj
0.978 0 Td
(a)Tj
0.7653 0 Td
(Hungarian)Tj
4.7481 0 Td
(center)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.02008)Tj
4.089 0 Td
(24)Tj
0 g
2.0906 0 Td
(July)Tj
1.9701 0 Td
(30,)Tj
1.5874 0 Td
(2018)Tj
35.894 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
BT
66.9477 0 Td
(8)Tj
ET
Q
endstream
endobj
49 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 50 0 R/Contents 51 0 R/TrimBox[0 0 612 792]>>
endobj
50 0 obj
[52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R]
endobj
52 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.t001)>>
endobj
53 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.t002)>>
endobj
54 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.s001)>>
endobj
55 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.t001)>>
endobj
56 0 obj
<>/Border[0 0 0]/A 58 0 R>>
endobj
58 0 obj
<>
endobj
57 0 obj
<>/Border[0 0 0]/A 59 0 R>>
endobj
59 0 obj
<>
endobj
51 0 obj
[60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R]
endobj
60 0 obj
<>stream
q
0.83 0.64 0.02 0 k
265.7764 503.7732 m
294.9732 503.7732 l
h
f*
429.3921 399.7417 m
458.6457 399.7417 l
h
f*
464.2016 399.7417 m
498.1039 399.7417 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 211.9748 707.4141 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Colectomy)Tj
4.5637 0 Td
(was)Tj
1.7008 0 Td
(performed)Tj
4.4674 0 Td
(in)Tj
1.0374 0 Td
(77)Tj
1.1736 0 Td
(patients)Tj
3.3675 0 Td
(throughout)Tj
4.7792 0 Td
(the)Tj
1.4683 0 Td
(follow-up)Tj
4.0932 0 Td
(period.)Tj
3.0614 0 Td
(51%)Tj
1.9276 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-33.8511 -1.3039 Td
(patients)Tj
3.3618 0 Td
(underwent)Tj
4.5638 0 Td
(laparoscopic)Tj
5.2213 0 Td
(surgery.)Tj
3.4129 0 Td
(One-,)Tj
2.5058 0 Td
(two,-and)Tj
3.7928 0 Td
(three-stage)Tj
4.5864 0 Td
(surgeries)Tj
3.7871 0 Td
(were)Tj
2.1146 0 Td
(performed)Tj
-33.3465 -1.2982 Td
(in)Tj
1.0318 0 Td
(13.3%,)Tj
2.8572 0 Td
(40%)Tj
1.9276 0 Td
(and)Tj
1.7291 0 Td
(46.7%)Tj
2.6306 0 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(operated)Tj
3.7247 0 Td
(patients.)Tj
3.5943 0 Td
(Significantly)Tj
5.2044 0 Td
(higher)Tj
2.8006 0 Td
(proportion)Tj
4.6318 0 Td
(\(75.3%\))Tj
3.3108 0 Td
(of)Tj
-35.926 -1.2983 Td
(surgery)Tj
3.1917 0 Td
(was)Tj
1.7008 0 Td
(in)Tj
1.0375 0 Td
(patient)Tj
3.0047 0 Td
(aged)Tj
2.0693 0 Td
(above)Tj
2.5455 0 Td
(40)Tj
1.1735 0 Td
(years)Tj
2.262 0 Td
(\(p)Tj
1.0772 0 Td
(=)Tj
0.805 0 Td
(0.035\).)Tj
2.9083 0 Td
(Disease)Tj
3.2259 0 Td
(extent)Tj
2.6815 0 Td
(did)Tj
1.542 0 Td
(not)Tj
1.5704 0 Td
(show)Tj
2.3018 0 Td
(any)Tj
1.6554 0 Td
(associ-)Tj
-34.7525 -1.2983 Td
(ation)Tj
2.2733 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.474 0 Td
(need)Tj
2.143 0 Td
(of)Tj
1.0148 0 Td
(surgery.)Tj
3.4185 0 Td
(Rate)Tj
1.9956 0 Td
(of)Tj
1.0148 0 Td
(surgery)Tj
3.1975 0 Td
(did)Tj
1.542 0 Td
(not)Tj
1.5761 0 Td
(differ)Tj
2.381 0 Td
(significantly)Tj
5.091 0 Td
(in)Tj
1.0375 0 Td
(patients)Tj
3.3675 0 Td
(receiving)Tj
-33.5222 -1.3039 Td
(biologicals,)Tj
4.6771 0 Td
(however)Tj
3.6113 0 Td
(it)Tj
0.7823 0 Td
(was)Tj
1.7008 0 Td
(lower)Tj
2.4491 0 Td
(in)Tj
1.0375 0 Td
(patients)Tj
3.3676 0 Td
(treated)Tj
2.999 0 Td
(with)Tj
1.9956 0 Td
(thiopurines)Tj
4.8358 0 Td
(\(p)Tj
1.0772 0 Td
(=)Tj
0.7994 0 Td
(0.045\).)Tj
2.914 0 Td
(Need)Tj
2.33 0 Td
(of)Tj
1.0148 0 Td
(bio-)Tj
-35.5915 -1.2982 Td
(logical)Tj
2.8062 0 Td
(therapy)Tj
3.2485 0 Td
(and)Tj
1.7291 0 Td
(need)Tj
2.143 0 Td
(of)Tj
1.0148 0 Td
(biological)Tj
4.0932 0 Td
(therapy)Tj
3.2428 0 Td
(and)Tj
1.7348 0 Td
(surgery)Tj
3.1918 0 Td
(together)Tj
3.5376 0 Td
(were)Tj
2.1203 0 Td
(more)Tj
2.3414 0 Td
(common)Tj
3.8438 0 Td
(in)Tj
-35.0473 -1.2983 Td
(patients)Tj
3.3675 0 Td
(with)Tj
1.9956 0 Td
(more)Tj
2.3414 0 Td
(severe)Tj
2.6758 0 Td
(disease)Tj
3.0218 0 Td
(activity)Tj
3.118 0 Td
(determined)Tj
4.8473 0 Td
(by)Tj
1.1848 0 Td
(pMayo)Tj
3.0274 0 Td
(score)Tj
2.3017 0 Td
(and)Tj
1.7292 0 Td
(CRP)Tj
2.0692 0 Td
(level)Tj
2.0126 0 Td
(at)Tj
0.9525 0 Td
(the)Tj
-34.6448 -1.3039 Td
(first)Tj
1.8028 0 Td
(attendance)Tj
4.5807 0 Td
(\(p)Tj
/F13 1 Tf
0 Tc
()Tj
/F5 1 Tf
-0.004 Tc
(0.001\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 574.8094 cm
BT
/F10 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Comparison)Tj
5.4094 0 Td
(of)Tj
1.0678 0 Td
(the)Tj
1.5401 0 Td
(demographic)Tj
5.7213 0 Td
(and)Tj
1.7906 0 Td
(clinical)Tj
3.2221 0 Td
(parameters)Tj
4.9323 0 Td
(of)Tj
1.0677 0 Td
(CD)Tj
1.6489 0 Td
(and)Tj
1.7952 0 Td
(UC)Tj
-28.1954 -1.1669 Td
(patients)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 543.7984 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(median)Tj
3.2428 0 Td
(follow-up)Tj
4.0932 0 Td
(time)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(patients)Tj
3.3676 0 Td
(was)Tj
1.7008 0 Td
(3.6)Tj
1.3946 0 Td
(years.)Tj
2.4888 0 Td
(Ratio)Tj
2.3471 0 Td
(of)Tj
1.0148 0 Td
(males/females)Tj
5.8336 0 Td
(did)Tj
1.5421 0 Td
(not)Tj
1.5703 0 Td
(differ)Tj
-34.8885 -1.2982 Td
(significantly)Tj
5.0853 0 Td
(among)Tj
2.999 0 Td
(the)Tj
1.4683 0 Td
(two)Tj
1.7065 0 Td
(disease)Tj
3.0217 0 Td
(groups)Tj
2.965 0 Td
(\(p)Tj
1.0772 0 Td
(=)Tj
0.805 0 Td
(0.435\).)Tj
2.9083 0 Td
(The)Tj
1.7859 0 Td
(median)Tj
3.2371 0 Td
(lag)Tj
1.3663 0 Td
(time)Tj
2.0296 0 Td
(between)Tj
3.5319 0 Td
(onset)Tj
2.3528 0 Td
(of)Tj
-36.3399 -1.2983 Td
(symptoms)Tj
4.3596 0 Td
(and)Tj
1.7291 0 Td
(diagnosis)Tj
3.9572 0 Td
(proved)Tj
3.0217 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(significantly)Tj
5.0853 0 Td
(longer)Tj
2.7836 0 Td
(in)Tj
1.0375 0 Td
(UC)Tj
1.6157 0 Td
(than)Tj
2.0296 0 Td
(in)Tj
1.0375 0 Td
(CD)Tj
1.6214 0 Td
(\(4.6)Tj
1.7348 0 Td
(years)Tj
2.262 0 Td
(vs.)Tj
1.2643 0 Td
(2.1)Tj
-35.7163 -1.2982 Td
(years,)Tj
2.4888 0 Td
(p)Tj
0.737 0 Td
(=)Tj
0.7993 0 Td
(0.01\))Tj
2.211 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7836 0 Td
(1)Tj
0 g
(\).)Tj
1.2586 0 Td
(However,)Tj
4.0819 0 Td
(after)Tj
2.0352 0 Td
(excluding)Tj
4.1102 0 Td
(cases)Tj
2.2224 0 Td
(where)Tj
2.6532 0 Td
(we)Tj
1.3266 0 Td
(were)Tj
2.126 0 Td
(not)Tj
1.5704 0 Td
(able)Tj
1.8311 0 Td
(to)Tj
1.0262 0 Td
(perform)Tj
3.5149 0 Td
(a)Tj
-36.7764 -1.304 Td
(complete)Tj
3.8777 0 Td
(follow-up)Tj
4.0932 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(medical)Tj
3.3618 0 Td
(records,)Tj
3.4299 0 Td
(no)Tj
1.2756 0 Td
(significant)Tj
4.388 0 Td
(difference)Tj
4.2066 0 Td
(remained)Tj
4.0365 0 Td
(regarding)Tj
4.0932 0 Td
(the)Tj
-35.2457 -1.2982 Td
(median)Tj
3.2371 0 Td
(lag)Tj
1.3663 0 Td
(time)Tj
2.0296 0 Td
(between)Tj
3.5263 0 Td
(onset)Tj
2.3584 0 Td
(of)Tj
1.0148 0 Td
(symptoms)Tj
4.3596 0 Td
(and)Tj
1.7291 0 Td
(diagnosis.)Tj
-18.425 -1.2983 Td
(Smoking)Tj
3.804 0 Td
(and)Tj
1.7292 0 Td
(history)Tj
3.0047 0 Td
(of)Tj
1.0148 0 Td
(appendectomy)Tj
6.1171 0 Td
(were)Tj
2.1203 0 Td
(significantly)Tj
5.091 0 Td
(more)Tj
2.3414 0 Td
(common)Tj
3.8437 0 Td
(in)Tj
1.0375 0 Td
(CD)Tj
1.6214 0 Td
(vs.)Tj
1.2586 0 Td
(UC)Tj
-34.1799 -1.3039 Td
(patients)Tj
3.3675 0 Td
(\(p)Tj
/F13 1 Tf
0 Tc
()Tj
/F5 1 Tf
-0.004 Tc
(0.001)Tj
3.9741 0 Td
(and)Tj
1.7348 0 Td
(p)Tj
0.737 0 Td
(=)Tj
0.7994 0 Td
(0.003\).)Tj
2.914 0 Td
(No)Tj
1.4627 0 Td
(difference)Tj
4.2009 0 Td
(was)Tj
1.7008 0 Td
(shown)Tj
2.8459 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(use)Tj
1.5364 0 Td
(of)Tj
1.0148 0 Td
(oral)Tj
1.7745 0 Td
(contraceptives)Tj
-30.5686 -1.2983 Td
(between)Tj
3.5262 0 Td
(the)Tj
1.4684 0 Td
(two)Tj
1.7121 0 Td
(patient)Tj
3.0047 0 Td
(groups.)Tj
3.1974 0 Td
(No)Tj
1.4627 0 Td
(association)Tj
4.6261 0 Td
(was)Tj
1.7008 0 Td
(found)Tj
2.6192 0 Td
(between)Tj
3.5263 0 Td
(either)Tj
2.5341 0 Td
(positive)Tj
3.3165 0 Td
(family)Tj
2.727 0 Td
(his-)Tj
-35.4215 -1.2982 Td
(tory)Tj
1.8481 0 Td
(of)Tj
1.0148 0 Td
(IBD,)Tj
2.1033 0 Td
(or)Tj
1.0999 0 Td
(any)Tj
1.6554 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(accompanying)Tj
6.0661 0 Td
(extraintestinal)Tj
5.9017 0 Td
(manifestations)Tj
6.0775 0 Td
(and)Tj
1.7291 0 Td
(any)Tj
1.6611 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(disease)Tj
-34.1232 -1.304 Td
(locations/extents)Tj
6.9618 0 Td
(or)Tj
1.0942 0 Td
(complicated)Tj
5.108 0 Td
(disease)Tj
3.016 0 Td
(behaviours)Tj
4.6034 0 Td
(in)Tj
1.0375 0 Td
(CD.)Tj
1.8425 0 Td
(Detailed)Tj
3.5773 0 Td
(demographic)Tj
5.5049 0 Td
(and)Tj
1.7291 0 Td
(clinical)Tj
-34.4747 -1.2982 Td
(characteristics)Tj
5.9016 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(enrolled)Tj
3.5093 0 Td
(patients)Tj
3.3732 0 Td
(are)Tj
1.4457 0 Td
(summarized)Tj
5.1874 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0318 0 Td
(Table)Tj
2.4434 0 Td
(2)Tj
0 g
0.6973 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(S1)Tj
1.508 0 Td
(Table)Tj
0 g
(\).)Tj
-26.3903 -1.2983 Td
(Ratio)Tj
2.3527 0 Td
(of)Tj
1.0148 0 Td
(males/females)Tj
5.828 0 Td
(did)Tj
1.542 0 Td
(not)Tj
1.5761 0 Td
(differ)Tj
2.3811 0 Td
(regarding)Tj
4.0988 0 Td
(the)Tj
1.4684 0 Td
(use)Tj
1.5307 0 Td
(of)Tj
1.0148 0 Td
(thiopurines)Tj
4.8359 0 Td
(and/or)Tj
2.9366 0 Td
(biological)Tj
-31.7761 -1.2982 Td
(therapy.)Tj
3.4695 0 Td
(Rate)Tj
2.0013 0 Td
(of)Tj
1.0148 0 Td
(surgery)Tj
3.1918 0 Td
(proved)Tj
3.0217 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(significantly)Tj
5.091 0 Td
(higher)Tj
2.8006 0 Td
(in)Tj
1.0375 0 Td
(CD)Tj
1.6157 0 Td
(vs.)Tj
1.2642 0 Td
(UC)Tj
1.6158 0 Td
(\(p)Tj
/F13 1 Tf
0 Tc
()Tj
/F5 1 Tf
-0.004 Tc
(0.001\).)Tj
4.5467 0 Td
(No)Tj
1.4627 0 Td
(rela-)Tj
-34.3103 -1.304 Td
(tionship)Tj
3.5149 0 Td
(was)Tj
1.6951 0 Td
(found)Tj
2.6192 0 Td
(between)Tj
3.5319 0 Td
(smoking,)Tj
3.9062 0 Td
(appendectomy,)Tj
6.3439 0 Td
(positive)Tj
3.3165 0 Td
(family)Tj
2.7269 0 Td
(history)Tj
3.0104 0 Td
(of)Tj
1.0148 0 Td
(IBD)Tj
1.8765 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
-35.2854 -1.2982 Td
(presence)Tj
3.7133 0 Td
(of)Tj
1.0148 0 Td
(extraintestinal)Tj
5.9017 0 Td
(manifestations)Tj
6.0774 0 Td
(and)Tj
1.7292 0 Td
(the)Tj
1.4683 0 Td
(need)Tj
2.143 0 Td
(of)Tj
1.0148 0 Td
(surgery)Tj
3.1974 0 Td
(or)Tj
1.0999 0 Td
(biological)Tj
4.0875 0 Td
(therapy.)Tj
3.4753 0 Td
(Use)Tj
1.7404 0 Td
(of)Tj
-36.663 -1.2983 Td
(oral)Tj
1.7744 0 Td
(contraceptives)Tj
5.9754 0 Td
(was)Tj
1.6951 0 Td
(protective)Tj
4.2066 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(need)Tj
2.143 0 Td
(of)Tj
1.0148 0 Td
(surgery)Tj
3.1975 0 Td
(and)Tj
1.7291 0 Td
(biologicals)Tj
4.4504 0 Td
(in)Tj
1.0374 0 Td
(both)Tj
2.058 0 Td
(diseases.)Tj
-32.0256 -1.3039 Td
(Rates)Tj
2.3584 0 Td
(of)Tj
1.0148 0 Td
(surgery)Tj
3.1917 0 Td
(and)Tj
1.7348 0 Td
(biological)Tj
4.0876 0 Td
(therapy)Tj
3.2485 0 Td
(together)Tj
3.5319 0 Td
(were)Tj
2.126 0 Td
(significantly)Tj
5.0853 0 Td
(more)Tj
2.3414 0 Td
(common)Tj
3.8494 0 Td
(in)Tj
1.0318 0 Td
(patients)Tj
-33.6016 -1.2983 Td
(diagnosed)Tj
4.2802 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
2.0296 0 Td
(1)Tj
0.6974 0 Td
(year)Tj
1.8992 0 Td
(after)Tj
2.0352 0 Td
(the)Tj
1.474 0 Td
(onset)Tj
2.3528 0 Td
(of)Tj
1.0148 0 Td
(symptoms)Tj
4.3596 0 Td
(in)Tj
1.0375 0 Td
(CD)Tj
1.6214 0 Td
(and)Tj
1.7291 0 Td
(UC)Tj
1.6214 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8199 0 Td
(\(p)Tj
1.0771 0 Td
(=)Tj
0.7994 0 Td
(0.012)Tj
2.3471 0 Td
(and)Tj
-35.5519 -1.2982 Td
(p)Tj
0.737 0 Td
(=)Tj
0.7993 0 Td
(0.002\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 268.2708 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Discussion)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 251.2629 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(present)Tj
3.1634 0 Td
(study)Tj
2.3925 0 Td
(in)Tj
1.0318 0 Td
(which)Tj
2.6532 0 Td
(CD)Tj
1.6214 0 Td
(and)Tj
1.7291 0 Td
(UC)Tj
1.6158 0 Td
(patients)Tj
3.3732 0 Td
(were)Tj
2.1203 0 Td
(followed)Tj
3.651 0 Td
(up)Tj
1.2642 0 Td
(for)Tj
1.3833 0 Td
(a)Tj
0.6576 0 Td
(median)Tj
3.2372 0 Td
(of)Tj
1.0148 0 Td
(3.6)Tj
1.4003 0 Td
(years)Tj
-34.0892 -1.2982 Td
(has)Tj
1.542 0 Td
(resulted)Tj
3.3959 0 Td
(in)Tj
1.0374 0 Td
(several)Tj
2.9367 0 Td
(important)Tj
4.2803 0 Td
(findings.)Tj
3.719 0 Td
(Considering)Tj
5.1704 0 Td
(the)Tj
1.4683 0 Td
(whole)Tj
2.6079 0 Td
(study)Tj
2.3924 0 Td
(population,)Tj
4.8132 0 Td
(median)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
36 210.1414 m
576 210.1414 l
576 209.6413 l
36 209.6413 l
f*
575.9991 197.1414 m
36 197.1414 l
36 197.6414 l
575.9991 197.6414 l
f*
119.2045 197.1414 m
119.2045 184.6414 l
118.7045 184.6414 l
118.7045 197.1414 l
f*
118.7045 184.6414 m
36 184.6414 l
36 185.1415 l
118.7045 185.1415 l
f*
231.4346 197.1414 m
231.4346 184.6414 l
230.9346 184.6414 l
230.9346 197.1414 l
f*
230.9346 184.6414 m
119.2045 184.6414 l
119.2045 185.1415 l
230.9346 185.1415 l
f*
321.2935 197.1414 m
321.2935 184.6414 l
320.7934 184.6414 l
320.7934 197.1414 l
f*
320.7934 184.6414 m
231.4346 184.6414 l
231.4346 185.1415 l
320.7934 185.1415 l
f*
404.5068 197.1414 m
404.5068 184.6414 l
404.0067 184.6414 l
404.0067 197.1414 l
f*
404.0067 184.6414 m
321.2935 184.6414 l
321.2935 185.1415 l
404.0067 185.1415 l
f*
487.7201 197.1414 m
487.7201 184.6414 l
487.22 184.6414 l
487.22 197.1414 l
f*
487.22 184.6414 m
404.5068 184.6414 l
404.5068 185.1415 l
487.22 185.1415 l
f*
575.9991 184.6414 m
487.7201 184.6414 l
487.7201 185.1415 l
575.9991 185.1415 l
f*
119.2045 184.6414 m
119.2045 172.1415 l
118.7045 172.1415 l
118.7045 184.6414 l
f*
118.7045 172.1415 m
36 172.1415 l
36 172.6415 l
118.7045 172.6415 l
f*
231.4346 184.6414 m
231.4346 172.1415 l
230.9346 172.1415 l
230.9346 184.6414 l
f*
230.9346 172.1415 m
119.2045 172.1415 l
119.2045 172.6415 l
230.9346 172.6415 l
f*
321.2935 184.6414 m
321.2935 172.1415 l
320.7934 172.1415 l
320.7934 184.6414 l
f*
320.7934 172.1415 m
231.4346 172.1415 l
231.4346 172.6415 l
320.7934 172.6415 l
f*
404.5068 184.6414 m
404.5068 172.1415 l
404.0067 172.1415 l
404.0067 184.6414 l
f*
404.0067 172.1415 m
321.2935 172.1415 l
321.2935 172.6415 l
404.0067 172.6415 l
f*
487.7201 184.6414 m
487.7201 172.1415 l
487.22 172.1415 l
487.22 184.6414 l
f*
487.22 172.1415 m
404.5068 172.1415 l
404.5068 172.6415 l
487.22 172.6415 l
f*
575.9991 172.1415 m
487.7201 172.1415 l
487.7201 172.6415 l
575.9991 172.6415 l
f*
119.2045 172.1415 m
119.2045 159.6416 l
118.7045 159.6416 l
118.7045 172.1415 l
f*
118.7045 159.6416 m
36 159.6416 l
36 160.1416 l
118.7045 160.1416 l
f*
231.4346 172.1415 m
231.4346 159.6416 l
230.9346 159.6416 l
230.9346 172.1415 l
f*
230.9346 159.6416 m
119.2045 159.6416 l
119.2045 160.1416 l
230.9346 160.1416 l
f*
321.2935 172.1415 m
321.2935 159.6416 l
320.7934 159.6416 l
320.7934 172.1415 l
f*
320.7934 159.6416 m
231.4346 159.6416 l
231.4346 160.1416 l
320.7934 160.1416 l
f*
404.5068 172.1415 m
404.5068 159.6416 l
404.0067 159.6416 l
404.0067 172.1415 l
f*
404.0067 159.6416 m
321.2935 159.6416 l
321.2935 160.1416 l
404.0067 160.1416 l
f*
487.7201 172.1415 m
487.7201 159.6416 l
487.22 159.6416 l
487.22 172.1415 l
f*
487.22 159.6416 m
404.5068 159.6416 l
404.5068 160.1416 l
487.22 160.1416 l
f*
575.9991 159.6416 m
487.7201 159.6416 l
487.7201 160.1416 l
575.9991 160.1416 l
f*
119.2045 159.6416 m
119.2045 147.1416 l
118.7045 147.1416 l
118.7045 159.6416 l
f*
118.7045 147.1416 m
36 147.1416 l
36 147.6417 l
118.7045 147.6417 l
f*
231.4346 159.6416 m
231.4346 147.1416 l
230.9346 147.1416 l
230.9346 159.6416 l
f*
230.9346 147.1416 m
119.2045 147.1416 l
119.2045 147.6417 l
230.9346 147.6417 l
f*
321.2935 159.6416 m
321.2935 147.1416 l
320.7934 147.1416 l
320.7934 159.6416 l
f*
320.7934 147.1416 m
231.4346 147.1416 l
231.4346 147.6417 l
320.7934 147.6417 l
f*
404.5068 159.6416 m
404.5068 147.1416 l
404.0067 147.1416 l
404.0067 159.6416 l
f*
404.0067 147.1416 m
321.2935 147.1416 l
321.2935 147.6417 l
404.0067 147.6417 l
f*
487.7201 159.6416 m
487.7201 147.1416 l
487.22 147.1416 l
487.22 159.6416 l
f*
487.22 147.1416 m
404.5068 147.1416 l
404.5068 147.6417 l
487.22 147.6417 l
f*
575.9991 147.1416 m
487.7201 147.1416 l
487.7201 147.6417 l
575.9991 147.6417 l
f*
575.9991 134.6417 m
36 134.6417 l
36 135.1417 l
575.9991 135.1417 l
f*
119.2045 134.6417 m
119.2045 122.1418 l
118.7045 122.1418 l
118.7045 134.6417 l
f*
118.7045 122.1418 m
36 122.1418 l
36 122.6418 l
118.7045 122.6418 l
f*
231.4346 134.6417 m
231.4346 122.1418 l
230.9346 122.1418 l
230.9346 134.6417 l
f*
230.9346 122.1418 m
119.2045 122.1418 l
119.2045 122.6418 l
230.9346 122.6418 l
f*
321.2935 134.6417 m
321.2935 122.1418 l
320.7934 122.1418 l
320.7934 134.6417 l
f*
320.7934 122.1418 m
231.4346 122.1418 l
231.4346 122.6418 l
320.7934 122.6418 l
f*
404.5068 134.6417 m
404.5068 122.1418 l
404.0067 122.1418 l
404.0067 134.6417 l
f*
404.0067 122.1418 m
321.2935 122.1418 l
321.2935 122.6418 l
404.0067 122.6418 l
f*
487.7201 134.6417 m
487.7201 122.1418 l
487.22 122.1418 l
487.22 134.6417 l
f*
487.22 122.1418 m
404.5068 122.1418 l
404.5068 122.6418 l
487.22 122.6418 l
f*
575.9991 122.1418 m
487.7201 122.1418 l
487.7201 122.6418 l
575.9991 122.6418 l
f*
119.2045 122.1418 m
119.2045 109.6418 l
118.7045 109.6418 l
118.7045 122.1418 l
f*
118.7045 109.6418 m
36 109.6418 l
36 110.1419 l
118.7045 110.1419 l
f*
231.4346 122.1418 m
231.4346 109.6418 l
230.9346 109.6418 l
230.9346 122.1418 l
f*
230.9346 109.6418 m
119.2045 109.6418 l
119.2045 110.1419 l
230.9346 110.1419 l
f*
321.2935 122.1418 m
321.2935 109.6418 l
320.7934 109.6418 l
320.7934 122.1418 l
f*
320.7934 109.6418 m
231.4346 109.6418 l
231.4346 110.1419 l
320.7934 110.1419 l
f*
404.5068 122.1418 m
404.5068 109.6418 l
404.0067 109.6418 l
404.0067 122.1418 l
f*
404.0067 109.6418 m
321.2935 109.6418 l
321.2935 110.1419 l
404.0067 110.1419 l
f*
487.7201 122.1418 m
487.7201 109.6418 l
487.22 109.6418 l
487.22 122.1418 l
f*
487.22 109.6418 m
404.5068 109.6418 l
404.5068 110.1419 l
487.22 110.1419 l
f*
575.9991 109.6418 m
487.7201 109.6418 l
487.7201 110.1419 l
575.9991 110.1419 l
f*
119.2045 109.6418 m
119.2045 97.1419 l
118.7045 97.1419 l
118.7045 109.6418 l
f*
118.7045 97.1419 m
36 97.1419 l
36 97.6419 l
118.7045 97.6419 l
f*
231.4346 109.6418 m
231.4346 97.1419 l
230.9346 97.1419 l
230.9346 109.6418 l
f*
230.9346 97.1419 m
119.2045 97.1419 l
119.2045 97.6419 l
230.9346 97.6419 l
f*
321.2935 109.6418 m
321.2935 97.1419 l
320.7934 97.1419 l
320.7934 109.6418 l
f*
320.7934 97.1419 m
231.4346 97.1419 l
231.4346 97.6419 l
320.7934 97.6419 l
f*
404.5068 109.6418 m
404.5068 97.1419 l
404.0067 97.1419 l
404.0067 109.6418 l
f*
404.0067 97.1419 m
321.2935 97.1419 l
321.2935 97.6419 l
404.0067 97.6419 l
f*
487.7201 109.6418 m
487.7201 97.1419 l
487.22 97.1419 l
487.22 109.6418 l
f*
487.22 97.1419 m
404.5068 97.1419 l
404.5068 97.6419 l
487.22 97.6419 l
f*
575.9991 97.1419 m
487.7201 97.1419 l
487.7201 97.6419 l
575.9991 97.6419 l
f*
0.83 0.64 0.02 0 k
36 84.0756 m
186.7465 84.0756 l
h
f*
0 g
7.9999 0 0 7.9999 36 214.9795 cm
BT
/F10 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.5512 0 Td
(1.)Tj
1.1763 0 Td
(Median)Tj
3.3804 0 Td
(lag)Tj
1.4386 0 Td
(times)Tj
2.4945 0 Td
(between)Tj
3.6071 0 Td
(onset)Tj
2.4378 0 Td
(of)Tj
1.063 0 Td
(symptoms)Tj
4.5071 0 Td
(and)Tj
1.7859 0 Td
(diagnosis)Tj
4.1102 0 Td
(in)Tj
1.063 0 Td
(CD)Tj
1.6442 0 Td
(and)Tj
1.7787 0 Td
(UC.)Tj
/F5 1 Tf
0 Tc
-4.0536 -1.8567 Td
(Follow-up)Tj
4.3654 0 Td
(time)Tj
2.0481 0 Td
(\(years\))Tj
-35.3979 -1.559 Td
(Group)Tj
10.7788 0 Td
(No.)Tj
1.7008 0 Td
(of)Tj
1.0275 0 Td
(patients)Tj
11.2962 0 Td
(Median)Tj
11.2324 0 Td
(P25%)Tj
10.4032 0 Td
(P75%)Tj
10.4032 0 Td
(p-value)Tj
-56.8421 -1.5662 Td
(Total)Tj
22.5568 0 Td
(911)Tj
11.4804 0 Td
(3,6)Tj
11.1119 0 Td
(0)Tj
9.6946 0 Td
(9,6)Tj
/F11 1 Tf
1.9984 0 Td
(<)Tj
/F5 1 Tf
(0,01)Tj
-56.8421 -1.559 Td
(UC)Tj
22.5568 0 Td
(483)Tj
11.4804 0 Td
(4,6)Tj
11.1119 0 Td
(0)Tj
9.2198 0 Td
(10,3)Tj
-54.3689 -1.5662 Td
(CD)Tj
22.5568 0 Td
(428)Tj
11.4804 0 Td
(2,1)Tj
11.1119 0 Td
(0)Tj
9.6946 0 Td
(8,6)Tj
-27.7868 -1.5591 Td
(Non-zer)Tj
3.359 0 Td
(o)Tj
0.7441 0 Td
(follow-up)Tj
4.1245 0 Td
(time)Tj
2.048 0 Td
(\(years\))Tj
-37.3325 -1.5661 Td
(Total)Tj
22.5568 0 Td
(589)Tj
11.4804 0 Td
(7,9)Tj
10.4033 0 Td
(3,9)Tj
9.9284 0 Td
(12,2)Tj
11.0977 0 Td
(0,86)Tj
-65.4666 -1.5591 Td
(UC)Tj
22.5568 0 Td
(349)Tj
12.1891 0 Td
(8)Tj
9.6946 0 Td
(3,7)Tj
9.9284 0 Td
(12,7)Tj
-54.3689 -1.5661 Td
(CD)Tj
22.5568 0 Td
(240)Tj
11.4804 0 Td
(7,7)Tj
10.4033 0 Td
(4,2)Tj
9.9284 0 Td
(11,9)Tj
0.83 0.64 0.02 0 k
/F8 1 Tf
-0.025 Tc
-54.3689 -1.8709 Td
(https://do)Tj
3.5575 0 Td
(i.org/10.1371/j)Tj
5.4425 0 Td
(ournal.pone)Tj
4.4079 0 Td
(.0200824.t001)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 417.3165 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Disease)Tj
3.7701 0 Td
(outcome)Tj
3.9968 0 Td
(in)Tj
0.978 0 Td
(IBD)Tj
1.8638 0 Td
(in)Tj
0.978 0 Td
(a)Tj
0.7653 0 Td
(Hungarian)Tj
4.7481 0 Td
(center)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.02008)Tj
4.089 0 Td
(24)Tj
0 g
2.0906 0 Td
(July)Tj
1.9701 0 Td
(30,)Tj
1.5874 0 Td
(2018)Tj
35.894 0 Td
(4)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
61 0 obj
<>stream
endstream
endobj
62 0 obj
<>stream
endstream
endobj
63 0 obj
<>stream
endstream
endobj
64 0 obj
<>stream
endstream
endobj
65 0 obj
<>stream
endstream
endobj
66 0 obj
<>stream
BT
66.9477 0 Td
(8)Tj
ET
Q
endstream
endobj
67 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 68 0 R/Contents 69 0 R/TrimBox[0 0 612 792]>>
endobj
68 0 obj
[70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R]
endobj
70 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref008)>>
endobj
71 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref009)>>
endobj
72 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref011)>>
endobj
73 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref012)>>
endobj
74 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref014)>>
endobj
75 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.t002)>>
endobj
76 0 obj
<>/Border[0 0 0]/A 78 0 R>>
endobj
78 0 obj
<>
endobj
77 0 obj
<>/Border[0 0 0]/A 79 0 R>>
endobj
79 0 obj
<>
endobj
69 0 obj
[80 0 R 81 0 R 82 0 R 83 0 R 84 0 R 85 0 R 86 0 R]
endobj
80 0 obj
<>stream
q
0.83 0.64 0.02 0 k
222.1795 154.7717 m
226.9417 154.7717 l
h
f*
423.4394 128.8063 m
428.2016 128.8063 l
h
f*
433.3606 128.8063 m
442.885 128.8063 l
h
f*
263.452 89.8016 m
272.9764 89.8016 l
h
f*
278.1354 89.8016 m
287.6598 89.8016 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 311.8677 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(lag)Tj
1.3662 0 Td
(time)Tj
2.024 0 Td
(between)Tj
3.5319 0 Td
(onset)Tj
2.3584 0 Td
(of)Tj
1.0148 0 Td
(symptoms)Tj
4.3597 0 Td
(and)Tj
1.7291 0 Td
(diagnosis)Tj
3.9571 0 Td
(proved)Tj
3.0218 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1508 0 Td
(significantly)Tj
5.0854 0 Td
(longer)Tj
2.7836 0 Td
(in)Tj
1.0374 0 Td
(UC)Tj
-34.4463 -1.2982 Td
(than)Tj
2.0295 0 Td
(in)Tj
1.0318 0 Td
(CD.)Tj
1.8482 0 Td
(33.5%)Tj
2.6306 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(patients)Tj
3.3675 0 Td
(underwent)Tj
4.5751 0 Td
(surgery)Tj
3.1918 0 Td
(required)Tj
3.6397 0 Td
(more)Tj
2.3414 0 Td
(frequently)Tj
4.3086 0 Td
(for)Tj
1.389 0 Td
(CD)Tj
1.6157 0 Td
(than)Tj
-34.452 -1.3039 Td
(UC.)Tj
1.8425 0 Td
(Biological)Tj
4.1669 0 Td
(therapy)Tj
3.2428 0 Td
(was)Tj
1.7008 0 Td
(given)Tj
2.381 0 Td
(for)Tj
1.3833 0 Td
(40%,)Tj
2.1544 0 Td
(immunomodulators)Tj
8.3111 0 Td
(for)Tj
1.3833 0 Td
(53%)Tj
1.9275 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(patients.)Tj
3.5887 0 Td
(More)Tj
-34.5711 -1.2983 Td
(patients)Tj
3.3675 0 Td
(needed)Tj
3.0954 0 Td
(surgery)Tj
3.1918 0 Td
(or)Tj
1.0998 0 Td
(biological)Tj
4.0876 0 Td
(therapy)Tj
3.2484 0 Td
(if)Tj
0.7767 0 Td
(they)Tj
1.9219 0 Td
(were)Tj
2.126 0 Td
(diagnosed)Tj
4.2803 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
2.0296 0 Td
(1)Tj
0.6916 0 Td
(year)Tj
1.9049 0 Td
(after)Tj
2.0352 0 Td
(the)Tj
-36.1981 -1.2983 Td
(onset)Tj
2.3584 0 Td
(of)Tj
1.0148 0 Td
(symptoms.)Tj
4.5807 0 Td
(Surgery)Tj
3.3109 0 Td
(was)Tj
1.7007 0 Td
(more)Tj
2.3414 0 Td
(common)Tj
3.8438 0 Td
(in)Tj
1.0375 0 Td
(CD)Tj
1.6157 0 Td
(patients)Tj
3.3732 0 Td
(with)Tj
1.9956 0 Td
(ileal)Tj
1.8368 0 Td
(location)Tj
3.4526 0 Td
(and)Tj
1.7291 0 Td
(pene-)Tj
-34.1912 -1.2982 Td
(trating)Tj
2.9026 0 Td
(behaviour)Tj
4.2406 0 Td
(but)Tj
1.5534 0 Td
(did)Tj
1.542 0 Td
(not)Tj
1.5704 0 Td
(show)Tj
2.3017 0 Td
(any)Tj
1.6554 0 Td
(association)Tj
4.6318 0 Td
(with)Tj
1.9956 0 Td
(disease)Tj
3.0161 0 Td
(extent)Tj
2.6815 0 Td
(of)Tj
1.0148 0 Td
(UC.)Tj
1.8425 0 Td
(Rate)Tj
1.9956 0 Td
(of)Tj
1.0148 0 Td
(surgery)Tj
-33.9588 -1.3039 Td
(was)Tj
1.6951 0 Td
(lower)Tj
2.4547 0 Td
(in)Tj
1.0375 0 Td
(patients)Tj
3.3676 0 Td
(treated)Tj
2.9933 0 Td
(with)Tj
2.0013 0 Td
(thiopurines)Tj
4.8358 0 Td
(in)Tj
1.0375 0 Td
(UC.)Tj
1.8425 0 Td
(Higher)Tj
3.0444 0 Td
(proportion)Tj
4.6318 0 Td
(of)Tj
1.0148 0 Td
(surgery)Tj
3.1918 0 Td
(was)Tj
1.7008 0 Td
(shown)Tj
-34.8489 -1.2983 Td
(in)Tj
1.0318 0 Td
(patient)Tj
3.0103 0 Td
(aged)Tj
2.0693 0 Td
(above)Tj
2.5455 0 Td
(40)Tj
1.1735 0 Td
(years)Tj
2.2621 0 Td
(in)Tj
1.0374 0 Td
(both)Tj
2.058 0 Td
(CD)Tj
1.6214 0 Td
(and)Tj
1.7291 0 Td
(UC.)Tj
1.8482 0 Td
(Use)Tj
1.7405 0 Td
(of)Tj
1.0148 0 Td
(oral)Tj
1.7744 0 Td
(contraceptives)Tj
5.9754 0 Td
(was)Tj
1.6951 0 Td
(protective)Tj
-32.5868 -1.2983 Td
(on)Tj
1.2755 0 Td
(surgery)Tj
3.1918 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4684 0 Td
(need)Tj
2.1429 0 Td
(of)Tj
1.0148 0 Td
(biological)Tj
4.0876 0 Td
(therapy)Tj
3.2484 0 Td
(and)Tj
1.7292 0 Td
(age)Tj
1.542 0 Td
(above)Tj
2.5455 0 Td
(40)Tj
1.1735 0 Td
(years)Tj
2.2621 0 Td
(also)Tj
1.7688 0 Td
(proved)Tj
3.0217 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(protec-)Tj
-34.384 -1.3039 Td
(tive)Tj
1.661 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4684 0 Td
(need)Tj
2.1486 0 Td
(of)Tj
1.0148 0 Td
(biologicals)Tj
4.4504 0 Td
(in)Tj
1.0318 0 Td
(both)Tj
2.0636 0 Td
(diseases.)Tj
-13.918 -1.2983 Td
(The)Tj
1.7858 0 Td
(overall)Tj
2.9026 0 Td
(prevalence)Tj
4.4844 0 Td
(and)Tj
1.7291 0 Td
(incidence)Tj
4.0762 0 Td
(of)Tj
1.0148 0 Td
(both)Tj
2.058 0 Td
(CD)Tj
1.6214 0 Td
(and)Tj
1.7291 0 Td
(UC)Tj
1.6214 0 Td
(is)Tj
0.8447 0 Td
(increasing)Tj
4.3313 0 Td
(worldwide.)Tj
4.6828 0 Td
(Previous)Tj
-34.0778 -1.2982 Td
(data)Tj
1.9105 0 Td
(suggested)Tj
4.0762 0 Td
(that)Tj
1.7801 0 Td
(approximately)Tj
5.9754 0 Td
(214%)Tj
2.9197 0 Td
(of)Tj
1.0148 0 Td
(patients)Tj
3.3675 0 Td
(with)Tj
1.9956 0 Td
(CD)Tj
1.6214 0 Td
(and)Tj
1.7291 0 Td
(UC)Tj
1.6214 0 Td
(have)Tj
2.058 0 Td
(a)Tj
0.6576 0 Td
(family)Tj
2.7269 0 Td
(history)Tj
3.0047 0 Td
(of)Tj
-36.4589 -1.3039 Td
(IBD)Tj
1.8765 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(].)Tj
1.5987 0 Td
(Our)Tj
1.8652 0 Td
(data)Tj
1.9162 0 Td
(revealed)Tj
3.5263 0 Td
(a)Tj
0.6519 0 Td
(bit)Tj
1.2926 0 Td
(higher)Tj
2.8006 0 Td
(proportion)Tj
4.6318 0 Td
(of)Tj
1.0148 0 Td
(IBD)Tj
1.8765 0 Td
(patients)Tj
3.3676 0 Td
(having)Tj
2.9196 0 Td
(positive)Tj
3.3166 0 Td
(family)Tj
2.7269 0 Td
(his-)Tj
-35.3818 -1.2983 Td
(tory)Tj
1.8481 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(disease.)Tj
3.2428 0 Td
(Smoking)Tj
3.7984 0 Td
(is)Tj
0.8448 0 Td
(one)Tj
1.7007 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(most)Tj
2.2053 0 Td
(consistently)Tj
4.9606 0 Td
(examined)Tj
4.1272 0 Td
(risk)Tj
1.7178 0 Td
(factors)Tj
2.9027 0 Td
(in)Tj
1.0375 0 Td
(IBD)Tj
1.8765 0 Td
(being)Tj
-35.2344 -1.2983 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9955 0 Td
(a)Tj
0.652 0 Td
(more)Tj
2.3414 0 Td
(aggressive)Tj
4.2463 0 Td
(disease)Tj
3.0217 0 Td
(course)Tj
2.829 0 Td
(in)Tj
1.0374 0 Td
(CD)Tj
1.6214 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(].)Tj
3.0671 0 Td
(In)Tj
1.1112 0 Td
(our)Tj
1.627 0 Td
(cohort,)Tj
3.0785 0 Td
(smoking)Tj
3.685 0 Td
(did)Tj
1.542 0 Td
(not)Tj
-36.1131 -1.2982 Td
(prove)Tj
2.4944 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1451 0 Td
(a)Tj
0.6577 0 Td
(predictor)Tj
3.9231 0 Td
(of)Tj
1.0148 0 Td
(unfavourable)Tj
5.4935 0 Td
(disease)Tj
3.0161 0 Td
(outcome)Tj
3.7247 0 Td
(despite)Tj
3.0387 0 Td
(the)Tj
1.474 0 Td
(proportion)Tj
4.6318 0 Td
(of)Tj
1.0148 0 Td
(current)Tj
-32.6549 -1.3039 Td
(smokers)Tj
3.5602 0 Td
(was)Tj
1.6951 0 Td
(significantly)Tj
5.091 0 Td
(higher)Tj
2.8007 0 Td
(in)Tj
1.0374 0 Td
(CD)Tj
1.6214 0 Td
(vs.)Tj
1.2586 0 Td
(UC.)Tj
1.8482 0 Td
(Appendectomy)Tj
6.3609 0 Td
(also)Tj
1.7688 0 Td
(shows)Tj
2.6645 0 Td
(different)Tj
3.6511 0 Td
(effects)Tj
-33.3579 -1.2983 Td
(in)Tj
1.0318 0 Td
(CD)Tj
1.6214 0 Td
(and)Tj
1.7291 0 Td
(UC)Tj
1.6214 0 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(],)Tj
3.5433 0 Td
(however,)Tj
3.8381 0 Td
(our)Tj
1.627 0 Td
(results)Tj
2.812 0 Td
(could)Tj
2.4491 0 Td
(not)Tj
1.5761 0 Td
(confirm)Tj
3.4412 0 Td
(that)Tj
1.7801 0 Td
(appendectomy)Tj
6.1172 0 Td
(was)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
199.9998 703.8893 m
575.9997 703.8893 l
575.9997 703.3893 l
199.9998 703.3893 l
f*
362.3732 703.3893 m
362.3732 690.8893 l
361.8731 690.8893 l
361.8731 703.3893 l
f*
361.8731 690.8893 m
199.9998 690.8893 l
199.9998 691.3894 l
361.8731 691.3894 l
f*
469.561 703.3893 m
469.561 690.8893 l
469.061 690.8893 l
469.061 703.3893 l
f*
469.061 690.8893 m
362.3732 690.8893 l
362.3732 691.3894 l
469.061 691.3894 l
f*
575.9997 690.8893 m
469.561 690.8893 l
469.561 691.3894 l
575.9997 691.3894 l
f*
362.3732 690.8893 m
362.3732 678.3894 l
361.8731 678.3894 l
361.8731 690.8893 l
f*
361.8731 678.3894 m
199.9998 678.3894 l
199.9998 678.8894 l
361.8731 678.8894 l
f*
469.561 690.8893 m
469.561 678.3894 l
469.061 678.3894 l
469.061 690.8893 l
f*
469.061 678.3894 m
362.3732 678.3894 l
362.3732 678.8894 l
469.061 678.8894 l
f*
575.9997 678.3894 m
469.561 678.3894 l
469.561 678.8894 l
575.9997 678.8894 l
f*
362.3732 678.3894 m
362.3732 665.8894 l
361.8731 665.8894 l
361.8731 678.3894 l
f*
361.8731 665.8894 m
199.9998 665.8894 l
199.9998 666.3895 l
361.8731 666.3895 l
f*
469.561 678.3894 m
469.561 665.8894 l
469.061 665.8894 l
469.061 678.3894 l
f*
469.061 665.8894 m
362.3732 665.8894 l
362.3732 666.3895 l
469.061 666.3895 l
f*
575.9997 665.8894 m
469.561 665.8894 l
469.561 666.3895 l
575.9997 666.3895 l
f*
362.3732 665.8894 m
362.3732 653.3895 l
361.8731 653.3895 l
361.8731 665.8894 l
f*
361.8731 653.3895 m
199.9998 653.3895 l
199.9998 653.8895 l
361.8731 653.8895 l
f*
469.561 665.8894 m
469.561 653.3895 l
469.061 653.3895 l
469.061 665.8894 l
f*
469.061 653.3895 m
362.3732 653.3895 l
362.3732 653.8895 l
469.061 653.8895 l
f*
575.9997 653.3895 m
469.561 653.3895 l
469.561 653.8895 l
575.9997 653.8895 l
f*
362.3732 653.3895 m
362.3732 640.8896 l
361.8731 640.8896 l
361.8731 653.3895 l
f*
361.8731 640.8896 m
199.9998 640.8896 l
199.9998 641.3896 l
361.8731 641.3896 l
f*
469.561 653.3895 m
469.561 640.8896 l
469.061 640.8896 l
469.061 653.3895 l
f*
469.061 640.8896 m
362.3732 640.8896 l
362.3732 641.3896 l
469.061 641.3896 l
f*
575.9997 640.8896 m
469.561 640.8896 l
469.561 641.3896 l
575.9997 641.3896 l
f*
362.3732 640.8896 m
362.3732 628.3896 l
361.8731 628.3896 l
361.8731 640.8896 l
f*
361.8731 628.3896 m
199.9998 628.3896 l
199.9998 628.8897 l
361.8731 628.8897 l
f*
469.561 640.8896 m
469.561 628.3896 l
469.061 628.3896 l
469.061 640.8896 l
f*
469.061 628.3896 m
362.3732 628.3896 l
362.3732 628.8897 l
469.061 628.8897 l
f*
575.9997 628.3896 m
469.561 628.3896 l
469.561 628.8897 l
575.9997 628.8897 l
f*
362.3732 628.3896 m
362.3732 615.8897 l
361.8731 615.8897 l
361.8731 628.3896 l
f*
361.8731 615.8897 m
199.9998 615.8897 l
199.9998 616.3897 l
361.8731 616.3897 l
f*
469.561 628.3896 m
469.561 615.8897 l
469.061 615.8897 l
469.061 628.3896 l
f*
469.061 615.8897 m
362.3732 615.8897 l
362.3732 616.3897 l
469.061 616.3897 l
f*
575.9997 615.8897 m
469.561 615.8897 l
469.561 616.3897 l
575.9997 616.3897 l
f*
362.3732 615.8897 m
362.3732 603.3898 l
361.8731 603.3898 l
361.8731 615.8897 l
f*
361.8731 603.3898 m
199.9998 603.3898 l
199.9998 603.8898 l
361.8731 603.8898 l
f*
469.561 615.8897 m
469.561 603.3898 l
469.061 603.3898 l
469.061 615.8897 l
f*
469.061 603.3898 m
362.3732 603.3898 l
362.3732 603.8898 l
469.061 603.8898 l
f*
575.9997 603.3898 m
469.561 603.3898 l
469.561 603.8898 l
575.9997 603.8898 l
f*
362.3732 603.3898 m
362.3732 590.8898 l
361.8731 590.8898 l
361.8731 603.3898 l
f*
361.8731 590.8898 m
199.9998 590.8898 l
199.9998 591.3899 l
361.8731 591.3899 l
f*
469.561 603.3898 m
469.561 590.8898 l
469.061 590.8898 l
469.061 603.3898 l
f*
469.061 590.8898 m
362.3732 590.8898 l
362.3732 591.3899 l
469.061 591.3899 l
f*
575.9997 590.8898 m
469.561 590.8898 l
469.561 591.3899 l
575.9997 591.3899 l
f*
362.3732 590.8898 m
362.3732 578.3899 l
361.8731 578.3899 l
361.8731 590.8898 l
f*
361.8731 578.3899 m
199.9998 578.3899 l
199.9998 578.8899 l
361.8731 578.8899 l
f*
469.561 590.8898 m
469.561 578.3899 l
469.061 578.3899 l
469.061 590.8898 l
f*
469.061 578.3899 m
362.3732 578.3899 l
362.3732 578.8899 l
469.061 578.8899 l
f*
575.9997 578.3899 m
469.561 578.3899 l
469.561 578.8899 l
575.9997 578.8899 l
f*
362.3732 578.3899 m
362.3732 565.89 l
361.8731 565.89 l
361.8731 578.3899 l
f*
361.8731 565.89 m
199.9998 565.89 l
199.9998 566.39 l
361.8731 566.39 l
f*
469.561 578.3899 m
469.561 565.89 l
469.061 565.89 l
469.061 578.3899 l
f*
469.061 565.89 m
362.3732 565.89 l
362.3732 566.39 l
469.061 566.39 l
f*
575.9997 565.89 m
469.561 565.89 l
469.561 566.39 l
575.9997 566.39 l
f*
362.3732 565.89 m
362.3732 553.39 l
361.8731 553.39 l
361.8731 565.89 l
f*
361.8731 553.39 m
199.9998 553.39 l
199.9998 553.89 l
361.8731 553.89 l
f*
469.561 565.89 m
469.561 553.39 l
469.061 553.39 l
469.061 565.89 l
f*
469.061 553.39 m
362.3732 553.39 l
362.3732 553.89 l
469.061 553.89 l
f*
575.9997 553.39 m
469.561 553.39 l
469.561 553.89 l
575.9997 553.89 l
f*
362.3732 553.39 m
362.3732 540.8901 l
361.8731 540.8901 l
361.8731 553.39 l
f*
361.8731 540.8901 m
199.9998 540.8901 l
199.9998 541.3901 l
361.8731 541.3901 l
f*
469.561 553.39 m
469.561 540.8901 l
469.061 540.8901 l
469.061 553.39 l
f*
469.061 540.8901 m
362.3732 540.8901 l
362.3732 541.3901 l
469.061 541.3901 l
f*
575.9997 540.8901 m
469.561 540.8901 l
469.561 541.3901 l
575.9997 541.3901 l
f*
362.3732 540.8901 m
362.3732 528.3901 l
361.8731 528.3901 l
361.8731 540.8901 l
f*
361.8731 528.3901 m
199.9998 528.3901 l
199.9998 528.8902 l
361.8731 528.8902 l
f*
469.561 540.8901 m
469.561 528.3901 l
469.061 528.3901 l
469.061 540.8901 l
f*
469.061 528.3901 m
362.3732 528.3901 l
362.3732 528.8902 l
469.061 528.8902 l
f*
575.9997 528.3901 m
469.561 528.3901 l
469.561 528.8902 l
575.9997 528.8902 l
f*
362.3732 528.3901 m
362.3732 515.8902 l
361.8731 515.8902 l
361.8731 528.3901 l
f*
361.8731 515.8902 m
199.9998 515.8902 l
199.9998 516.3902 l
361.8731 516.3902 l
f*
469.561 528.3901 m
469.561 515.8902 l
469.061 515.8902 l
469.061 528.3901 l
f*
469.061 515.8902 m
362.3732 515.8902 l
362.3732 516.3902 l
469.061 516.3902 l
f*
575.9997 515.8902 m
469.561 515.8902 l
469.561 516.3902 l
575.9997 516.3902 l
f*
362.3732 515.8902 m
362.3732 503.3903 l
361.8731 503.3903 l
361.8731 515.8902 l
f*
361.8731 503.3903 m
199.9998 503.3903 l
199.9998 503.8903 l
361.8731 503.8903 l
f*
469.561 515.8902 m
469.561 503.3903 l
469.061 503.3903 l
469.061 515.8902 l
f*
469.061 503.3903 m
362.3732 503.3903 l
362.3732 503.8903 l
469.061 503.8903 l
f*
575.9997 503.3903 m
469.561 503.3903 l
469.561 503.8903 l
575.9997 503.8903 l
f*
362.3732 503.3903 m
362.3732 490.8903 l
361.8731 490.8903 l
361.8731 503.3903 l
f*
361.8731 490.8903 m
199.9998 490.8903 l
199.9998 491.3904 l
361.8731 491.3904 l
f*
469.561 503.3903 m
469.561 490.8903 l
469.061 490.8903 l
469.061 503.3903 l
f*
469.061 490.8903 m
362.3732 490.8903 l
362.3732 491.3904 l
469.061 491.3904 l
f*
575.9997 490.8903 m
469.561 490.8903 l
469.561 491.3904 l
575.9997 491.3904 l
f*
362.3732 490.8903 m
362.3732 478.3904 l
361.8731 478.3904 l
361.8731 490.8903 l
f*
361.8731 478.3904 m
199.9998 478.3904 l
199.9998 478.8904 l
361.8731 478.8904 l
f*
469.561 490.8903 m
469.561 478.3904 l
469.061 478.3904 l
469.061 490.8903 l
f*
469.061 478.3904 m
362.3732 478.3904 l
362.3732 478.8904 l
469.061 478.8904 l
f*
575.9997 478.3904 m
469.561 478.3904 l
469.561 478.8904 l
575.9997 478.8904 l
f*
362.3732 478.3904 m
362.3732 465.8905 l
361.8731 465.8905 l
361.8731 478.3904 l
f*
361.8731 465.8905 m
199.9998 465.8905 l
199.9998 466.3905 l
361.8731 466.3905 l
f*
469.561 478.3904 m
469.561 465.8905 l
469.061 465.8905 l
469.061 478.3904 l
f*
469.061 465.8905 m
362.3732 465.8905 l
362.3732 466.3905 l
469.061 466.3905 l
f*
575.9997 465.8905 m
469.561 465.8905 l
469.561 466.3905 l
575.9997 466.3905 l
f*
362.3732 465.8905 m
362.3732 453.3905 l
361.8731 453.3905 l
361.8731 465.8905 l
f*
361.8731 453.3905 m
199.9998 453.3905 l
199.9998 453.8906 l
361.8731 453.8906 l
f*
469.561 465.8905 m
469.561 453.3905 l
469.061 453.3905 l
469.061 465.8905 l
f*
469.061 453.3905 m
362.3732 453.3905 l
362.3732 453.8906 l
469.061 453.8906 l
f*
575.9997 453.3905 m
469.561 453.3905 l
469.561 453.8906 l
575.9997 453.8906 l
f*
362.3732 453.3905 m
362.3732 440.8906 l
361.8731 440.8906 l
361.8731 453.3905 l
f*
361.8731 440.8906 m
199.9998 440.8906 l
199.9998 441.3906 l
361.8731 441.3906 l
f*
469.561 453.3905 m
469.561 440.8906 l
469.061 440.8906 l
469.061 453.3905 l
f*
469.061 440.8906 m
362.3732 440.8906 l
362.3732 441.3906 l
469.061 441.3906 l
f*
575.9997 440.8906 m
469.561 440.8906 l
469.561 441.3906 l
575.9997 441.3906 l
f*
362.3732 440.8906 m
362.3732 428.3906 l
361.8731 428.3906 l
361.8731 440.8906 l
f*
361.8731 428.3906 m
199.9998 428.3906 l
199.9998 428.8907 l
361.8731 428.8907 l
f*
469.561 440.8906 m
469.561 428.3906 l
469.061 428.3906 l
469.061 440.8906 l
f*
469.061 428.3906 m
362.3732 428.3906 l
362.3732 428.8907 l
469.061 428.8907 l
f*
575.9997 428.3906 m
469.561 428.3906 l
469.561 428.8907 l
575.9997 428.8907 l
f*
362.3732 428.3906 m
362.3732 415.8907 l
361.8731 415.8907 l
361.8731 428.3906 l
f*
361.8731 415.8907 m
199.9998 415.8907 l
199.9998 416.3907 l
361.8731 416.3907 l
f*
469.561 428.3906 m
469.561 415.8907 l
469.061 415.8907 l
469.061 428.3906 l
f*
469.061 415.8907 m
362.3732 415.8907 l
362.3732 416.3907 l
469.061 416.3907 l
f*
575.9997 415.8907 m
469.561 415.8907 l
469.561 416.3907 l
575.9997 416.3907 l
f*
362.3732 415.8907 m
362.3732 403.3908 l
361.8731 403.3908 l
361.8731 415.8907 l
f*
361.8731 403.3908 m
199.9998 403.3908 l
199.9998 403.8908 l
361.8731 403.8908 l
f*
469.561 415.8907 m
469.561 403.3908 l
469.061 403.3908 l
469.061 415.8907 l
f*
469.061 403.3908 m
362.3732 403.3908 l
362.3732 403.8908 l
469.061 403.8908 l
f*
575.9997 403.3908 m
469.561 403.3908 l
469.561 403.8908 l
575.9997 403.8908 l
f*
362.3732 403.3908 m
362.3732 390.8908 l
361.8731 390.8908 l
361.8731 403.3908 l
f*
361.8731 390.8908 m
199.9998 390.8908 l
199.9998 391.3909 l
361.8731 391.3909 l
f*
469.561 403.3908 m
469.561 390.8908 l
469.061 390.8908 l
469.061 403.3908 l
f*
469.061 390.8908 m
362.3732 390.8908 l
362.3732 391.3909 l
469.061 391.3909 l
f*
575.9997 390.8908 m
469.561 390.8908 l
469.561 391.3909 l
575.9997 391.3909 l
f*
362.3732 390.8908 m
362.3732 378.3909 l
361.8731 378.3909 l
361.8731 390.8908 l
f*
361.8731 378.3909 m
199.9998 378.3909 l
199.9998 378.8909 l
361.8731 378.8909 l
f*
469.561 390.8908 m
469.561 378.3909 l
469.061 378.3909 l
469.061 390.8908 l
f*
469.061 378.3909 m
362.3732 378.3909 l
362.3732 378.8909 l
469.061 378.8909 l
f*
575.9997 378.3909 m
469.561 378.3909 l
469.561 378.8909 l
575.9997 378.8909 l
f*
362.3732 378.3909 m
362.3732 365.891 l
361.8731 365.891 l
361.8731 378.3909 l
f*
361.8731 365.891 m
199.9998 365.891 l
199.9998 366.391 l
361.8731 366.391 l
f*
469.561 378.3909 m
469.561 365.891 l
469.061 365.891 l
469.061 378.3909 l
f*
469.061 365.891 m
362.3732 365.891 l
362.3732 366.391 l
469.061 366.391 l
f*
575.9997 365.891 m
469.561 365.891 l
469.561 366.391 l
575.9997 366.391 l
f*
362.3732 365.891 m
362.3732 353.391 l
361.8731 353.391 l
361.8731 365.891 l
f*
361.8731 353.391 m
199.9998 353.391 l
199.9998 353.8911 l
361.8731 353.8911 l
f*
469.561 365.891 m
469.561 353.391 l
469.061 353.391 l
469.061 365.891 l
f*
469.061 353.391 m
362.3732 353.391 l
362.3732 353.8911 l
469.061 353.8911 l
f*
575.9997 353.391 m
469.561 353.391 l
469.561 353.8911 l
575.9997 353.8911 l
f*
0.83 0.64 0.02 0 k
200.0126 340.3276 m
350.7591 340.3276 l
h
f*
0 g
7.9999 0 0 7.9999 200.0125 708.7181 cm
BT
/F10 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.5512 0 Td
(2.)Tj
1.1763 0 Td
(Demograp)Tj
4.4221 0 Td
(hic)Tj
1.474 0 Td
(and)Tj
1.7859 0 Td
(clinical)Tj
3.2032 0 Td
(character)Tj
3.8764 0 Td
(istics)Tj
2.3102 0 Td
(of)Tj
1.063 0 Td
(the)Tj
1.5307 0 Td
(enrolled)Tj
3.6497 0 Td
(patients)Tj
3.3307 0 Td
(.)Tj
0 Tc
-7.9441 -1.8567 Td
(CD)Tj
1.6653 0 Td
(patients)Tj
3.6071 0 Td
(\(n)Tj
1.141 0 Td
(=)Tj
0.8008 0 Td
(428\))Tj
6.1867 0 Td
(UC)Tj
1.6299 0 Td
(patients)Tj
3.6071 0 Td
(\(n)Tj
1.141 0 Td
(=)Tj
0.8078 0 Td
(483\))Tj
-43.016 -1.559 Td
(Mean)Tj
2.5724 0 Td
(age)Tj
1.6229 0 Td
(at)Tj
1.0417 0 Td
(the)Tj
1.5591 0 Td
(present)Tj
3.3449 0 Td
(\(years\))Tj
/F5 1 Tf
12.8623 0 Td
(41.2)Tj
/F12 1 Tf
[()]TJ
/F5 1 Tf
(13.8)Tj
4.1244 0 Td
(\(SD:0.67\))Tj
9.2623 0 Td
(47.4)Tj
/F12 1 Tf
[()]TJ
/F5 1 Tf
(15.2)Tj
4.1244 0 Td
(\(SD:0.69)Tj
3.4442 0 Td
(\))Tj
/F10 1 Tf
-43.9586 -1.5662 Td
(Mean)Tj
2.5724 0 Td
(age)Tj
1.6229 0 Td
(at)Tj
1.0417 0 Td
(diagnosis)Tj
4.167 0 Td
(\(years\))Tj
/F5 1 Tf
15.6119 0 Td
(27.9)Tj
/F12 1 Tf
[()]TJ
/F5 1 Tf
(11.4)Tj
13.3867 0 Td
(30.9)Tj
/F12 1 Tf
[()]TJ
/F5 1 Tf
(12)Tj
3.1819 0 Td
(.5)Tj
/F10 1 Tf
-41.5845 -1.559 Td
(Mean)Tj
2.5724 0 Td
(age)Tj
1.6229 0 Td
(at)Tj
1.0417 0 Td
(onset)Tj
2.4732 0 Td
(of)Tj
1.0772 0 Td
(symptoms)Tj
4.5638 0 Td
(\(years\))Tj
/F5 1 Tf
9.5387 0 Td
(26.6)Tj
/F12 1 Tf
[()]TJ
/F5 1 Tf
(11.3)Tj
4.1244 0 Td
(\(SD:)Tj
2.0197 0 Td
(0.56\))Tj
7.356 0 Td
(30.3)Tj
/F12 1 Tf
[()]TJ
/F5 1 Tf
(12.4)Tj
4.1244 0 Td
(\(SD:0.58)Tj
3.4442 0 Td
(\))Tj
/F10 1 Tf
-43.9586 -1.5662 Td
(Male/fema)Tj
4.4646 0 Td
(le)Tj
0.9425 0 Td
(ratio)Tj
/F5 1 Tf
19.956 0 Td
(194/234)Tj
13.3868 0 Td
(228/255)Tj
/F10 1 Tf
-38.7499 -1.5591 Td
(Smoking)Tj
3.9331 0 Td
(habits)Tj
2.7992 0 Td
(\(n,)Tj
1.389 0 Td
(%\))Tj
/F5 1 Tf
-8.1213 -1.559 Td
(-)Tj
/F10 1 Tf
0.5811 0 Td
(Ex)Tj
1.2897 0 Td
(smoker)Tj
/F5 1 Tf
22.2026 0 Td
(109/385)Tj
3.4299 0 Td
(\(28.3\))Tj
10.3111 0 Td
(148/448)Tj
3.4229 0 Td
(\(33\))Tj
-41.2373 -1.5662 Td
(-)Tj
/F10 1 Tf
0.5811 0 Td
(Current)Tj
3.6071 0 Td
(smoker)Tj
/F5 1 Tf
19.8852 0 Td
(107/385)Tj
3.4299 0 Td
(\(27.8\))Tj
10.4316 0 Td
(37/448)Tj
2.9551 0 Td
(\(8.2\))Tj
-40.89 -1.5591 Td
(-)Tj
/F10 1 Tf
0.5811 0 Td
(Never)Tj
2.7142 0 Td
(smoked)Tj
/F5 1 Tf
20.7781 0 Td
(169/385)Tj
3.4299 0 Td
(\(43.9\))Tj
9.9568 0 Td
(263/448)Tj
3.4299 0 Td
(\(58.7\))Tj
/F10 1 Tf
-40.89 -1.5661 Td
(Appendect)Tj
4.5567 0 Td
(omy)Tj
2.0551 0 Td
(\(n,)Tj
1.3961 0 Td
(%\))Tj
/F5 1 Tf
16.3064 0 Td
(76/378)Tj
2.9481 0 Td
(\(20.1\))Tj
10.6725 0 Td
(26/448)Tj
2.9551 0 Td
(\(5.8\))Tj
/F10 1 Tf
-40.89 -1.5591 Td
(Use)Tj
1.7787 0 Td
(of)Tj
1.0772 0 Td
(oral)Tj
1.9063 0 Td
(contra)Tj
2.7142 0 Td
(ceptives)Tj
3.5646 0 Td
(\(n,)Tj
1.3961 0 Td
(%\))Tj
/F5 1 Tf
11.9906 0 Td
(119/372)Tj
3.4299 0 Td
(\(32\))Tj
9.6025 0 Td
(146/437)Tj
3.4299 0 Td
(\(33.4\))Tj
/F10 1 Tf
-40.89 -1.5661 Td
(Location)Tj
3.6708 0 Td
(/extent)Tj
3.1536 0 Td
(\(n,)Tj
1.389 0 Td
(%\))Tj
/F5 1 Tf
-8.2134 -1.5591 Td
(-)Tj
/F10 1 Tf
0.5811 0 Td
(Ileal)Tj
/F5 1 Tf
24.3781 0 Td
(110)Tj
1.6654 0 Td
(\(25.7\))Tj
13.0111 0 Td
(NA)Tj
-39.6357 -1.5662 Td
(-)Tj
/F10 1 Tf
0.5811 0 Td
(Colonic)Tj
/F5 1 Tf
24.3781 0 Td
(156)Tj
1.6654 0 Td
(\(34.6\))Tj
13.0111 0 Td
(NA)Tj
-39.6357 -1.559 Td
(-)Tj
/F10 1 Tf
0.5811 0 Td
(Ileocolon)Tj
3.9118 0 Td
(ic)Tj
/F5 1 Tf
20.4663 0 Td
(151)Tj
1.6654 0 Td
(\(35.3\))Tj
13.0111 0 Td
(NA)Tj
-39.6357 -1.5662 Td
(-)Tj
/F10 1 Tf
0.5811 0 Td
(Isolated)Tj
3.5858 0 Td
(upper)Tj
2.7213 0 Td
(GI)Tj
/F5 1 Tf
18.5458 0 Td
(11)Tj
1.1906 0 Td
(\(2.6\))Tj
13.0111 0 Td
(NA)Tj
-39.6357 -1.559 Td
(-)Tj
/F10 1 Tf
0.5811 0 Td
(Proctitis)Tj
/F5 1 Tf
25.6679 0 Td
(NA)Tj
12.0898 0 Td
(165)Tj
1.6654 0 Td
(\(34.2\))Tj
-40.0042 -1.5662 Td
(-)Tj
/F10 1 Tf
0.5811 0 Td
(Left-sided)Tj
4.4433 0 Td
(colitis)Tj
/F5 1 Tf
21.2246 0 Td
(NA)Tj
12.0898 0 Td
(167)Tj
1.6654 0 Td
(\(34.6\))Tj
-40.0042 -1.5591 Td
(-)Tj
/F10 1 Tf
0.5811 0 Td
(Extensive)Tj
4.2094 0 Td
(colitis)Tj
/F5 1 Tf
21.4585 0 Td
(NA)Tj
12.0898 0 Td
(151)Tj
1.6654 0 Td
(\(31.3\))Tj
/F10 1 Tf
-39.083 -1.5661 Td
(Behavio)Tj
3.3591 0 Td
(ur)Tj
1.1906 0 Td
(\(n,)Tj
1.3889 0 Td
(%\))Tj
-5.9386 -1.5591 Td
(-Non-st)Tj
3.2245 0 Td
(ricturing,)Tj
4.2378 0 Td
(non-penet)Tj
4.3087 0 Td
(rating)Tj
/F5 1 Tf
12.267 0 Td
(190)Tj
1.6654 0 Td
(\(44.4\))Tj
13.0111 0 Td
(NA)Tj
/F10 1 Tf
-38.7145 -1.5661 Td
(-Strictur)Tj
3.6 0 Td
(ing)Tj
/F5 1 Tf
20.438 0 Td
(101)Tj
1.6654 0 Td
(\(23.6\))Tj
13.0111 0 Td
(NA)Tj
/F10 1 Tf
-38.7145 -1.5591 Td
(-Penet)Tj
2.7142 0 Td
(rating)Tj
/F5 1 Tf
21.3238 0 Td
(136)Tj
1.6654 0 Td
(\(31.8\))Tj
13.0111 0 Td
(NA)Tj
/F10 1 Tf
-38.7145 -1.5662 Td
(-Perianal)Tj
4.0819 0 Td
(manifest)Tj
3.6497 0 Td
(ation)Tj
/F5 1 Tf
16.5473 0 Td
(63)Tj
1.1835 0 Td
(\(14.7\))Tj
13.2521 0 Td
(NA)Tj
/F10 1 Tf
-38.7145 -1.559 Td
(Extraintes)Tj
4.2875 0 Td
(tinal)Tj
2.1685 0 Td
(manifestat)Tj
4.4646 0 Td
(ions)Tj
1.9842 0 Td
(\(n,)Tj
1.3961 0 Td
(%\))Tj
/F5 1 Tf
-13.3867 -1.5662 Td
(-)Tj
/F10 1 Tf
0.5882 0 Td
(Eye)Tj
/F5 1 Tf
23.0104 0 Td
(27)Tj
1.1906 0 Td
(\(6.3\))Tj
12.1961 0 Td
(18)Tj
1.1835 0 Td
(\(3.7\))Tj
-38.1688 -1.559 Td
(-)Tj
/F10 1 Tf
0.5882 0 Td
(Skin)Tj
/F5 1 Tf
22.7765 0 Td
(55)Tj
1.1835 0 Td
(\(12.9\))Tj
12.1962 0 Td
(69)Tj
1.1835 0 Td
(\(14.3\))Tj
-37.9279 -1.5662 Td
(-)Tj
/F10 1 Tf
0.5882 0 Td
(Joint)Tj
/F5 1 Tf
22.8899 0 Td
(231)Tj
1.6583 0 Td
(\(54\))Tj
11.367 0 Td
(279)Tj
1.6654 0 Td
(\(57.8\))Tj
0.83 0.64 0.02 0 k
/F8 1 Tf
-0.025 Tc
-40.0042 -1.8709 Td
(https://d)Tj
3.0827 0 Td
(oi.org/10.1371/j)Tj
5.9173 0 Td
(ournal.pon)Tj
3.9827 0 Td
(e.0200824.t00)Tj
5.3859 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 417.3165 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Disease)Tj
3.7701 0 Td
(outcome)Tj
3.9968 0 Td
(in)Tj
0.978 0 Td
(IBD)Tj
1.8638 0 Td
(in)Tj
0.978 0 Td
(a)Tj
0.7653 0 Td
(Hungarian)Tj
4.7481 0 Td
(center)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.02008)Tj
4.089 0 Td
(24)Tj
0 g
2.0906 0 Td
(July)Tj
1.9701 0 Td
(30,)Tj
1.5874 0 Td
(2018)Tj
35.894 0 Td
(5)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
81 0 obj
<>stream
endstream
endobj
82 0 obj
<>stream
endstream
endobj
83 0 obj
<>stream
endstream
endobj
84 0 obj
<>stream
endstream
endobj
85 0 obj
<>stream
endstream
endobj
86 0 obj
<>stream
BT
66.9477 0 Td
(8)Tj
ET
Q
endstream
endobj
87 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 88 0 R/Contents 89 0 R/TrimBox[0 0 612 792]>>
endobj
88 0 obj
[90 0 R 91 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R 98 0 R 99 0 R 100 0 R 101 0 R 102 0 R 103 0 R 104 0 R 105 0 R 106 0 R]
endobj
90 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref015)>>
endobj
91 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref016)>>
endobj
92 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref017)>>
endobj
93 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref015)>>
endobj
94 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref016)>>
endobj
95 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref017)>>
endobj
96 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref015)>>
endobj
97 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref017)>>
endobj
98 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref017)>>
endobj
99 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref016)>>
endobj
100 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref018)>>
endobj
101 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref016)>>
endobj
102 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref019)>>
endobj
103 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref020)>>
endobj
104 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref021)>>
endobj
105 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200824.ref022)>>
endobj
106 0 obj
<>/Border[0 0 0]/A 107 0 R>>
endobj
107 0 obj
<>
endobj
89 0 obj
[108 0 R 109 0 R 110 0 R 111 0 R 112 0 R 113 0 R 114 0 R 115 0 R 116 0 R]
endobj
108 0 obj
<>stream
q
0.83 0.64 0.02 0 k
242.9858 654.3496 m
252.5102 654.3496 l
h
f*
427.2945 641.3102 m
436.8189 641.3102 l
h
f*
358.8094 602.3055 m
368.3339 602.3055 l
h
f*
535.9181 511.3134 m
545.4425 511.3134 l
h
f*
549.9213 511.3134 m
559.4457 511.3134 l
h
f*
402.6898 485.348 m
412.2142 485.348 l
h
f*
203.4142 420.3213 m
212.9386 420.3213 l
h
f*
527.811 407.3386 m
537.3354 407.3386 l
h
f*
558.4252 394.2992 m
567.9496 394.2992 l
h
f*
435.6283 368.3339 m
445.1528 368.3339 l
h
f*
449.6315 368.3339 m
459.0992 368.3339 l
h
f*
538.1858 303.3071 m
547.6535 303.3071 l
h
f*
493.9087 264.3024 m
503.0362 264.3024 l
h
f*
411.9874 238.337 m
421.115 238.337 l
h
f*
425.3669 238.337 m
434.4945 238.337 l
h
f*
375.7039 199.3323 m
384.8315 199.3323 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9955 0 Td
(the)Tj
1.4684 0 Td
(need)Tj
2.143 0 Td
(of)Tj
1.0148 0 Td
(biological)Tj
4.0932 0 Td
(therapy)Tj
3.2428 0 Td
(and/or)Tj
2.9423 0 Td
(surgery)Tj
3.1918 0 Td
(in)Tj
1.0375 0 Td
(CD)Tj
1.6214 0 Td
(and)Tj
1.7291 0 Td
(could)Tj
2.4491 0 Td
(not)Tj
1.5761 0 Td
(reveal)Tj
2.5738 0 Td
(pro-)Tj
-35.3364 -1.3039 Td
(tective)Tj
2.8062 0 Td
(effect)Tj
2.3641 0 Td
(in)Tj
1.0375 0 Td
(UC.)Tj
-5.0116 -1.2982 Td
(According)Tj
4.439 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(results)Tj
2.8119 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(IBSEN)Tj
2.9197 0 Td
(cohort,)Tj
3.0841 0 Td
(45%)Tj
1.9275 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(CD)Tj
1.6214 0 Td
(patients)Tj
3.3675 0 Td
(were)Tj
2.1203 0 Td
(diagnosed)Tj
4.2803 0 Td
(with)Tj
-35.2287 -1.2983 Td
(colonic)Tj
3.1407 0 Td
(location)Tj
3.4526 0 Td
(and)Tj
1.7291 0 Td
(60.5%)Tj
2.6306 0 Td
(with)Tj
1.9955 0 Td
(non-stricturing,)Tj
6.599 0 Td
(non-penetrating)Tj
6.7748 0 Td
(behaviour)Tj
4.2349 0 Td
(at)Tj
0.9525 0 Td
(the)Tj
1.474 0 Td
(time)Tj
2.0239 0 Td
(of)Tj
-35.0076 -1.2983 Td
(diagnosis)Tj
3.9571 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
2.0749 0 Td
(In)Tj
1.1112 0 Td
(UC,)Tj
1.8425 0 Td
(the)Tj
1.474 0 Td
(initial)Tj
2.5455 0 Td
(extent)Tj
2.6759 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(disease)Tj
3.0161 0 Td
(was)Tj
1.7007 0 Td
(proctitis)Tj
3.5263 0 Td
(in)Tj
1.0375 0 Td
(32%,)Tj
2.1543 0 Td
(proctosigmoiditis)Tj
-29.6048 -1.3039 Td
(and)Tj
1.7291 0 Td
(left-sided)Tj
3.9344 0 Td
(colitis)Tj
2.5909 0 Td
(in)Tj
1.0318 0 Td
(35%)Tj
1.9332 0 Td
(and)Tj
1.7291 0 Td
(extensive)Tj
3.8835 0 Td
(colitis)Tj
2.5908 0 Td
(in)Tj
1.0375 0 Td
(33%)Tj
1.9275 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(].)Tj
2.075 0 Td
(In)Tj
1.1112 0 Td
(our)Tj
1.6214 0 Td
(study,)Tj
2.6192 0 Td
(the)Tj
1.4683 0 Td
(most)Tj
2.2053 0 Td
(common)Tj
-33.4882 -1.2982 Td
(locations)Tj
3.8097 0 Td
(and)Tj
1.7291 0 Td
(behaviour)Tj
4.2406 0 Td
(of)Tj
1.0148 0 Td
(CD)Tj
1.6214 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(distributions)Tj
5.3291 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(different)Tj
3.6567 0 Td
(extents)Tj
3.0387 0 Td
(of)Tj
1.0148 0 Td
(UC)Tj
1.6157 0 Td
(were)Tj
2.126 0 Td
(the)Tj
-34.8829 -1.2983 Td
(nearly)Tj
2.6985 0 Td
(the)Tj
1.4684 0 Td
(same.)Tj
2.4831 0 Td
(An)Tj
1.4513 0 Td
(Australian)Tj
4.3937 0 Td
(study)Tj
2.3924 0 Td
(of)Tj
1.0148 0 Td
(Niewiadomski)Tj
6.0094 0 Td
(O)Tj
0.9638 0 Td
(et)Tj
0.9411 0 Td
(al.)Tj
1.1282 0 Td
(established)Tj
4.5977 0 Td
(a)Tj
0.652 0 Td
(population-based)Tj
-30.1944 -1.3039 Td
(registry)Tj
3.2314 0 Td
(to)Tj
1.0262 0 Td
(assess)Tj
2.5228 0 Td
(disease)Tj
3.016 0 Td
(course)Tj
2.8347 0 Td
(in)Tj
1.0318 0 Td
(IBD)Tj
1.8765 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
2.0806 0 Td
(Immunomodulators)Tj
8.3792 0 Td
(were)Tj
2.1259 0 Td
(prescribed)Tj
4.4107 0 Td
(in)Tj
1.0375 0 Td
(57%)Tj
1.9275 0 Td
(of)Tj
-35.5008 -1.2983 Td
(CD)Tj
1.6157 0 Td
(patients,)Tj
3.5943 0 Td
(and)Tj
1.7348 0 Td
(19%)Tj
1.9275 0 Td
(with)Tj
1.9956 0 Td
(UC,)Tj
1.8425 0 Td
(steroids)Tj
3.3392 0 Td
(were)Tj
2.1203 0 Td
(used)Tj
2.0636 0 Td
(in)Tj
1.0318 0 Td
(74%)Tj
1.9332 0 Td
(of)Tj
1.0148 0 Td
(CD)Tj
1.6158 0 Td
(and)Tj
1.7291 0 Td
(63%)Tj
1.9332 0 Td
(of)Tj
1.0148 0 Td
(UC)Tj
1.6158 0 Td
(patients.)Tj
-32.122 -1.2983 Td
(Only)Tj
2.2166 0 Td
(13%)Tj
1.9276 0 Td
(of)Tj
1.0148 0 Td
(CD)Tj
1.6214 0 Td
(patients)Tj
3.3675 0 Td
(were)Tj
2.1203 0 Td
(started)Tj
2.9367 0 Td
(on)Tj
1.2756 0 Td
(biological)Tj
4.0875 0 Td
(therapy.)Tj
3.4696 0 Td
(In)Tj
1.1112 0 Td
(our)Tj
1.627 0 Td
(study,)Tj
2.6136 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
2.0296 0 Td
(half)Tj
1.7178 0 Td
(of)Tj
-35.4782 -1.3039 Td
(the)Tj
1.4569 0 Td
(patients)Tj
3.3619 0 Td
(received)Tj
3.5263 0 Td
(immunomodulators)Tj
8.2998 0 Td
(and)Tj
1.7234 0 Td
(more)Tj
2.3301 0 Td
(than)Tj
2.0183 0 Td
(one)Tj
1.6894 0 Td
(third)Tj
2.2053 0 Td
(of)Tj
1.0035 0 Td
(the)Tj
1.4627 0 Td
(patients)Tj
3.3618 0 Td
(received)Tj
3.5263 0 Td
(bio-)Tj
-35.9657 -1.2982 Td
(logical)Tj
2.8062 0 Td
(therapy)Tj
3.2485 0 Td
(during)Tj
2.9254 0 Td
(the)Tj
1.474 0 Td
(whole)Tj
2.6078 0 Td
(follow-up)Tj
4.0932 0 Td
(period.)Tj
3.0614 0 Td
(Use)Tj
1.7405 0 Td
(of)Tj
1.0148 0 Td
(thiopurine)Tj
4.473 0 Td
(was)Tj
1.7008 0 Td
(more)Tj
2.3414 0 Td
(common)Tj
3.8438 0 Td
(in)Tj
-35.3308 -1.2983 Td
(CD)Tj
1.6157 0 Td
(patients)Tj
3.3732 0 Td
(with)Tj
1.9956 0 Td
(colonic)Tj
3.1407 0 Td
(and)Tj
1.7292 0 Td
(ileocolonic)Tj
4.5864 0 Td
(locations.)Tj
4.0422 0 Td
(Use)Tj
1.7404 0 Td
(of)Tj
1.0148 0 Td
(methylprednisolone)Tj
8.2375 0 Td
(seems)Tj
2.6078 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
-35.1097 -1.3039 Td
(lower)Tj
2.4491 0 Td
(in)Tj
1.0374 0 Td
(our)Tj
1.6271 0 Td
(cohort,)Tj
3.0784 0 Td
(although)Tj
3.7531 0 Td
(it)Tj
0.788 0 Td
(also)Tj
1.7688 0 Td
(varies)Tj
2.5285 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(IBSEN)Tj
2.9197 0 Td
(studies-43%)Tj
5.0456 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(UC)Tj
1.6158 0 Td
(patients)Tj
3.3675 0 Td
(and)Tj
-34.9736 -1.2983 Td
(72%)Tj
1.9275 0 Td
(of)Tj
1.0148 0 Td
(CD)Tj
1.6214 0 Td
(patients)Tj
3.3675 0 Td
(had)Tj
1.7065 0 Td
(taken)Tj
2.4208 0 Td
(systemic)Tj
3.6283 0 Td
(glucocorticoids)Tj
6.3439 0 Td
(during)Tj
2.931 0 Td
(the)Tj
1.4683 0 Td
(5-year)Tj
2.7269 0 Td
(follow-up)Tj
4.0932 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7405 0 Td
(16)Tj
0 g
(].)Tj
-34.9906 -1.2982 Td
(In)Tj
1.1055 0 Td
(the)Tj
1.474 0 Td
(Australian)Tj
4.388 0 Td
(study,)Tj
2.6192 0 Td
(among)Tj
2.9933 0 Td
(CD)Tj
1.6158 0 Td
(patients,)Tj
3.5943 0 Td
(age)Tj
/F11 1 Tf
0 Tc
1.542 0 Td
(<)Tj
/F5 1 Tf
-0.004 Tc
0.9921 0 Td
(25)Tj
1.1736 0 Td
(years)Tj
2.262 0 Td
(at)Tj
0.9524 0 Td
(diagnosis,)Tj
4.1839 0 Td
(ileocolonic)Tj
4.5865 0 Td
(and)Tj
1.7291 0 Td
(peria-)Tj
-35.2117 -1.2983 Td
(nal)Tj
1.4456 0 Td
(disease)Tj
3.0217 0 Td
(were)Tj
2.1203 0 Td
(risk)Tj
1.7178 0 Td
(factors)Tj
2.9027 0 Td
(for)Tj
1.3833 0 Td
(biological)Tj
4.0932 0 Td
(therapy)Tj
3.2428 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
2.0806 0 Td
(In)Tj
1.1055 0 Td
(our)Tj
1.6271 0 Td
(cohort,)Tj
3.0784 0 Td
(no)Tj
1.2756 0 Td
(relationship)Tj
4.9889 0 Td
(was)Tj
-34.0835 -1.3039 Td
(found)Tj
2.6191 0 Td
(between)Tj
3.5263 0 Td
(location)Tj
3.4526 0 Td
(and)Tj
1.7291 0 Td
(behaviour)Tj
4.2406 0 Td
(of)Tj
1.0148 0 Td
(CD)Tj
1.6214 0 Td
(and)Tj
1.7292 0 Td
(disease)Tj
3.016 0 Td
(extent)Tj
2.6759 0 Td
(of)Tj
1.0148 0 Td
(UC)Tj
1.6214 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.474 0 Td
(use)Tj
1.5307 0 Td
(of)Tj
1.0148 0 Td
(biologi-)Tj
-34.0098 -1.2983 Td
(cal)Tj
1.3209 0 Td
(therapy,)Tj
3.4752 0 Td
(however)Tj
3.6114 0 Td
(need)Tj
2.1429 0 Td
(of)Tj
1.0148 0 Td
(biologicals)Tj
4.4504 0 Td
(was)Tj
1.7008 0 Td
(more)Tj
2.3414 0 Td
(common)Tj
3.8437 0 Td
(in)Tj
1.0375 0 Td
(patients)Tj
3.3675 0 Td
(below)Tj
2.5852 0 Td
(the)Tj
1.4684 0 Td
(age)Tj
1.5477 0 Td
(of)Tj
1.0148 0 Td
(40)Tj
-34.9226 -1.2983 Td
(years)Tj
2.262 0 Td
(and)Tj
1.7291 0 Td
(in)Tj
1.0375 0 Td
(UC)Tj
1.6214 0 Td
(patients)Tj
3.3675 0 Td
(with)Tj
1.9956 0 Td
(more)Tj
2.3414 0 Td
(severe)Tj
2.6759 0 Td
(initial)Tj
2.5512 0 Td
(disease)Tj
3.016 0 Td
(activity.)Tj
-21.4014 -1.3039 Td
(In)Tj
1.1111 0 Td
(the)Tj
1.4684 0 Td
(IBSEN)Tj
2.9253 0 Td
(cohort,)Tj
3.0784 0 Td
(28%)Tj
1.9276 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(CD)Tj
1.6214 0 Td
(patients)Tj
3.3675 0 Td
(underwent)Tj
4.5751 0 Td
(surgery)Tj
3.1918 0 Td
(with)Tj
2.0013 0 Td
(intestinal)Tj
3.9118 0 Td
(resection)Tj
-32.859 -1.2982 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
2.0749 0 Td
(Intestinal)Tj
3.9855 0 Td
(resection)Tj
3.8437 0 Td
(rates)Tj
2.109 0 Td
(were)Tj
2.1203 0 Td
(26%)Tj
1.9332 0 Td
(at)Tj
0.9468 0 Td
(5)Tj
0.6973 0 Td
(years)Tj
2.2677 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(study)Tj
2.3868 0 Td
(of)Tj
1.0148 0 Td
(Niewiadomski)Tj
6.0094 0 Td
(et)Tj
0.9411 0 Td
(al.)Tj
1.1282 0 Td
(Risk)Tj
1.9672 0 Td
(fac-)Tj
-35.9317 -1.2983 Td
(tors)Tj
1.7574 0 Td
(of)Tj
1.0148 0 Td
(surgery)Tj
3.1918 0 Td
(included)Tj
3.7134 0 Td
(penetrating)Tj
4.8188 0 Td
(and)Tj
1.7292 0 Td
(stricturing)Tj
4.4163 0 Td
(disease)Tj
3.0217 0 Td
(and)Tj
1.7291 0 Td
(ileal)Tj
1.8369 0 Td
(involvement)Tj
5.21 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
2.0806 0 Td
(Colect-)Tj
-34.52 -1.3039 Td
(omy)Tj
2.0012 0 Td
(rate)Tj
1.7461 0 Td
(in)Tj
1.0375 0 Td
(UC)Tj
1.6157 0 Td
(was)Tj
1.7008 0 Td
(13%)Tj
1.9276 0 Td
(at)Tj
0.9524 0 Td
(5)Tj
0.6973 0 Td
(years)Tj
2.262 0 Td
(with)Tj
2.0013 0 Td
(high)Tj
2.0069 0 Td
(CRP)Tj
2.0636 0 Td
(at)Tj
0.9525 0 Td
(diagnosis)Tj
3.9571 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(colectomy)Tj
4.3256 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
-35.5008 -1.2983 Td
(According)Tj
4.439 0 Td
(to)Tj
1.0204 0 Td
(the)Tj
1.474 0 Td
(data)Tj
1.9106 0 Td
(of)Tj
1.0148 0 Td
(UC)Tj
1.6214 0 Td
(patients)Tj
3.3675 0 Td
(from)Tj
2.2054 0 Td
(IBSEN)Tj
2.9196 0 Td
(studies,)Tj
3.2145 0 Td
(overall)Tj
2.9027 0 Td
(colectomy)Tj
4.3256 0 Td
(rate)Tj
1.7461 0 Td
(proved)Tj
3.0218 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
-36.2095 -1.2983 Td
(7.5%)Tj
2.1543 0 Td
(and)Tj
1.7291 0 Td
(9.8%)Tj
2.1543 0 Td
(during)Tj
2.9253 0 Td
(the)Tj
1.4684 0 Td
(5)Tj
0.6973 0 Td
(and)Tj
1.7291 0 Td
(10-year)Tj
3.2088 0 Td
(follow)Tj
2.6986 0 Td
(up)Tj
1.2642 0 Td
(periods)Tj
3.1918 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7405 0 Td
(18)Tj
0 g
(].)Tj
1.7348 0 Td
(Initial)Tj
2.6192 0 Td
(presentation)Tj
5.2214 0 Td
(includ-)Tj
-34.5371 -1.2982 Td
(ing)Tj
1.5023 0 Td
(extensive)Tj
3.8834 0 Td
(colitis,)Tj
2.812 0 Td
(elevated)Tj
3.4526 0 Td
(ESR,)Tj
2.1146 0 Td
(anaemia)Tj
3.5773 0 Td
(and)Tj
1.7348 0 Td
(fever)Tj
2.177 0 Td
(was)Tj
1.7008 0 Td
(significantly)Tj
5.091 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9955 0 Td
(an)Tj
-34.2989 -1.3039 Td
(increased)Tj
3.9968 0 Td
(risk)Tj
1.7178 0 Td
(and)Tj
1.7291 0 Td
(age)Tj
/F13 1 Tf
0 Tc
1.542 0 Td
()Tj
/F5 1 Tf
-0.004 Tc
(50)Tj
1.9446 0 Td
(years)Tj
2.262 0 Td
(with)Tj
2.0013 0 Td
(a)Tj
0.6519 0 Td
(reduced)Tj
3.4469 0 Td
(risk)Tj
1.7121 0 Td
(of)Tj
1.0148 0 Td
(subsequent)Tj
4.7055 0 Td
(colectomy.)Tj
4.5524 0 Td
(In)Tj
1.1055 0 Td
(our)Tj
1.6271 0 Td
(cohort)Tj
-34.0098 -1.2983 Td
(we)Tj
1.3266 0 Td
(found)Tj
2.6192 0 Td
(lower)Tj
2.4491 0 Td
(rate)Tj
1.7518 0 Td
(of)Tj
1.0148 0 Td
(surgery)Tj
3.1918 0 Td
(in)Tj
1.0374 0 Td
(patients)Tj
3.3676 0 Td
(treated)Tj
2.999 0 Td
(with)Tj
1.9956 0 Td
(thiopurines.)Tj
5.0626 0 Td
(In)Tj
1.1055 0 Td
(CD,)Tj
1.8482 0 Td
(ileal)Tj
1.8369 0 Td
(location)Tj
3.4525 0 Td
(and)Tj
-35.0586 -1.2983 Td
(penetrating)Tj
4.8131 0 Td
(behaviour,)Tj
4.4674 0 Td
(in)Tj
1.0375 0 Td
(UC,)Tj
1.8425 0 Td
(more)Tj
2.3414 0 Td
(severe)Tj
2.6759 0 Td
(initial)Tj
2.5512 0 Td
(disease)Tj
3.016 0 Td
(activity)Tj
3.1181 0 Td
(\(assessed)Tj
3.8154 0 Td
(by)Tj
1.1792 0 Td
(high)Tj
2.0069 0 Td
(CRP)Tj
2.0636 0 Td
(and)Tj
-34.9282 -1.3039 Td
(pMayo)Tj
3.0217 0 Td
(score\))Tj
2.6475 0 Td
(and)Tj
1.7291 0 Td
(in)Tj
1.0375 0 Td
(both)Tj
2.0579 0 Td
(diseases)Tj
3.3789 0 Td
(age)Tj
1.5477 0 Td
(above)Tj
2.5455 0 Td
(40)Tj
1.1679 0 Td
(years)Tj
2.2677 0 Td
(at)Tj
0.9524 0 Td
(diagnosis)Tj
3.9572 0 Td
(related)Tj
2.9423 0 Td
(to)Tj
1.0261 0 Td
(surgery)Tj
3.1975 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(].)Tj
-32.2807 -1.2982 Td
(The)Tj
-0.024 Tc
1.7858 0 Td
(systematic)Tj
4.1612 0 Td
(review)Tj
2.7213 0 Td
(and)Tj
1.6724 0 Td
(meta-analysis)Tj
5.3914 0 Td
(of)Tj
0.9752 0 Td
(Dias)Tj
1.9388 0 Td
(et)Tj
0.9015 0 Td
(al.)Tj
1.0658 0 Td
(highlights)Tj
3.9741 0 Td
(that)Tj
1.7008 0 Td
(delay)Tj
2.2053 0 Td
(in)Tj
0.9922 0 Td
(diagnosis)Tj
3.7814 0 Td
(is)Tj
0.805 0 Td
(a)Tj
-35.2684 -1.2983 Td
(crucial)Tj
2.7722 0 Td
(factor)Tj
2.4208 0 Td
(for)Tj
1.3266 0 Td
(unfavourable)Tj
5.2497 0 Td
(disease)Tj
2.88 0 Td
(outcome)Tj
3.583 0 Td
(in)Tj
0.9978 0 Td
(IBD,)Tj
2.0239 0 Td
(since)Tj
2.143 0 Td
(due)Tj
1.6384 0 Td
(to)Tj
0.9864 0 Td
(delays)Tj
2.5455 0 Td
(in)Tj
0.9978 0 Td
(diagnosis,)Tj
3.9798 0 Td
(disease)Tj
-33.5449 -1.3039 Td
(activity)Tj
2.9593 0 Td
(and)Tj
1.6668 0 Td
(bowel)Tj
2.4888 0 Td
(damage)Tj
3.2031 0 Td
(start)Tj
1.8822 0 Td
(to)Tj
0.9864 0 Td
(worsen)Tj
2.9934 0 Td
(in)Tj
0.9978 0 Td
(the)Tj
1.4116 0 Td
(lack)Tj
1.7405 0 Td
(of)Tj
0.9751 0 Td
(appropriate)Tj
4.6545 0 Td
(therapy)Tj
3.1067 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(].)Tj
1.9786 0 Td
(A)Tj
0.8844 0 Td
(delay)Tj
2.2053 0 Td
(in)Tj
-34.1345 -1.2983 Td
(confirming)Tj
4.524 0 Td
(the)Tj
1.4117 0 Td
(diagnosis)Tj
3.7757 0 Td
(of)Tj
0.9751 0 Td
(IBD)Tj
1.8198 0 Td
(is)Tj
0.8051 0 Td
(associated)Tj
4.0591 0 Td
(with)Tj
1.9163 0 Td
(increased)Tj
3.821 0 Td
(need)Tj
2.0636 0 Td
(for)Tj
1.3267 0 Td
(surgery,)Tj
3.2598 0 Td
(poorer)Tj
2.7949 0 Td
(treatment)Tj
-32.5528 -1.2983 Td
(outcomes,)Tj
4.1328 0 Td
(reduced)Tj
3.3052 0 Td
(quality)Tj
2.812 0 Td
(of)Tj
0.9751 0 Td
(life,)Tj
1.5704 0 Td
(and)Tj
1.6724 0 Td
(extent)Tj
2.5568 0 Td
(of)Tj
0.9751 0 Td
(disease)Tj
2.88 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.6554 0 Td
(21)Tj
0 g
(].)Tj
1.6555 0 Td
(A)Tj
0.8844 0 Td
(French)Tj
2.9253 0 Td
(study)Tj
2.2847 0 Td
(revealed)Tj
3.3676 0 Td
(that)Tj
1.7007 0 Td
(diag-)Tj
-35.3534 -1.3039 Td
(nostic)Tj
2.4944 0 Td
(delay)Tj
2.1997 0 Td
(more)Tj
2.2507 0 Td
(than)Tj
1.9445 0 Td
(12)Tj
1.1226 0 Td
(months)Tj
3.1521 0 Td
(is)Tj
0.7993 0 Td
(associated)Tj
4.0479 0 Td
(with)Tj
1.9105 0 Td
(the)Tj
1.4003 0 Td
(presence)Tj
3.549 0 Td
(of)Tj
0.9637 0 Td
(disease)Tj
2.8687 0 Td
(complications,)Tj
5.777 0 Td
(suggest-)Tj
-34.4804 -1.2982 Td
(ing)Tj
1.4399 0 Td
(that)Tj
1.7008 0 Td
(a)Tj
0.6293 0 Td
(delay)Tj
2.211 0 Td
(in)Tj
0.9921 0 Td
(diagnosis)Tj
3.7814 0 Td
(beyond)Tj
3.0671 0 Td
(12)Tj
1.1282 0 Td
(months)Tj
3.1634 0 Td
(may)Tj
1.8709 0 Td
(result)Tj
2.3244 0 Td
(in)Tj
0.9978 0 Td
(missing)Tj
3.1691 0 Td
(the)Tj
1.4116 0 Td
(therapeutic)Tj
4.5127 0 Td
(window)Tj
3.3166 0 Td
(to)Tj
-35.7163 -1.2983 Td
(intervene)Tj
3.7984 0 Td
(before)Tj
2.6191 0 Td
(disease)Tj
2.88 0 Td
(complications)Tj
5.5786 0 Td
(occur)Tj
2.3754 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(].)Tj
1.9729 0 Td
(Our)Tj
1.8085 0 Td
(results)Tj
2.6702 0 Td
(also)Tj
1.6838 0 Td
(suggest)Tj
2.982 0 Td
(that)Tj
1.7008 0 Td
(more)Tj
2.262 0 Td
(than)Tj
1.9502 0 Td
(1)Tj
0.6747 0 Td
(year)Tj
-34.9566 -1.2983 Td
(diagnostic)Tj
4.1158 0 Td
(delay)Tj
2.211 0 Td
(may)Tj
1.8652 0 Td
(relate)Tj
2.2961 0 Td
(to)Tj
0.9864 0 Td
(higher)Tj
2.6816 0 Td
(risk)Tj
1.6384 0 Td
(of)Tj
0.9751 0 Td
(surgery)Tj
3.0557 0 Td
(and)Tj
1.6668 0 Td
(need)Tj
2.0636 0 Td
(of)Tj
0.9751 0 Td
(biological)Tj
3.8891 0 Td
(therapy)Tj
3.1068 0 Td
(in)Tj
0.9978 0 Td
(CD)Tj
1.5817 0 Td
(and)Tj
1.6668 0 Td
(UC.)Tj
-0.004 Tc
-34.5768 -1.3039 Td
(The)Tj
1.7858 0 Td
(major)Tj
2.6078 0 Td
(strength)Tj
3.515 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(present)Tj
3.1635 0 Td
(study)Tj
2.3924 0 Td
(is)Tj
0.8447 0 Td
(the)Tj
1.4683 0 Td
(prospective)Tj
4.7849 0 Td
(inclusion)Tj
3.9174 0 Td
(and)Tj
1.7292 0 Td
(follow-up)Tj
4.0988 0 Td
(of)Tj
1.0148 0 Td
(inci-)Tj
-35.0019 -1.2983 Td
(dent)Tj
2.0182 0 Td
(IBD)Tj
1.8765 0 Td
(patients)Tj
3.3676 0 Td
(diagnosed)Tj
4.2803 0 Td
(in)Tj
1.0374 0 Td
(one)Tj
1.6951 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(largest)Tj
2.8177 0 Td
(IBD)Tj
1.8765 0 Td
(center)Tj
2.7099 0 Td
(of)Tj
1.0148 0 Td
(Hungary.)Tj
4.0138 0 Td
(The)Tj
1.7802 0 Td
(relatively)Tj
3.8437 0 Td
(high)Tj
-34.8205 -1.2982 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(patients)Tj
3.3675 0 Td
(represents)Tj
4.32 0 Td
(correctly)Tj
3.7361 0 Td
(the)Tj
1.4683 0 Td
(Hungarian)Tj
4.5864 0 Td
(IBD)Tj
1.8765 0 Td
(population.)Tj
4.8132 0 Td
(The)Tj
1.7859 0 Td
(patients)Tj
3.3675 0 Td
(are)Tj
1.4457 0 Td
(unse-)Tj
-35.2004 -1.3039 Td
(lected)Tj
2.5625 0 Td
(and)Tj
1.7291 0 Td
(represent)Tj
3.9571 0 Td
(the)Tj
1.4684 0 Td
(whole)Tj
2.6135 0 Td
(spectrum)Tj
3.9628 0 Td
(of)Tj
1.0148 0 Td
(disease)Tj
3.016 0 Td
(severity.)Tj
3.498 0 Td
(Additionally,)Tj
5.4538 0 Td
(this)Tj
1.6724 0 Td
(study)Tj
2.3924 0 Td
(character-)Tj
-33.3408 -1.2983 Td
(ized)Tj
1.8481 0 Td
(a)Tj
0.6577 0 Td
(long)Tj
1.9842 0 Td
(follow-up)Tj
4.0932 0 Td
(period)Tj
2.8346 0 Td
(of)Tj
1.0148 0 Td
(both)Tj
2.0636 0 Td
(CU)Tj
1.6158 0 Td
(and)Tj
1.7291 0 Td
(CD)Tj
1.6214 0 Td
(patients)Tj
3.3675 0 Td
(However,)Tj
4.0762 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6577 0 Td
(limitation,)Tj
4.3993 0 Td
(there)Tj
2.262 0 Td
(were)Tj
-35.24 -1.2983 Td
(cases)Tj
2.2223 0 Td
(in)Tj
1.0375 0 Td
(which)Tj
2.6475 0 Td
(we)Tj
1.3266 0 Td
(were)Tj
2.126 0 Td
(not)Tj
1.5704 0 Td
(able)Tj
1.8311 0 Td
(to)Tj
1.0262 0 Td
(perform)Tj
3.5149 0 Td
(a)Tj
0.6577 0 Td
(complete)Tj
3.8777 0 Td
(follow-up)Tj
4.0932 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(medical)Tj
3.3618 0 Td
(records.)Tj
3.4299 0 Td
(After)Tj
-35.206 -1.3039 Td
(excluding)Tj
4.1158 0 Td
(these)Tj
2.2507 0 Td
(data)Tj
1.9162 0 Td
(from)Tj
2.2054 0 Td
(statistical)Tj
3.9061 0 Td
(analysis,)Tj
3.5546 0 Td
(no)Tj
1.2756 0 Td
(significant)Tj
4.388 0 Td
(difference)Tj
4.2066 0 Td
(remained)Tj
4.0308 0 Td
(regarding)Tj
4.0932 0 Td
(the)Tj
-35.943 -1.2982 Td
(median)Tj
3.2371 0 Td
(lag)Tj
1.3663 0 Td
(time)Tj
2.0296 0 Td
(between)Tj
3.5263 0 Td
(onset)Tj
2.3584 0 Td
(of)Tj
1.0148 0 Td
(symptoms)Tj
4.3596 0 Td
(and)Tj
1.7291 0 Td
(diagnosis.)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 417.3165 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Disease)Tj
3.7701 0 Td
(outcome)Tj
3.9968 0 Td
(in)Tj
0.978 0 Td
(IBD)Tj
1.8638 0 Td
(in)Tj
0.978 0 Td
(a)Tj
0.7653 0 Td
(Hungarian)Tj
4.7481 0 Td
(center)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.02008)Tj
4.089 0 Td
(24)Tj
0 g
2.0906 0 Td
(July)Tj
1.9701 0 Td
(30,)Tj
1.5874 0 Td
(2018)Tj
35.894 0 Td
(6)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
109 0 obj
<>stream
endstream
endobj
110 0 obj
<>stream
endstream
endobj
111 0 obj
<>stream
endstream
endobj
112 0 obj
<>stream
endstream
endobj
113 0 obj
<>stream
endstream
endobj
114 0 obj
<>stream
endstream
endobj
115 0 obj
<>stream
endstream
endobj
116 0 obj
<>stream
BT
66.9477 0 Td
(8)Tj
ET
Q
endstream
endobj
117 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 118 0 R/Contents 119 0 R/TrimBox[0 0 612 792]>>
endobj
118 0 obj
[120 0 R 121 0 R 122 0 R 123 0 R 124 0 R 125 0 R 126 0 R 127 0 R 128 0 R 129 0 R 130 0 R 131 0 R 132 0 R 133 0 R 134 0 R 135 0 R 136 0 R 137 0 R 138 0 R 139 0 R]
endobj
120 0 obj
<>/Border[0 0 0]/A 140 0 R>>
endobj
140 0 obj
<>
endobj
121 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref001)>>
endobj
122 0 obj
<>/Border[0 0 0]/A 141 0 R>>
endobj
141 0 obj
<>
endobj
123 0 obj
<>/Border[0 0 0]/A 142 0 R>>
endobj
142 0 obj
<>
endobj
124 0 obj
<>/Border[0 0 0]/A 143 0 R>>
endobj
143 0 obj
<>
endobj
125 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref002)>>
endobj
126 0 obj
<>/Border[0 0 0]/A 144 0 R>>
endobj
144 0 obj
<>
endobj
127 0 obj
<>/Border[0 0 0]/A 145 0 R>>
endobj
145 0 obj
<>
endobj
128 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref003)>>
endobj
129 0 obj
<>/Border[0 0 0]/A 146 0 R>>
endobj
146 0 obj
<>
endobj
130 0 obj
<>/Border[0 0 0]/A 147 0 R>>
endobj
147 0 obj
<>
endobj
131 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref004)>>
endobj
132 0 obj
<>/Border[0 0 0]/A 148 0 R>>
endobj
148 0 obj
<>
endobj
133 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref005)>>
endobj
134 0 obj
<>/Border[0 0 0]/A 149 0 R>>
endobj
149 0 obj
<>
endobj
135 0 obj
<>/Border[0 0 0]/A 150 0 R>>
endobj
150 0 obj
<>
endobj
136 0 obj
<>/Border[0 0 0]/A 151 0 R>>
endobj
151 0 obj
<>
endobj
137 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref006)>>
endobj
138 0 obj
<>/Border[0 0 0]/A 152 0 R>>
endobj
152 0 obj
<>
endobj
139 0 obj
<>/Border[0 0 0]/A 153 0 R>>
endobj
153 0 obj
<>
endobj
119 0 obj
[154 0 R 155 0 R 156 0 R 157 0 R 158 0 R 159 0 R 160 0 R 161 0 R 162 0 R]
endobj
154 0 obj
<>stream
q
0.83 0.64 0.02 0 k
452.1827 222.9165 m
556.6677 222.9165 l
h
f*
221.4992 213.4488 m
288.7937 213.4488 l
h
f*
314.2488 213.4488 m
349.2283 213.4488 l
h
f*
253.8142 190.9417 m
423.0992 190.9417 l
h
f*
448.5543 190.9417 m
483.5339 190.9417 l
h
f*
380.5228 168.4346 m
534.3874 168.4346 l
h
f*
221.4992 158.9102 m
256.422 158.9102 l
h
f*
279.326 136.4031 m
309.9402 136.4031 l
h
f*
489.4299 113.8961 m
569.9339 113.8961 l
h
f*
221.4992 104.4283 m
280.5165 104.4283 l
h
f*
305.9717 104.4283 m
340.8945 104.4283 l
h
f*
533.1969 81.9213 m
563.7543 81.9213 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 211.9748 707.4141 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(In)Tj
1.1111 0 Td
(this)Tj
1.6725 0 Td
(study)Tj
2.3924 0 Td
(we)Tj
1.3266 0 Td
(used)Tj
2.0579 0 Td
(objective)Tj
3.7814 0 Td
(measures,)Tj
4.1669 0 Td
(surgery)Tj
3.1975 0 Td
(and)Tj
1.7291 0 Td
(need)Tj
2.143 0 Td
(of)Tj
1.0148 0 Td
(biological)Tj
4.0932 0 Td
(therapy)Tj
3.2428 0 Td
(as)Tj
1.0148 0 Td
(surro-)Tj
-34.1402 -1.3039 Td
(gate)Tj
1.8424 0 Td
(markers)Tj
3.4923 0 Td
(of)Tj
1.0148 0 Td
(worse)Tj
2.5682 0 Td
(disease)Tj
3.016 0 Td
(course.)Tj
3.0614 0 Td
(Our)Tj
1.8652 0 Td
(follow-up)Tj
4.0932 0 Td
(study)Tj
2.3924 0 Td
(on)Tj
1.2756 0 Td
(almost)Tj
2.8857 0 Td
(1000)Tj
2.1203 0 Td
(IBD)Tj
1.8765 0 Td
(patients)Tj
-31.504 -1.2982 Td
(revealed)Tj
3.5205 0 Td
(that)Tj
1.7802 0 Td
(at)Tj
0.9524 0 Td
(diagnosis)Tj
3.9572 0 Td
(of)Tj
1.0148 0 Td
(IBD)Tj
1.8765 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.6519 0 Td
(referral)Tj
3.1521 0 Td
(center,)Tj
2.931 0 Td
(factors)Tj
2.9027 0 Td
(predictive)Tj
4.1952 0 Td
(of)Tj
1.0148 0 Td
(surgery)Tj
3.1975 0 Td
(were)Tj
2.1203 0 Td
(age)Tj
-34.3046 -1.2983 Td
(below)Tj
2.5851 0 Td
(40,)Tj
1.4003 0 Td
(although)Tj
3.7531 0 Td
(age)Tj
1.542 0 Td
(above)Tj
2.5455 0 Td
(40)Tj
1.1679 0 Td
(years)Tj
2.2677 0 Td
(proved)Tj
3.0217 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(protective)Tj
4.2009 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.474 0 Td
(need)Tj
2.143 0 Td
(of)Tj
1.0148 0 Td
(biologicals)Tj
4.4503 0 Td
(in)Tj
-35.0189 -1.2983 Td
(both)Tj
2.0579 0 Td
(diseases)Tj
3.3789 0 Td
(as)Tj
1.0147 0 Td
(well)Tj
1.8199 0 Td
(as)Tj
1.0148 0 Td
(use)Tj
1.5307 0 Td
(of)Tj
1.0148 0 Td
(oral)Tj
1.7801 0 Td
(contraceptives.)Tj
6.1965 0 Td
(However,)Tj
4.0762 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
2.0296 0 Td
(1)Tj
0.6973 0 Td
(year)Tj
1.9049 0 Td
(of)Tj
1.0148 0 Td
(diagnostic)Tj
-31.8725 -1.3039 Td
(delay,)Tj
2.5284 0 Td
(disease)Tj
3.0217 0 Td
(activity)Tj
3.1181 0 Td
(at)Tj
0.9525 0 Td
(diagnosis)Tj
3.9571 0 Td
(in)Tj
1.0318 0 Td
(UC,)Tj
1.8482 0 Td
(CD,)Tj
1.8425 0 Td
(ileal)Tj
1.8368 0 Td
(location)Tj
3.4526 0 Td
(and)Tj
1.7291 0 Td
(penetrating)Tj
4.8189 0 Td
(behaviour)Tj
4.2406 0 Td
(seems)Tj
-34.3783 -1.2982 Td
(also)Tj
1.7687 0 Td
(to)Tj
1.0205 0 Td
(be)Tj
1.1509 0 Td
(important)Tj
4.2859 0 Td
(factors)Tj
2.9027 0 Td
(that)Tj
1.7745 0 Td
(may)Tj
1.9332 0 Td
(influence)Tj
3.9118 0 Td
(disease)Tj
3.0217 0 Td
(outcome.)Tj
3.9514 0 Td
(Use)Tj
1.7405 0 Td
(of)Tj
1.0148 0 Td
(thiopurines)Tj
4.8359 0 Td
(seemed)Tj
3.1974 0 Td
(to)Tj
-36.5099 -1.2983 Td
(be)Tj
1.1509 0 Td
(protective)Tj
4.2008 0 Td
(in)Tj
1.0375 0 Td
(UC.)Tj
-5.193 -1.3039 Td
(Improvement)Tj
5.7486 0 Td
(of)Tj
1.0148 0 Td
(treatment)Tj
4.1329 0 Td
(strategies)Tj
3.9231 0 Td
(to)Tj
1.0261 0 Td
(minimize)Tj
4.0479 0 Td
(structural)Tj
4.0762 0 Td
(bowel)Tj
2.5908 0 Td
(damage)Tj
3.3222 0 Td
(and)Tj
1.7291 0 Td
(complica-)Tj
-32.8079 -1.2983 Td
(tions)Tj
2.1996 0 Td
(of)Tj
1.0148 0 Td
(disease)Tj
3.016 0 Td
(has)Tj
1.5478 0 Td
(an)Tj
1.2018 0 Td
(increasing)Tj
4.3257 0 Td
(role)Tj
1.7688 0 Td
(in)Tj
1.0375 0 Td
(IBD.)Tj
2.1033 0 Td
(Hopefully)Tj
4.1952 0 Td
(the)Tj
1.4683 0 Td
(new)Tj
1.8766 0 Td
(trends)Tj
2.7496 0 Td
(in)Tj
1.0374 0 Td
(IBD)Tj
1.8766 0 Td
(management)Tj
-31.419 -1.2983 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(optimization)Tj
5.3631 0 Td
(of)Tj
1.0148 0 Td
(therapeutic)Tj
4.7338 0 Td
(options,)Tj
3.4526 0 Td
(combined)Tj
4.2463 0 Td
(with)Tj
1.9956 0 Td
(new)Tj
1.8765 0 Td
(drugs,)Tj
2.6986 0 Td
(will)Tj
1.661 0 Td
(make)Tj
2.3925 0 Td
(possible)Tj
3.4129 0 Td
(to)Tj
-36.0451 -1.3039 Td
(change)Tj
3.0387 0 Td
(the)Tj
1.4683 0 Td
(course)Tj
2.829 0 Td
(of)Tj
1.0148 0 Td
(disease)Tj
3.016 0 Td
(and)Tj
1.7291 0 Td
(provide)Tj
3.2882 0 Td
(better)Tj
2.5398 0 Td
(therapy)Tj
3.2428 0 Td
(and)Tj
1.7291 0 Td
(quality)Tj
2.9537 0 Td
(of)Tj
1.0092 0 Td
(life)Tj
1.4456 0 Td
(for)Tj
1.3833 0 Td
(patients)Tj
3.3676 0 Td
(suffering)Tj
-34.0552 -1.2982 Td
(from)Tj
2.2053 0 Td
(IBD.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 524.2393 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Supporting)Tj
5.537 0 Td
(information)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 507.2881 cm
BT
/F10 1 Tf
1 TL
-0.004 Tc
0 0 Td
(S1)Tj
1.2132 0 Td
(Table.)Tj
2.8119 0 Td
(Demographic)Tj
5.9301 0 Td
(and)Tj
1.7914 0 Td
(clinical)Tj
3.2259 0 Td
(characteristics)Tj
6.2248 0 Td
(of)Tj
1.0715 0 Td
(the)Tj
1.542 0 Td
(enrolled)Tj
3.668 0 Td
(patients.)Tj
/F5 1 Tf
3.8211 0 Td
(There)Tj
2.5795 0 Td
(is)Tj
0.8504 0 Td
(no)Tj
-34.7298 -1.3039 Td
(potentially)Tj
4.4617 0 Td
(identifying)Tj
4.575 0 Td
(information)Tj
5.074 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(supporting)Tj
4.6035 0 Td
(information)Tj
5.074 0 Td
(file.)Tj
-26.294 -1.2982 Td
(\(XLSX\))Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 448.1574 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Author)Tj
3.4771 0 Td
(Contributions)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 431.1496 cm
BT
/F10 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Conceptualization:)Tj
/F5 1 Tf
8.1523 0 Td
(Zolta)Tj
0 Tc
1.6781 0.051 Td
()Tj
-0.004 Tc
0.4082 -0.051 Td
(n)Tj
0.771 0 Td
(Szepes,)Tj
3.0614 0 Td
(Ferenc)Tj
2.9367 0 Td
(Nagy,)Tj
2.5342 0 Td
(Tama)Tj
0 Tc
1.8878 0.051 Td
()Tj
-0.004 Tc
0.4082 -0.051 Td
(s)Tj
0.584 0 Td
(Molna)Tj
0 Tc
2.2166 0.051 Td
()Tj
-0.004 Tc
0.4139 -0.051 Td
(r,)Tj
0.8164 0 Td
(Klaudia)Tj
3.3278 0 Td
(Farkas.)Tj
/F10 1 Tf
-29.1966 -1.8028 Td
(Data)Tj
2.245 0 Td
(curation:)Tj
/F5 1 Tf
4.0138 0 Td
(Kata)Tj
2.0579 0 Td
(Sza)Tj
0 Tc
0.9128 0.0511 Td
()Tj
-0.004 Tc
0.4082 -0.0511 Td
(nto)Tj
0 Tc
0.9127 0.0511 Td
()Tj
-0.004 Tc
0.4422 -0.0511 Td
(,)Tj
0.4479 0 Td
(Anita)Tj
2.4491 0 Td
(Ba)Tj
0 Tc
0.601 0.0511 Td
()Tj
-0.004 Tc
0.4138 -0.0511 Td
(lint,)Tj
1.8085 0 Td
(Mariann)Tj
3.7134 0 Td
(Rutka,)Tj
2.8233 0 Td
(Klaudia)Tj
3.3278 0 Td
(Farkas.)Tj
/F10 1 Tf
-26.5774 -1.7971 Td
(Formal)Tj
3.2711 0 Td
(analysis:)Tj
/F5 1 Tf
3.7474 0 Td
(Tibor)Tj
2.4831 0 Td
(Nya)Tj
0 Tc
1.2132 0.051 Td
()Tj
-0.004 Tc
0.4139 -0.051 Td
(ri.)Tj
/F10 1 Tf
-11.1287 -1.8029 Td
(Investigation:)Tj
/F5 1 Tf
5.9583 0 Td
(Anita)Tj
2.4548 0 Td
(Ba)Tj
0 Tc
0.601 0.0511 Td
()Tj
-0.004 Tc
0.4138 -0.0511 Td
(lint,)Tj
1.8028 0 Td
(Rena)Tj
0 Tc
1.6158 0.0511 Td
()Tj
-0.004 Tc
0.4138 -0.0511 Td
(ta)Tj
0.9525 0 Td
(Bor,)Tj
1.9048 0 Td
(A)Tj
0 Tc
0.1418 0.2608 Td
()Tj
-0.004 Tc
0.5386 -0.2608 Td
(gnes)Tj
2.0182 0 Td
(Milassin,)Tj
3.8211 0 Td
(Mariann)Tj
3.719 0 Td
(Rutka,)Tj
2.8233 0 Td
(Anna)Tj
2.4378 0 Td
(Fa)Tj
0 Tc
0.5499 0.0511 Td
()Tj
-0.004 Tc
0.4082 -0.0511 Td
(bia)Tj
0 Tc
0.7994 0.0511 Td
()Tj
-0.004 Tc
0.4081 -0.0511 Td
(n,)Tj
0.9978 0 Td
(Klau-)Tj
-33.5846 -1.2982 Td
(dia)Tj
1.4513 0 Td
(Farkas.)Tj
/F10 1 Tf
-2.6475 -1.8028 Td
(Methodology:)Tj
/F5 1 Tf
5.998 0 Td
(Anita)Tj
2.4548 0 Td
(Ba)Tj
0 Tc
0.601 0.0567 Td
()Tj
-0.004 Tc
0.4138 -0.0567 Td
(lint,)Tj
1.8028 0 Td
(Rena)Tj
0 Tc
1.6158 0.0567 Td
()Tj
-0.004 Tc
0.4138 -0.0567 Td
(ta)Tj
0.9525 0 Td
(Bor,)Tj
1.8992 0 Td
(A)Tj
0 Tc
0.1474 0.2608 Td
()Tj
-0.004 Tc
0.5385 -0.2608 Td
(gnes)Tj
2.0183 0 Td
(Milassin,)Tj
3.8211 0 Td
(Mariann)Tj
3.719 0 Td
(Rutka,)Tj
2.8233 0 Td
(Anna)Tj
2.4378 0 Td
(Fa)Tj
0 Tc
0.5442 0.0567 Td
()Tj
-0.004 Tc
0.4139 -0.0567 Td
(bia)Tj
0 Tc
0.7993 0.0567 Td
()Tj
-0.004 Tc
0.4082 -0.0567 Td
(n.)Tj
/F10 1 Tf
-33.8227 -1.7972 Td
(Project)Tj
3.2258 0 Td
(administration:)Tj
/F5 1 Tf
6.7464 0 Td
(Kata)Tj
2.0636 0 Td
(Sza)Tj
0 Tc
0.9071 0.051 Td
()Tj
-0.004 Tc
0.4138 -0.051 Td
(nto)Tj
0 Tc
0.9128 0.051 Td
()Tj
-0.004 Tc
0.4422 -0.051 Td
(,)Tj
0.4422 0 Td
(Rena)Tj
0 Tc
1.6157 0.051 Td
()Tj
-0.004 Tc
0.4139 -0.051 Td
(ta)Tj
0.9524 0 Td
(Bor,)Tj
1.9049 0 Td
(A)Tj
0 Tc
0.1474 0.2608 Td
()Tj
-0.004 Tc
0.5329 -0.2608 Td
(gnes)Tj
2.0182 0 Td
(Milassin,)Tj
3.8268 0 Td
(Mariann)Tj
3.7133 0 Td
(Rutka,)Tj
2.8233 0 Td
(Anna)Tj
-31.9065 -1.2982 Td
(Fa)Tj
0 Tc
0.5499 0.051 Td
()Tj
-0.004 Tc
0.4138 -0.051 Td
(bia)Tj
0 Tc
0.7937 0.051 Td
()Tj
-0.004 Tc
0.4139 -0.051 Td
(n.)Tj
/F10 1 Tf
-3.3675 -1.8029 Td
(Supervision:)Tj
/F5 1 Tf
5.3971 0 Td
(Zolta)Tj
0 Tc
1.6724 0.0511 Td
()Tj
-0.004 Tc
0.4139 -0.0511 Td
(n)Tj
0.7653 0 Td
(Szepes,)Tj
3.0614 0 Td
(Ferenc)Tj
2.9367 0 Td
(Nagy,)Tj
2.5341 0 Td
(Tama)Tj
0 Tc
1.8879 0.0511 Td
()Tj
-0.004 Tc
0.4139 -0.0511 Td
(s)Tj
0.5782 0 Td
(Molna)Tj
0 Tc
2.2167 0.0511 Td
()Tj
-0.004 Tc
0.4139 -0.0511 Td
(r,)Tj
0.8163 0 Td
(Klaudia)Tj
3.3279 0 Td
(Farkas.)Tj
/F10 1 Tf
-26.4357 -1.7971 Td
(Validation:)Tj
/F5 1 Tf
4.9209 0 Td
(Tama)Tj
0 Tc
1.8822 0.051 Td
()Tj
-0.004 Tc
0.4138 -0.051 Td
(s)Tj
0.5839 0 Td
(Molna)Tj
0 Tc
2.2111 0.051 Td
()Tj
-0.004 Tc
0.4138 -0.051 Td
(r.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 247.011 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(References)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 204.8881 233.5181 cm
BT
/F2 1 Tf
1 TL
-0.005 Tc
0 0 Td
(1.)Tj
/F0 1 Tf
2.0763 0 Td
(Ananthak)Tj
4.1528 0 Td
(rishnan)Tj
3.4371 0 Td
(AN,)Tj
1.8638 0 Td
(Weber)Tj
3.1252 0 Td
(LR,)Tj
1.7504 0 Td
(Knox)Tj
2.4662 0 Td
(JF,)Tj
1.5945 0 Td
(Skaros)Tj
3.2882 0 Td
(S,)Tj
1.1551 0 Td
(Emmons)Tj
4.1103 0 Td
(J,)Tj
0.9921 0 Td
(Lundeen)Tj
4.0394 0 Td
(S)Tj
0.8787 0 Td
(et)Tj
1.0418 0 Td
(al.)Tj
1.2543 0 Td
(Perman)Tj
3.4441 0 Td
(ent)Tj
1.5875 0 Td
(work)Tj
2.296 0 Td
(dis-)Tj
-42.4775 -1.1905 Td
(ability)Tj
2.7213 0 Td
(in)Tj
0.978 0 Td
(Crohn's)Tj
3.6 0 Td
(disease.)Tj
3.8764 0 Td
(Am)Tj
1.7079 0 Td
(J)Tj
0.7087 0 Td
(Gastroenter)Tj
5.2016 0 Td
(ol)Tj
0.978 0 Td
(2008;)Tj
2.8984 0 Td
(103:)Tj
2.126 0 Td
(154161)Tj
0.83 0.64 0.02 0 k
4.0394 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.111)Tj
3.8197 0 Td
(1/j.1572-)Tj
-38.0696 -1.1835 Td
(0241.2007.)Tj
4.9111 0 Td
(01561.x)Tj
0 g
3.7205 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
2.9622 0 Td
(18076736)Tj
0 g
/F2 1 Tf
-13.6701 -1.6299 Td
(2.)Tj
/F0 1 Tf
2.0763 0 Td
(Burisch)Tj
3.5009 0 Td
(J,)Tj
0.985 0 Td
(Munkholm)Tj
4.7622 0 Td
(P.)Tj
1.1552 0 Td
(Inflamm)Tj
3.5008 0 Td
(atory)Tj
2.4095 0 Td
(bowel)Tj
2.7779 0 Td
(disease)Tj
3.6071 0 Td
(epidemi)Tj
3.43 0 Td
(ology.)Tj
2.8347 0 Td
(Curr)Tj
2.1331 0 Td
(Opin)Tj
2.296 0 Td
(Gastroenter)Tj
5.2016 0 Td
(ol,)Tj
1.2544 0 Td
(2013;)Tj
2.8984 0 Td
(29:)Tj
-42.7468 -1.1835 Td
(357362)Tj
0.83 0.64 0.02 0 k
4.0394 0 Td
(https://do)Tj
4.0465 0 Td
(i.org/10.1097)Tj
5.7332 0 Td
(/MOG.0)Tj
3.4653 0 Td
(b013e328362)Tj
6.0024 0 Td
(29fb)Tj
0 g
2.1331 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
2.9623 0 Td
(23695429)Tj
0 g
/F2 1 Tf
-30.4585 -1.6299 Td
(3.)Tj
/F0 1 Tf
2.0763 0 Td
(Burisch)Tj
3.5009 0 Td
(J,)Tj
0.985 0 Td
(Jess)Tj
2.2465 0 Td
(T,)Tj
1.1055 0 Td
(Martinato)Tj
4.3158 0 Td
(M,)Tj
1.3181 0 Td
(Lakatos)Tj
3.6638 0 Td
(PL;)Tj
1.7008 0 Td
(ECCO-EpiC)Tj
5.315 0 Td
(om.)Tj
1.8638 0 Td
(The)Tj
1.9205 0 Td
(burden)Tj
3.274 0 Td
(of)Tj
1.0418 0 Td
(inflammator)Tj
5.1378 0 Td
(y)Tj
0.7087 0 Td
(bowel)Tj
2.785 0 Td
(disease)Tj
-40.883 -1.1835 Td
(in)Tj
0.978 0 Td
(Europe.)Tj
3.6638 0 Td
(J)Tj
0.7158 0 Td
(Crohns)Tj
3.3874 0 Td
(Colitis,)Tj
3.1606 0 Td
(2013;)Tj
2.8985 0 Td
(7:)Tj
1.0347 0 Td
(322337)Tj
0.83 0.64 0.02 0 k
4.0394 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.101)Tj
3.8197 0 Td
(6/j.crohns.2)Tj
5.0811 0 Td
(013.01.010)Tj
0 g
5.1379 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
-39.3311 -1.1906 Td
(23395397)Tj
0 g
/F2 1 Tf
-2.0763 -1.6228 Td
(4.)Tj
/F0 1 Tf
2.0763 0 Td
(Lennard-Jon)Tj
5.5135 0 Td
(es)Tj
1.2543 0 Td
(J.)Tj
0.9921 0 Td
(Classifi)Tj
3.1536 0 Td
(cation)Tj
2.8418 0 Td
(of)Tj
1.0417 0 Td
(inflammato)Tj
4.8048 0 Td
(ry)Tj
1.0417 0 Td
(bowel)Tj
2.7851 0 Td
(disease.)Tj
3.8764 0 Td
(Scand)Tj
3.0047 0 Td
(J)Tj
0.7158 0 Td
(Gastroente)Tj
4.8685 0 Td
(rol)Tj
1.3111 0 Td
(Suppl.,)Tj
3.274 0 Td
(1989;)Tj
-40.4791 -1.1906 Td
(170:)Tj
2.1331 0 Td
(26.)Tj
2.1331 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
2.9622 0 Td
(2617184)Tj
0 g
/F2 1 Tf
-9.3047 -1.6228 Td
(5.)Tj
/F0 1 Tf
2.0763 0 Td
(Satsangi)Tj
4.0394 0 Td
(J,)Tj
0.9922 0 Td
(Silverberg)Tj
4.6347 0 Td
(MS,)Tj
1.9842 0 Td
(Vermei)Tj
3.1111 0 Td
(re)Tj
1.0913 0 Td
(S,)Tj
1.1552 0 Td
(Colombel)Tj
4.3653 0 Td
(JFThe)Tj
3.019 0 Td
(Montreal)Tj
4.0465 0 Td
(classific)Tj
3.4299 0 Td
(ation)Tj
2.3457 0 Td
(of)Tj
1.0417 0 Td
(inflammator)Tj
5.1379 0 Td
(y)Tj
0.7157 0 Td
(bowel)Tj
-41.1098 -1.1906 Td
(disease:)Tj
3.8765 0 Td
(controver)Tj
4.096 0 Td
(sies,)Tj
2.2465 0 Td
(consens)Tj
3.6567 0 Td
(us,)Tj
1.5379 0 Td
(and)Tj
1.8567 0 Td
(implication)Tj
4.6276 0 Td
(s.)Tj
0.985 0 Td
(Gut,)Tj
2.0906 0 Td
(2006;)Tj
2.8984 0 Td
(55:)Tj
1.5874 0 Td
(74975)Tj
3.267 0 Td
(3)Tj
0.83 0.64 0.02 0 k
0.7653 0 Td
(https://doi.or)Tj
5.4143 0 Td
(g/10.1136/)Tj
-38.9059 -1.1835 Td
(gut.2005)Tj
3.8198 0 Td
(.082909)Tj
0 g
3.7701 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
2.9693 0 Td
(1669874)Tj
3.8126 0 Td
(6)Tj
0 g
/F2 1 Tf
-16.4481 -1.6228 Td
(6.)Tj
/F0 1 Tf
2.0763 0 Td
(Best)Tj
2.1969 0 Td
(WR,)Tj
2.1402 0 Td
(Becktel)Tj
3.4512 0 Td
(JM,)Tj
1.8142 0 Td
(Singleton)Tj
4.3087 0 Td
(JW,)Tj
1.9276 0 Td
(Kern)Tj
2.296 0 Td
(F)Tj
0.8292 0 Td
(Jr.)Tj
1.311 0 Td
(Development)Tj
6.0166 0 Td
(of)Tj
1.0417 0 Td
(a)Tj
0.7654 0 Td
(Crohn's)Tj
3.6 0 Td
(disease)Tj
3.6 0 Td
(activity)Tj
3.2245 0 Td
(index.)Tj
-38.5232 -1.1906 Td
(National)Tj
3.8127 0 Td
(Cooperat)Tj
4.0394 0 Td
(ive)Tj
1.474 0 Td
(Crohn's)Tj
3.6 0 Td
(Disease)Tj
3.7701 0 Td
(Study.)Tj
3.0119 0 Td
(Gastroenter)Tj
5.2016 0 Td
(ology)Tj
2.5654 0 Td
(1976;)Tj
2.8913 0 Td
(70:)Tj
1.5874 0 Td
(439444)Tj
4.0394 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
2.9694 0 Td
(124870)Tj
3.2669 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 417.3165 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Disease)Tj
3.7701 0 Td
(outcome)Tj
3.9968 0 Td
(in)Tj
0.978 0 Td
(IBD)Tj
1.8638 0 Td
(in)Tj
0.978 0 Td
(a)Tj
0.7653 0 Td
(Hungarian)Tj
4.7481 0 Td
(center)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.02008)Tj
4.089 0 Td
(24)Tj
0 g
2.0906 0 Td
(July)Tj
1.9701 0 Td
(30,)Tj
1.5874 0 Td
(2018)Tj
35.894 0 Td
(7)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
155 0 obj
<>stream
endstream
endobj
156 0 obj
<>stream
endstream
endobj
157 0 obj
<>stream
endstream
endobj
158 0 obj
<>stream
endstream
endobj
159 0 obj
<>stream
endstream
endobj
160 0 obj
<>stream
endstream
endobj
161 0 obj
<>stream
endstream
endobj
162 0 obj
<>stream
BT
66.9477 0 Td
(8)Tj
ET
Q
endstream
endobj
163 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 165 0 R/Contents 166 0 R/TrimBox[0 0 612 792]>>
endobj
165 0 obj
[167 0 R 168 0 R 169 0 R 170 0 R 171 0 R 172 0 R 173 0 R 174 0 R 175 0 R 176 0 R 177 0 R 178 0 R 179 0 R 180 0 R 181 0 R 182 0 R 183 0 R 184 0 R 185 0 R 186 0 R 187 0 R 188 0 R 189 0 R 190 0 R 191 0 R 192 0 R 193 0 R 194 0 R 195 0 R 196 0 R 197 0 R 198 0 R 199 0 R 200 0 R 201 0 R 202 0 R 203 0 R 204 0 R 205 0 R 206 0 R 207 0 R 208 0 R 209 0 R 210 0 R 211 0 R 212 0 R 213 0 R 214 0 R 215 0 R 216 0 R 217 0 R]
endobj
167 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref007)>>
endobj
168 0 obj
<>/Border[0 0 0]/A 218 0 R>>
endobj
218 0 obj
<>
endobj
169 0 obj
<>/Border[0 0 0]/A 219 0 R>>
endobj
219 0 obj
<>
endobj
170 0 obj
<>/Border[0 0 0]/A 220 0 R>>
endobj
220 0 obj
<>
endobj
171 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref008)>>
endobj
172 0 obj
<>/Border[0 0 0]/A 221 0 R>>
endobj
221 0 obj
<>
endobj
173 0 obj
<>/Border[0 0 0]/A 222 0 R>>
endobj
222 0 obj
<>
endobj
174 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref009)>>
endobj
175 0 obj
<>/Border[0 0 0]/A 223 0 R>>
endobj
223 0 obj
<>
endobj
176 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref010)>>
endobj
177 0 obj
<>/Border[0 0 0]/A 224 0 R>>
endobj
224 0 obj
<>
endobj
178 0 obj
<>/Border[0 0 0]/A 225 0 R>>
endobj
225 0 obj
<>
endobj
179 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref011)>>
endobj
180 0 obj
<>/Border[0 0 0]/A 226 0 R>>
endobj
226 0 obj
<>
endobj
181 0 obj
<>/Border[0 0 0]/A 227 0 R>>
endobj
227 0 obj
<>
endobj
182 0 obj
<>/Border[0 0 0]/A 228 0 R>>
endobj
228 0 obj
<>
endobj
183 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref012)>>
endobj
184 0 obj
<>/Border[0 0 0]/A 229 0 R>>
endobj
229 0 obj
<>
endobj
185 0 obj
<>/Border[0 0 0]/A 230 0 R>>
endobj
230 0 obj
<>
endobj
186 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref013)>>
endobj
187 0 obj
<>/Border[0 0 0]/A 231 0 R>>
endobj
231 0 obj
<>
endobj
188 0 obj
<>/Border[0 0 0]/A 232 0 R>>
endobj
232 0 obj
<>
endobj
189 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref014)>>
endobj
190 0 obj
<>/Border[0 0 0]/A 233 0 R>>
endobj
233 0 obj
<>
endobj
191 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref015)>>
endobj
192 0 obj
<>/Border[0 0 0]/A 234 0 R>>
endobj
234 0 obj
<>
endobj
193 0 obj
<>/Border[0 0 0]/A 235 0 R>>
endobj
235 0 obj
<>
endobj
194 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref016)>>
endobj
195 0 obj
<>/Border[0 0 0]/A 236 0 R>>
endobj
236 0 obj
<>
endobj
196 0 obj
<>/Border[0 0 0]/A 237 0 R>>
endobj
237 0 obj
<>
endobj
197 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref017)>>
endobj
198 0 obj
<>/Border[0 0 0]/A 238 0 R>>
endobj
238 0 obj
<>
endobj
199 0 obj
<>/Border[0 0 0]/A 239 0 R>>
endobj
239 0 obj
<>
endobj
200 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref018)>>
endobj
201 0 obj
<>/Border[0 0 0]/A 240 0 R>>
endobj
240 0 obj
<>
endobj
202 0 obj
<>/Border[0 0 0]/A 241 0 R>>
endobj
241 0 obj
<>
endobj
203 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref019)>>
endobj
204 0 obj
<>/Border[0 0 0]/A 242 0 R>>
endobj
242 0 obj
<>
endobj
205 0 obj
<>/Border[0 0 0]/A 243 0 R>>
endobj
243 0 obj
<>
endobj
206 0 obj
<>/Border[0 0 0]/A 244 0 R>>
endobj
244 0 obj
<>
endobj
207 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref020)>>
endobj
208 0 obj
<>/Border[0 0 0]/A 245 0 R>>
endobj
245 0 obj
<>
endobj
209 0 obj
<>/Border[0 0 0]/A 246 0 R>>
endobj
246 0 obj
<>
endobj
210 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref021)>>
endobj
211 0 obj
<>/Border[0 0 0]/A 247 0 R>>
endobj
247 0 obj
<>
endobj
212 0 obj
<>/Border[0 0 0]/A 248 0 R>>
endobj
248 0 obj
<>
endobj
213 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200824.ref022)>>
endobj
214 0 obj
<>/Border[0 0 0]/A 249 0 R>>
endobj
249 0 obj
<>
endobj
215 0 obj
<>/Border[0 0 0]/A 250 0 R>>
endobj
250 0 obj
<>
endobj
216 0 obj
<>/Border[0 0 0]/A 251 0 R>>
endobj
251 0 obj
<>
endobj
217 0 obj
<>/Border[0 0 0]/A 252 0 R>>
endobj
252 0 obj
<>
endobj
166 0 obj
[253 0 R 254 0 R 255 0 R 256 0 R 257 0 R 258 0 R 259 0 R 260 0 R 261 0 R 262 0 R 263 0 R 264 0 R 265 0 R 266 0 R 267 0 R 268 0 R 269 0 R]
endobj
253 0 obj
<>stream
q
0.83 0.64 0.02 0 k
522.5953 698.1165 m
572.485 698.1165 l
h
f*
221.4992 688.6488 m
339.0803 688.6488 l
h
f*
364.5354 688.6488 m
395.1496 688.6488 l
h
f*
270.822 666.1417 m
395.4331 666.1417 l
h
f*
420.8882 666.1417 m
455.811 666.1417 l
h
f*
264.4724 634.1669 m
299.3953 634.1669 l
h
f*
357.9024 611.6598 m
497.3102 611.6598 l
h
f*
522.7654 611.6598 m
557.7449 611.6598 l
h
f*
435.0047 589.1528 m
565.2283 589.1528 l
h
f*
221.4992 579.6283 m
234.652 579.6283 l
h
f*
260.1071 579.6283 m
295.0299 579.6283 l
h
f*
380.6362 557.1213 m
519.6472 557.1213 l
h
f*
221.4992 547.6535 m
256.422 547.6535 l
h
f*
236.3528 515.622 m
408.0756 515.622 l
h
f*
433.5307 515.622 m
468.5102 515.622 l
h
f*
260.1071 483.6472 m
295.0299 483.6472 l
h
f*
308.863 451.6157 m
463.5213 451.6157 l
h
f*
488.9764 451.6157 m
523.9559 451.6157 l
h
f*
289.6441 419.6409 m
473.3858 419.6409 l
h
f*
498.8409 419.6409 m
533.7638 419.6409 l
h
f*
415.5591 387.6661 m
530.5323 387.6661 l
h
f*
221.4992 378.1417 m
256.422 378.1417 l
h
f*
341.2913 346.1669 m
495.9496 346.1669 l
h
f*
521.4047 346.1669 m
556.3276 346.1669 l
h
f*
546.8598 323.6598 m
570.5575 323.6598 l
h
f*
221.4992 314.1354 m
337.2094 314.1354 l
h
f*
362.6646 314.1354 m
397.6441 314.1354 l
h
f*
352.1764 282.1606 m
478.0346 282.1606 l
h
f*
503.4898 282.1606 m
538.4126 282.1606 l
h
f*
262.5449 250.1291 m
388.4031 250.1291 l
h
f*
413.8583 250.1291 m
448.7811 250.1291 l
h
f*
525.1465 227.622 m
575.0362 227.622 l
h
f*
221.4992 218.1543 m
325.5307 218.1543 l
h
f*
350.9858 218.1543 m
385.852 218.1543 l
h
f*
0 g
1 j
1 J
0 w
7.9999 0 0 7.9999 204.8881 708.7181 cm
BT
/F2 1 Tf
1 TL
-0.005 Tc
0 0 Td
(7.)Tj
/F0 1 Tf
2.0763 0 Td
(Schroeder)Tj
4.7552 0 Td
(KW,)Tj
2.0906 0 Td
(Tremaine)Tj
4.3795 0 Td
(WJ,)Tj
1.9276 0 Td
(Ilstrup)Tj
2.8985 0 Td
(DM.)Tj
2.0267 0 Td
(Coated)Tj
3.3875 0 Td
(oral)Tj
1.8567 0 Td
(5-amino)Tj
3.5433 0 Td
(salicylic)Tj
3.593 0 Td
(acid)Tj
2.0197 0 Td
(therapy)Tj
3.4937 0 Td
(for)Tj
1.3677 0 Td
(mildly)Tj
2.7284 0 Td
(to)Tj
1.0346 0 Td
(moder-)Tj
-41.1027 -1.1905 Td
(ately)Tj
2.2961 0 Td
(active)Tj
2.7851 0 Td
(ulcerati)Tj
3.1536 0 Td
(ve)Tj
1.2614 0 Td
(colitis.)Tj
2.941 0 Td
(A)Tj
0.8787 0 Td
(randomiz)Tj
4.0394 0 Td
(ed)Tj
1.311 0 Td
(study.)Tj
2.8489 0 Td
(N)Tj
0.9354 0 Td
(Engl)Tj
2.1827 0 Td
(J)Tj
0.7087 0 Td
(Med)Tj
2.1402 0 Td
(1987;)Tj
2.8984 0 Td
(317:)Tj
2.126 0 Td
(16251629)Tj
0.83 0.64 0.02 0 k
5.1307 0 Td
(https://doi.or)Tj
5.4143 0 Td
(g/)Tj
-43.0516 -1.1835 Td
(10.1056/)Tj
3.8198 0 Td
(NEJM198712)Tj
5.9669 0 Td
(2431726)Tj
3.8127 0 Td
(03)Tj
0 g
1.311 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
2.9693 0 Td
(3317057)Tj
0 g
/F2 1 Tf
-19.956 -1.6228 Td
(8.)Tj
/F0 1 Tf
2.0763 0 Td
(Khor)Tj
2.2961 0 Td
(B,)Tj
1.1552 0 Td
(Gardet)Tj
3.2315 0 Td
(A,)Tj
1.1551 0 Td
(Xavier)Tj
3.0047 0 Td
(RJ.)Tj
1.7009 0 Td
(Genetics)Tj
4.1031 0 Td
(and)Tj
1.8567 0 Td
(pathogenes)Tj
5.1308 0 Td
(is)Tj
0.9283 0 Td
(of)Tj
1.0418 0 Td
(inflammator)Tj
5.1378 0 Td
(y)Tj
0.7158 0 Td
(bowel)Tj
2.7779 0 Td
(disease.)Tj
3.8765 0 Td
(Nature,)Tj
3.4441 0 Td
(2011;)Tj
-41.5563 -1.1906 Td
(474:)Tj
2.1331 0 Td
(307317)Tj
0.83 0.64 0.02 0 k
4.0323 0 Td
(https://doi.or)Tj
5.4143 0 Td
(g/10.1038/n)Tj
5.1874 0 Td
(ature10209)Tj
0 g
5.1874 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
2.9694 0 Td
(21677747)Tj
0 g
/F2 1 Tf
-27.0002 -1.6228 Td
(9.)Tj
/F0 1 Tf
2.0763 0 Td
(Cosnes)Tj
3.5576 0 Td
(J,)Tj
0.985 0 Td
(Carbonn)Tj
3.763 0 Td
(el)Tj
0.9851 0 Td
(F,)Tj
1.0984 0 Td
(Carrat)Tj
2.9551 0 Td
(F,)Tj
1.0985 0 Td
(Beaugerie)Tj
4.6914 0 Td
(L,)Tj
1.0417 0 Td
(Cattan)Tj
3.1181 0 Td
(S,)Tj
1.1552 0 Td
(Gendre)Tj
3.5079 0 Td
(J.)Tj
0.985 0 Td
(Effects)Tj
3.2386 0 Td
(of)Tj
1.0418 0 Td
(current)Tj
3.2811 0 Td
(and)Tj
1.8496 0 Td
(former)Tj
3.0685 0 Td
(ciga-)Tj
-41.4216 -1.1906 Td
(rette)Tj
2.1898 0 Td
(smoking)Tj
3.8835 0 Td
(on)Tj
1.3111 0 Td
(the)Tj
1.5803 0 Td
(clinical)Tj
3.1535 0 Td
(course)Tj
3.1678 0 Td
(of)Tj
1.0417 0 Td
(Crohn's)Tj
3.6001 0 Td
(disease.)Tj
3.8764 0 Td
(Aliment.)Tj
3.7772 0 Td
(Pharma)Tj
3.4441 0 Td
(col.)Tj
1.7504 0 Td
(Ther.,)Tj
2.7921 0 Td
(1999;)Tj
2.8985 0 Td
(13,)Tj
1.5874 0 Td
(1403)Tj
-40.0539 -1.1835 Td
(1411)Tj
2.4024 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
2.9693 0 Td
(105715)Tj
3.267 0 Td
(95)Tj
0 g
/F2 1 Tf
-11.2606 -1.6299 Td
(10.)Tj
/F0 1 Tf
2.6219 0 Td
(Lakatos)Tj
3.6639 0 Td
(PL,)Tj
1.7008 0 Td
(Szamosi)Tj
3.9968 0 Td
(T,Lakatos)Tj
4.5426 0 Td
(L.)Tj
1.0417 0 Td
(Smoking)Tj
4.0465 0 Td
(in)Tj
0.978 0 Td
(inflammator)Tj
5.1378 0 Td
(y)Tj
0.7158 0 Td
(bowel)Tj
2.7779 0 Td
(diseases:)Tj
4.3725 0 Td
(good,)Tj
2.6788 0 Td
(bad)Tj
1.8567 0 Td
(or)Tj
1.0913 0 Td
(ugly?)Tj
2.5583 0 Td
(World)Tj
-41.1594 -1.1835 Td
(J.)Tj
0.9922 0 Td
(Gastro)Tj
2.9551 0 Td
(enterol.,)Tj
3.7701 0 Td
(2007)Tj
2.6221 0 Td
(13,)Tj
1.5874 0 Td
(61346)Tj
3.267 0 Td
(139)Tj
0.83 0.64 0.02 0 k
1.8567 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.3748/)Tj
4.6418 0 Td
(wjg.v13.i46.6)Tj
5.7331 0 Td
(134)Tj
0 g
1.8567 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
2.9622 0 Td
(18069751)Tj
0 g
/F2 1 Tf
-40.2805 -1.6299 Td
(11.)Tj
/F0 1 Tf
2.6219 0 Td
(Cosnes)Tj
3.5576 0 Td
(J.)Tj
0.985 0 Td
(Tobacco)Tj
3.9969 0 Td
(and)Tj
1.8567 0 Td
(IBD:)Tj
2.1402 0 Td
(relevance)Tj
4.4717 0 Td
(in)Tj
0.9779 0 Td
(the)Tj
1.5874 0 Td
(understanding)Tj
6.4418 0 Td
(of)Tj
1.0418 0 Td
(disease)Tj
3.6 0 Td
(mechanis)Tj
4.2024 0 Td
(ms)Tj
1.5449 0 Td
(and)Tj
1.8496 0 Td
(clinical)Tj
3.1536 0 Td
(prac-)Tj
-41.4075 -1.1835 Td
(tice.)Tj
2.0197 0 Td
(Best)Tj
2.1969 0 Td
(Pract.)Tj
2.7992 0 Td
(Res.)Tj
2.2394 0 Td
(Clin.)Tj
2.1827 0 Td
(Gastroen)Tj
4.0465 0 Td
(terol.,)Tj
2.6788 0 Td
(2004;)Tj
2.8984 0 Td
(18,)Tj
1.5874 0 Td
(481496)Tj
0.83 0.64 0.02 0 k
4.0394 0 Td
(https://)Tj
2.9552 0 Td
(doi.org/10.10)Tj
5.7331 0 Td
(16/j.bpg)Tj
3.4866 0 Td
(.2003.12.)Tj
-38.8633 -1.1906 Td
(003)Tj
0 g
1.8568 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
2.9693 0 Td
(151578)Tj
3.2669 0 Td
(22)Tj
0 g
/F2 1 Tf
-10.7149 -1.6228 Td
(12.)Tj
/F0 1 Tf
2.6219 0 Td
(Andersso)Tj
4.1528 0 Td
(n)Tj
0.7654 0 Td
(RE,)Tj
1.8709 0 Td
(Olaison)Tj
3.5504 0 Td
(G,)Tj
1.2685 0 Td
(Tysk)Tj
2.3032 0 Td
(C,)Tj
1.2118 0 Td
(Ekbom)Tj
3.2882 0 Td
(A.)Tj
1.1551 0 Td
(Appendec)Tj
4.4221 0 Td
(tomy)Tj
2.3599 0 Td
(is)Tj
0.9283 0 Td
(followed)Tj
3.8127 0 Td
(by)Tj
1.2614 0 Td
(increased)Tj
4.4717 0 Td
(risk)Tj
1.7504 0 Td
(of)Tj
1.0417 0 Td
(Crohn's)Tj
-39.6145 -1.1906 Td
(disease.)Tj
3.8765 0 Td
(Gastroenter)Tj
5.2016 0 Td
(ology,)Tj
2.8346 0 Td
(2003;)Tj
2.8985 0 Td
(124:)Tj
2.1331 0 Td
(4046)Tj
0.83 0.64 0.02 0 k
2.948 0 Td
(https:/)Tj
2.6788 0 Td
(/doi.org/10.10)Tj
6.0095 0 Td
(53/gast.200)Tj
5.1378 0 Td
(3.50021)Tj
0 g
3.763 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
-37.4814 -1.1834 Td
(12512028)Tj
0 g
/F2 1 Tf
-2.6219 -1.6229 Td
(13.)Tj
/F0 1 Tf
2.6219 0 Td
(Gardenbr)Tj
4.1528 0 Td
(oek)Tj
1.8071 0 Td
(TJ,Eshuis)Tj
4.5497 0 Td
(EJ,)Tj
1.6441 0 Td
(Ponsioen)Tj
4.3158 0 Td
(CI,)Tj
1.4811 0 Td
(Ubbink)Tj
3.274 0 Td
(DT,)Tj
1.8142 0 Td
(D'Haens)Tj
3.9827 0 Td
(GR,)Tj
1.9843 0 Td
(Bemelman)Tj
4.9252 0 Td
(WA.)Tj
2.0906 0 Td
(The)Tj
1.9205 0 Td
(effect)Tj
2.6291 0 Td
(of)Tj
-40.5712 -1.1905 Td
(appendec)Tj
4.3087 0 Td
(tomy)Tj
2.3599 0 Td
(on)Tj
1.311 0 Td
(the)Tj
1.5874 0 Td
(course)Tj
3.1678 0 Td
(of)Tj
1.0417 0 Td
(ulcerative)Tj
4.4221 0 Td
(colitis:)Tj
2.941 0 Td
(a)Tj
0.7653 0 Td
(systematic)Tj
4.8686 0 Td
(review.)Tj
3.3378 0 Td
(Colorectal)Tj
4.6347 0 Td
(Dis.,)Tj
2.1827 0 Td
(2012)Tj
2.622 0 Td
(14:)Tj
1.5875 0 Td
(545)Tj
-41.1382 -1.1906 Td
(553)Tj
0.83 0.64 0.02 0 k
1.8568 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.111)Tj
3.8197 0 Td
(1/j.1463-131)Tj
5.4567 0 Td
(8.2011.0)Tj
3.8197 0 Td
(2600.x)Tj
0 g
3.1749 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
2.9622 0 Td
(21689293)Tj
0 g
/F2 1 Tf
-29.1261 -1.6228 Td
(14.)Tj
/F0 1 Tf
2.6219 0 Td
(Radford-)Tj
3.8198 0 Td
(Smith)Tj
2.7425 0 Td
(G.L,Edwa)Tj
4.33 0 Td
(rds)Tj
1.5874 0 Td
(JE,)Tj
1.6512 0 Td
(Purdie)Tj
3.0543 0 Td
(DM,)Tj
2.0339 0 Td
(Pandey)Tj
3.3307 0 Td
(a)Tj
0.7654 0 Td
(N,)Tj
1.2047 0 Td
(Watson)Tj
3.5646 0 Td
(M,)Tj
1.3252 0 Td
(Martzin)Tj
3.4441 0 Td
(NG)Tj
1.7079 0 Td
(et)Tj
1.0418 0 Td
(al.)Tj
1.2472 0 Td
(Protective)Tj
4.5993 0 Td
(role)Tj
1.8496 0 Td
(of)Tj
-43.2996 -1.1906 Td
(appendic)Tj
3.9757 0 Td
(ectomy)Tj
3.4016 0 Td
(on)Tj
1.311 0 Td
(onset)Tj
2.6221 0 Td
(and)Tj
1.8567 0 Td
(severity)Tj
3.6071 0 Td
(of)Tj
1.0417 0 Td
(ulcerative)Tj
4.415 0 Td
(colitis)Tj
2.6717 0 Td
(and)Tj
1.8567 0 Td
(Crohn's)Tj
3.6 0 Td
(disease,)Tj
3.8764 0 Td
(Gut,)Tj
2.0906 0 Td
(2002;)Tj
2.8914 0 Td
(51:)Tj
1.5874 0 Td
(808)Tj
-40.8051 -1.1835 Td
(813)Tj
1.8568 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
2.9693 0 Td
(124277)Tj
3.2669 0 Td
(81)Tj
0 g
/F2 1 Tf
-10.7149 -1.6228 Td
(15.)Tj
/F0 1 Tf
2.6219 0 Td
(Henriksen)Tj
4.6418 0 Td
(M,)Tj
1.3181 0 Td
(Jahnsen)Tj
3.9331 0 Td
(J,)Tj
0.9922 0 Td
(Lyrgen)Tj
3.2173 0 Td
(I,)Tj
0.7725 0 Td
(Aadland)Tj
3.8197 0 Td
(E,)Tj
1.1551 0 Td
(Schulz)Tj
3.1677 0 Td
(T,)Tj
1.1056 0 Td
(Vatn)Tj
2.2464 0 Td
(MH)Tj
1.7575 0 Td
(et)Tj
1.0418 0 Td
(al.)Tj
1.2543 0 Td
(Clinical)Tj
3.3662 0 Td
(course)Tj
3.1677 0 Td
(in)Tj
0.978 0 Td
(Crohn's)Tj
3.6071 0 Td
(dis-)Tj
-41.5421 -1.1906 Td
(ease:)Tj
2.6221 0 Td
(Results)Tj
3.5008 0 Td
(of)Tj
1.0418 0 Td
(a)Tj
0.7653 0 Td
(five-year)Tj
3.9827 0 Td
(population-)Tj
4.8473 0 Td
(based)Tj
2.8985 0 Td
(follow-up)Tj
4.1386 0 Td
(study)Tj
2.5724 0 Td
(\(the)Tj
1.9134 0 Td
(IBSEN)Tj
3.189 0 Td
(study\),)Tj
3.1749 0 Td
(Scand)Tj
3.0047 0 Td
(J)Tj
0.7158 0 Td
(Gastroen-)Tj
-38.3673 -1.1906 Td
(terol,)Tj
2.4024 0 Td
(2007;)Tj
2.8985 0 Td
(42:)Tj
1.5803 0 Td
(602610)Tj
0.83 0.64 0.02 0 k
4.0394 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.108)Tj
3.8197 0 Td
(0/0036552060)Tj
6.2788 0 Td
(1076124)Tj
0 g
4.0394 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
2.9623 0 Td
(17454881)Tj
0 g
/F2 1 Tf
-36.0569 -1.6228 Td
(16.)Tj
/F0 1 Tf
2.6219 0 Td
(Henriksen)Tj
4.6418 0 Td
(M,)Tj
1.3181 0 Td
(Jahnsen)Tj
3.9331 0 Td
(J,)Tj
0.9922 0 Td
(Lygren)Tj
3.2173 0 Td
(I,)Tj
0.7725 0 Td
(Sauar)Tj
2.8417 0 Td
(J,)Tj
0.9922 0 Td
(Kjellevold)Tj
/F6 1 Tf
4.4079 0 Td
[( )]TJ
/F0 1 Tf
(,)Tj
1.2543 0 Td
(Schulz)Tj
3.1748 0 Td
(T)Tj
0.8221 0 Td
(et)Tj
1.0417 0 Td
(al.)Tj
1.2544 0 Td
(Ulcerative)Tj
4.585 0 Td
(colitis)Tj
2.6646 0 Td
(and)Tj
1.8567 0 Td
(clinical)Tj
-39.7704 -1.1835 Td
(course:)Tj
3.4442 0 Td
(Results)Tj
3.5008 0 Td
(of)Tj
1.0417 0 Td
(a)Tj
0.7654 0 Td
(5)Tj
0.7653 0 Td
(year)Tj
2.126 0 Td
(population-)Tj
4.8473 0 Td
(based)Tj
2.8985 0 Td
(follow-up)Tj
4.1386 0 Td
(study)Tj
2.5724 0 Td
(\(The)Tj
2.2465 0 Td
(IBSEN)Tj
3.189 0 Td
(study\),)Tj
3.1749 0 Td
(Inflamm)Tj
3.7205 0 Td
(Bowel)Tj
2.8984 0 Td
(Dis,)Tj
-41.3295 -1.1905 Td
(2006;)Tj
2.8985 0 Td
(12:)Tj
1.5874 0 Td
(54355)Tj
3.267 0 Td
(0)Tj
0.83 0.64 0.02 0 k
0.7653 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.1097)Tj
4.3654 0 Td
(/01.MIB.000)Tj
5.315 0 Td
(0225339.9148)Tj
6.2788 0 Td
(4.fc)Tj
0 g
1.8071 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
2.9693 0 Td
(168043)Tj
3.267 0 Td
(90)Tj
0 g
/F2 1 Tf
-40.5569 -1.6229 Td
(17.)Tj
/F0 1 Tf
2.6219 0 Td
(Niewiadom)Tj
4.8544 0 Td
(ski)Tj
1.4244 0 Td
(O,)Tj
1.2685 0 Td
(Studd)Tj
2.7922 0 Td
(C,)Tj
1.2047 0 Td
(Hair)Tj
2.0126 0 Td
(C,)Tj
1.2119 0 Td
(Wilson)Tj
3.1677 0 Td
(J,)Tj
0.9921 0 Td
(Ding)Tj
2.2323 0 Td
(NS,)Tj
1.8638 0 Td
(Heerasing)Tj
4.6985 0 Td
(N)Tj
0.9284 0 Td
(et)Tj
1.0417 0 Td
(al.)Tj
1.2543 0 Td
(A)Tj
0.8788 0 Td
(prospective)Tj
5.2441 0 Td
(populat)Tj
3.2103 0 Td
(ion-)Tj
-40.2807 -1.1905 Td
(based)Tj
2.8985 0 Td
(cohort)Tj
2.948 0 Td
(of)Tj
1.0418 0 Td
(inflammator)Tj
5.1378 0 Td
(y)Tj
0.7087 0 Td
(bowel)Tj
2.7851 0 Td
(disease)Tj
3.6 0 Td
(in)Tj
0.9779 0 Td
(the)Tj
1.5875 0 Td
(biologics)Tj
4.0252 0 Td
(era-Disea)Tj
4.252 0 Td
(se)Tj
1.2614 0 Td
(course)Tj
3.1678 0 Td
(and)Tj
1.8567 0 Td
(predictors)Tj
4.5354 0 Td
(of)Tj
-40.7838 -1.1835 Td
(severity.)Tj
3.8835 0 Td
(J)Tj
0.7087 0 Td
(Gastroenter)Tj
5.2016 0 Td
(ol)Tj
0.978 0 Td
(Hepatol,)Tj
3.8764 0 Td
(2015;)Tj
2.8984 0 Td
(30:)Tj
1.5875 0 Td
(134613)Tj
3.8126 0 Td
(53)Tj
0.83 0.64 0.02 0 k
1.311 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.1111/)Tj
4.6418 0 Td
(jgh.12967)Tj
0 g
4.5284 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
-38.8421 -1.1906 Td
(25867770)Tj
0 g
/F2 1 Tf
-2.6219 -1.6228 Td
(18.)Tj
/F0 1 Tf
2.6219 0 Td
(Solberg)Tj
3.6001 0 Td
(IC,)Tj
1.4811 0 Td
(Lygren)Tj
3.2244 0 Td
(I,)Tj
0.7725 0 Td
(Jahnsen)Tj
3.9331 0 Td
(J,)Tj
0.985 0 Td
(Aadland)Tj
3.8197 0 Td
(E,)Tj
1.1552 0 Td
(H)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(ie)Tj
2.289 0 Td
(O,)Tj
1.2685 0 Td
(Cvancarov)Tj
4.6984 0 Td
(a)Tj
0.7654 0 Td
(M)Tj
1.0488 0 Td
(et)Tj
1.0418 0 Td
(al.)Tj
1.2543 0 Td
(Clinical)Tj
3.3662 0 Td
(course)Tj
3.1677 0 Td
(during)Tj
2.941 0 Td
(the)Tj
1.5874 0 Td
(first)Tj
-42.3996 -1.1906 Td
(10)Tj
1.3111 0 Td
(years)Tj
2.622 0 Td
(of)Tj
1.0418 0 Td
(ulcerative)Tj
4.415 0 Td
(colitis:)Tj
2.948 0 Td
(results)Tj
3.1111 0 Td
(from)Tj
2.1969 0 Td
(a)Tj
0.7653 0 Td
(popula)Tj
2.9339 0 Td
(tion-based)Tj
4.8048 0 Td
(inception)Tj
4.1386 0 Td
(cohort)Tj
2.9551 0 Td
(\(IBSEN)Tj
3.515 0 Td
(Study\),)Tj
3.3378 0 Td
(Scand)Tj
3.0119 0 Td
(J)Tj
-43.1083 -1.1835 Td
(Gastroenter)Tj
5.2017 0 Td
(ol,)Tj
1.2543 0 Td
(2009;)Tj
2.8914 0 Td
(44:)Tj
1.5874 0 Td
(431440)Tj
0.83 0.64 0.02 0 k
4.0394 0 Td
(https://doi.o)Tj
5.0811 0 Td
(rg/10.1080/00)Tj
6.0662 0 Td
(36552080)Tj
4.3583 0 Td
(2600961)Tj
0 g
4.0394 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
2.9693 0 Td
(19101844)Tj
0 g
/F2 1 Tf
-40.1104 -1.6299 Td
(19.)Tj
/F0 1 Tf
2.6219 0 Td
(Dias)Tj
2.1827 0 Td
(CC,)Tj
1.9205 0 Td
(Rodrigu)Tj
3.43 0 Td
(es)Tj
1.2614 0 Td
(PP,)Tj
1.8142 0 Td
(da)Tj
1.311 0 Td
(Costa-Per)Tj
4.4292 0 Td
(eira)Tj
1.8496 0 Td
(A,)Tj
1.1551 0 Td
(Magro)Tj
3.0119 0 Td
(F.)Tj
1.0984 0 Td
(Clinical)Tj
3.3733 0 Td
(prognos)Tj
3.5433 0 Td
(tic)Tj
1.2047 0 Td
(factors)Tj
3.1749 0 Td
(for)Tj
1.3677 0 Td
(disabling)Tj
4.0819 0 Td
(Crohn's)Tj
-40.2098 -1.1835 Td
(disease:)Tj
3.8765 0 Td
(A)Tj
0.8787 0 Td
(systematic)Tj
4.8756 0 Td
(review)Tj
3.0544 0 Td
(and)Tj
1.8567 0 Td
(meta-ana)Tj
4.1528 0 Td
(lysis,)Tj
2.4024 0 Td
(World)Tj
2.7921 0 Td
(J)Tj
0.7158 0 Td
(Gastroen)Tj
4.0465 0 Td
(terol,)Tj
2.4023 0 Td
(2013;)Tj
2.8985 0 Td
(19:)Tj
1.5874 0 Td
(38663871)Tj
0.83 0.64 0.02 0 k
5.1307 0 Td
(https://)Tj
-40.6704 -1.1905 Td
(doi.org/10.37)Tj
5.7261 0 Td
(48/wjg.v19.i2)Tj
5.7331 0 Td
(4.3866)Tj
0 g
3.2244 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
2.9623 0 Td
(23840127)Tj
0 g
/F2 1 Tf
-20.2678 -1.6229 Td
(20.)Tj
/F0 1 Tf
2.6219 0 Td
(Schoepfe)Tj
4.1528 0 Td
(r)Tj
0.5528 0 Td
(AM,)Tj
1.9772 0 Td
(Dehlavi)Tj
3.4866 0 Td
(MA,)Tj
1.9843 0 Td
(Fourni)Tj
2.778 0 Td
(er)Tj
1.0984 0 Td
(N,)Tj
1.2047 0 Td
(Safroneev)Tj
4.4788 0 Td
(a)Tj
0.7654 0 Td
(E,)Tj
1.1551 0 Td
(Straumann)Tj
5.0386 0 Td
(A,)Tj
1.1551 0 Td
(Pittet)Tj
2.4662 0 Td
(V)Tj
0.8787 0 Td
(et)Tj
1.0347 0 Td
(al.)Tj
1.2543 0 Td
(Diagnostic)Tj
4.8048 0 Td
(delay)Tj
2.5583 0 Td
(in)Tj
-42.8248 -1.1905 Td
(Crohn's)Tj
3.6001 0 Td
(disease)Tj
3.6 0 Td
(is)Tj
0.9284 0 Td
(associated)Tj
4.9181 0 Td
(with)Tj
1.963 0 Td
(a)Tj
0.7654 0 Td
(complicated)Tj
5.4638 0 Td
(disease)Tj
3.6 0 Td
(course)Tj
3.1678 0 Td
(and)Tj
1.8567 0 Td
(increased)Tj
4.4717 0 Td
(operation)Tj
4.3087 0 Td
(rate,)Tj
2.1897 0 Td
(Am)Tj
1.7079 0 Td
(J)Tj
-42.5413 -1.1835 Td
(Gastroenter)Tj
5.2017 0 Td
(ol)Tj
0.9779 0 Td
(2013;)Tj
2.8985 0 Td
(108:)Tj
2.126 0 Td
(17441753)Tj
0.83 0.64 0.02 0 k
5.1307 0 Td
(https://doi.o)Tj
5.0812 0 Td
(rg/10.1038/aj)Tj
5.7331 0 Td
(g.2013.2)Tj
3.8197 0 Td
(48)Tj
0 g
1.311 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
2.9693 0 Td
(23978953)Tj
0 g
/F2 1 Tf
-37.871 -1.6299 Td
(21.)Tj
/F0 1 Tf
2.6219 0 Td
(Gower-R)Tj
3.9402 0 Td
(ousseau)Tj
3.9331 0 Td
(C,)Tj
1.2119 0 Td
(Dauchet)Tj
3.8764 0 Td
(L,)Tj
1.0417 0 Td
(Vernier-M)Tj
4.3158 0 Td
(assouille)Tj
4.0323 0 Td
(G,)Tj
1.2685 0 Td
(Tilloy)Tj
2.5016 0 Td
(E,)Tj
1.1551 0 Td
(Brazier)Tj
3.3308 0 Td
(F,)Tj
1.1055 0 Td
(Merle)Tj
2.6788 0 Td
(V)Tj
0.8787 0 Td
(et)Tj
1.0417 0 Td
(al.)Tj
1.2544 0 Td
(The)Tj
1.9134 0 Td
(natural)Tj
3.2173 0 Td
(his-)Tj
-42.6972 -1.1835 Td
(tory)Tj
1.8638 0 Td
(of)Tj
1.0418 0 Td
(pediatr)Tj
2.9906 0 Td
(ic)Tj
0.9283 0 Td
(ulcerative)Tj
4.415 0 Td
(colitis:)Tj
2.9481 0 Td
(a)Tj
0.7653 0 Td
(popula)Tj
2.9339 0 Td
(tion-based)Tj
4.8048 0 Td
(cohort)Tj
2.9551 0 Td
(study,)Tj
2.8418 0 Td
(Am)Tj
1.7078 0 Td
(J)Tj
0.7158 0 Td
(Gastroe)Tj
3.5008 0 Td
(nterol)Tj
2.6788 0 Td
(2009;)Tj
2.8913 0 Td
(104:)Tj
-39.983 -1.1906 Td
(20802088)Tj
0.83 0.64 0.02 0 k
5.1308 0 Td
(https://)Tj
2.9551 0 Td
(doi.org/10.10)Tj
5.7332 0 Td
(38/ajg.2)Tj
3.4866 0 Td
(009.177)Tj
0 g
3.7701 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
2.9693 0 Td
(19436273)Tj
0 g
/F2 1 Tf
-26.667 -1.6228 Td
(22.)Tj
/F0 1 Tf
2.6219 0 Td
(Nahon)Tj
3.1111 0 Td
(S,)Tj
1.1551 0 Td
(Lahmek)Tj
3.7205 0 Td
(P,)Tj
1.1551 0 Td
(Lesgourgues)Tj
5.8962 0 Td
(B,)Tj
1.1551 0 Td
(Poupardin)Tj
4.6914 0 Td
(C,)Tj
1.2118 0 Td
(Chauss)Tj
3.3307 0 Td
(ade)Tj
1.8567 0 Td
(S,)Tj
1.1552 0 Td
(Peyrin-Bir)Tj
4.3086 0 Td
(oulet)Tj
2.3457 0 Td
(L)Tj
0.7654 0 Td
(et)Tj
1.0417 0 Td
(al.)Tj
1.2544 0 Td
(Diagnostic)Tj
-38.1547 -1.1906 Td
(delay)Tj
2.5654 0 Td
(in)Tj
0.978 0 Td
(a)Tj
0.7653 0 Td
(French)Tj
3.2812 0 Td
(cohort)Tj
2.9551 0 Td
(of)Tj
1.0417 0 Td
(Crohn's)Tj
3.6001 0 Td
(disease)Tj
3.6 0 Td
(patients.)Tj
3.9331 0 Td
(J)Tj
0.7158 0 Td
(Crohns)Tj
3.3874 0 Td
(Colitis,)Tj
3.1606 0 Td
(2014;)Tj
2.8985 0 Td
(8:)Tj
1.0346 0 Td
(964969)Tj
0.83 0.64 0.02 0 k
4.0394 0 Td
(https://doi.or)Tj
5.4143 0 Td
(g/)Tj
-43.3705 -1.1835 Td
(10.1016/)Tj
3.8198 0 Td
(j.crohns.20)Tj
4.8047 0 Td
(14.01.023)Tj
0 g
4.5922 0 Td
(PMID:)Tj
0.83 0.64 0.02 0 k
2.9693 0 Td
(245296)Tj
3.267 0 Td
(04)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 417.3165 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Disease)Tj
3.7701 0 Td
(outcome)Tj
3.9968 0 Td
(in)Tj
0.978 0 Td
(IBD)Tj
1.8638 0 Td
(in)Tj
0.978 0 Td
(a)Tj
0.7653 0 Td
(Hungarian)Tj
4.7481 0 Td
(center)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.02008)Tj
4.089 0 Td
(24)Tj
0 g
2.0906 0 Td
(July)Tj
1.9701 0 Td
(30,)Tj
1.5874 0 Td
(2018)Tj
35.894 0 Td
(8)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
254 0 obj
<>stream
endstream
endobj
255 0 obj
<>stream
endstream
endobj
256 0 obj
<>stream
endstream
endobj
257 0 obj
<>stream
endstream
endobj
258 0 obj
<>stream
endstream
endobj
259 0 obj
<>stream
endstream
endobj
260 0 obj
<>stream
endstream
endobj
261 0 obj
<>stream
endstream
endobj
262 0 obj
<>stream
endstream
endobj
263 0 obj
<>stream
endstream
endobj
264 0 obj
<>stream
endstream
endobj
265 0 obj
<>stream
endstream
endobj
266 0 obj
<>stream
endstream
endobj
267 0 obj
<>stream
endstream
endobj
268 0 obj
<>stream
endstream
endobj
269 0 obj
<>stream
BT
66.9477 0 Td
(8)Tj
ET
Q
endstream
endobj
10 0 obj
<>
endobj
270 0 obj
<>
endobj
271 0 obj
<>stream
%!PS-AdobeFont-1.0
%%This font is a conversion from MinionPro-Bold with the following copyright notice:
%\050c\051 2000, 2002 Adobe Systems Incorporated. All Rights Reserved. U.S. Patent Des. 337,604. Other patents pending.
11 dict begin
/FontName /MinionPro-Bold def
/FontType 1 def
/FontBBox {-125 -239 1052 750} readonly def
/FontMatrix [0.001 0 0 0.001 0 0] readonly def
/PaintType 0 def
/FontInfo 8 dict dup begin
/FullName (MinionPro-Bold) readonly def
/BaseFontName (MinionPro-Bold) def
/Notice (\\050c\\051 2000, 2002 Adobe Systems Incorporated. All Rights Reserved. U.S. Patent Des. 337,604. Other patents pending.) readonly def
end def
/Encoding 256 array
0 1 255 {1 index exch /.notdef put} for
dup 32 /space put
dup 33 /exclam put
dup 34 /quotedbl put
dup 35 /numbersign put
dup 36 /dollar put
dup 37 /percent put
dup 38 /ampersand put
dup 39 /quoteright put
dup 40 /parenleft put
dup 41 /parenright put
dup 42 /asterisk put
dup 43 /plus put
dup 44 /comma put
dup 45 /hyphen put
dup 46 /period put
dup 47 /slash put
dup 48 /zero put
dup 49 /one put
dup 50 /two put
dup 51 /three put
dup 52 /four put
dup 53 /five put
dup 54 /six put
dup 55 /seven put
dup 56 /eight put
dup 57 /nine put
dup 58 /colon put
dup 59 /semicolon put
dup 60 /less put
dup 61 /equal put
dup 62 /greater put
dup 63 /question put
dup 64 /at put
dup 65 /A put
dup 66 /B put
dup 67 /C put
dup 68 /D put
dup 69 /E put
dup 70 /F put
dup 71 /G put
dup 72 /H put
dup 73 /I put
dup 74 /J put
dup 75 /K put
dup 76 /L put
dup 77 /M put
dup 78 /N put
dup 79 /O put
dup 80 /P put
dup 81 /Q put
dup 82 /R put
dup 83 /S put
dup 84 /T put
dup 85 /U put
dup 86 /V put
dup 87 /W put
dup 88 /X put
dup 89 /Y put
dup 90 /Z put
dup 91 /bracketleft put
dup 92 /backslash put
dup 93 /bracketright put
dup 94 /asciicircum put
dup 95 /underscore put
dup 96 /quoteleft put
dup 97 /a put
dup 98 /b put
dup 99 /c put
dup 100 /d put
dup 101 /e put
dup 102 /f put
dup 103 /g put
dup 104 /h put
dup 105 /i put
dup 106 /j put
dup 107 /k put
dup 108 /l put
dup 109 /m put
dup 110 /n put
dup 111 /o put
dup 112 /p put
dup 113 /q put
dup 114 /r put
dup 115 /s put
dup 116 /t put
dup 117 /u put
dup 118 /v put
dup 119 /w put
dup 120 /x put
dup 121 /y put
dup 122 /z put
dup 123 /braceleft put
dup 124 /bar put
dup 125 /braceright put
dup 126 /asciitilde put
dup 127 /Euro put
dup 132 /Eth put
dup 133 /eth put
dup 134 /Thorn put
dup 135 /thorn put
dup 136 /onequarter put
dup 137 /onehalf put
dup 139 /plusminus put
dup 161 /exclamdown put
dup 162 /cent put
dup 163 /sterling put
dup 164 /fraction put
dup 165 /yen put
dup 166 /florin put
dup 167 /section put
dup 168 /currency put
dup 169 /quotesingle put
dup 170 /quotedblleft put
dup 171 /guillemotleft put
dup 172 /guilsinglleft put
dup 173 /guilsinglright put
dup 177 /endash put
dup 178 /dagger put
dup 179 /daggerdbl put
dup 180 /periodcentered put
dup 182 /paragraph put
dup 183 /bullet put
dup 184 /quotesinglbase put
dup 185 /quotedblbase put
dup 186 /quotedblright put
dup 187 /guillemotright put
dup 188 /ellipsis put
dup 189 /perthousand put
dup 191 /questiondown put
dup 193 /grave put
dup 194 /acute put
dup 195 /circumflex put
dup 196 /tilde put
dup 197 /macron put
dup 198 /breve put
dup 199 /dotaccent put
dup 200 /dieresis put
dup 202 /ring put
dup 203 /cedilla put
dup 205 /hungarumlaut put
dup 206 /ogonek put
dup 207 /caron put
dup 208 /emdash put
dup 225 /AE put
dup 227 /ordfeminine put
dup 232 /Lslash put
dup 233 /Oslash put
dup 234 /OE put
dup 235 /ordmasculine put
dup 241 /ae put
dup 245 /dotlessi put
dup 248 /lslash put
dup 249 /oslash put
dup 250 /oe put
dup 251 /germandbls put
readonly def
currentdict end
currentfile eexec
M#1H5 J6o\&rtS(#v\0\V7Fe༙OYx5-cY9^%Y6
(efIOldN"wȰ;)UƽoFg/rvV$JS8_oc@
o9-eGJp}[Do]mN=4*{ܯq=eU^t6¤)quu͟:LW=1UB̵X>
Dɮ"\ :띥W 5'xUz{:Vé 'zlA" InJn]7e
AuAͼs]j
;l/> 8TRE#AC*+up\`$o_6;]]=6'ʙ0JEE .J